Gene name: MRE11
Reference locus (S288C): YMR224C
Gene biotype: protein_coding
Description: Double-strand break repair protein MRE11; Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress; Belongs to the MRE11/RAD32 family
Top 10 interactors (score): XRS2 (0.999); RAD50 (0.999); TEL1 (0.999); RAD9 (0.998); YKU80 (0.998); YKU70 (0.997); SPO11 (0.996); EXO1 (0.996); SGS1 (0.995); MEC1 (0.992); RAD51 (0.984); SAE2 (0.983); DNA2 (0.98); RAD27 (0.97); DNL4 (0.967); RAD52 (0.95); RTT107 (0.945); PSO2 (0.941); RAD53 (0.931); SRS2 (0.919)
Homologues (species, bitscore): MRE11A (Homo sapiens, 402.1); Mre11a (Mus musculus, 407.1); mre11a (Xenopus tropicalis, 409.5); Mre11 (Drosophila melanogaster, 318.5); mre-11 (Caenorhabditis elegans, 282.3); MRE11 (Arabidopsis thaliana, 339.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:758481-760559:- | gene-YMR224C_AKU4011 | rna-NM_001182731.1_AKU4011 | cds-NP_013951.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:194049-196127:+ | gene-YMR224C_BG1 | rna-NM_001182731.1_BG1 | cds-NP_013951.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:702708-704786:- | gene-YMR224C_Bruggeman | rna-NM_001182731.1_Bruggeman | cds-NP_013951.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:706583-708661:- | gene-YMR224C_CAT1 | rna-NM_001182731.1_CAT1 | cds-NP_013951.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:690741-692819:- | gene-YMR224C_CBS1585 | rna-NM_001182731.1_CBS1585 | cds-NP_013951.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:695010-697088:- | gene-YMR224C_CBS436 | rna-NM_001182731.1_CBS436 | cds-NP_013951.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:802303-804381:- | gene-YMR224C_CBS6412 | rna-NM_001182731.1_CBS6412 | cds-NP_013951.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:689893-691971:- | gene-YMR224C_CBS6413 | rna-NM_001182731.1_CBS6413 | cds-NP_013951.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:713318-715396:- | gene-YMR224C_CENPK1137D | rna-NM_001182731.1_CENPK1137D | cds-NP_013951.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:750947-753025:- | gene-YMR224C_EthanolRed | rna-NM_001182731.1_EthanolRed | cds-NP_013951.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:696599-698677:- | gene-YMR224C_FaliES1 | rna-NM_001182731.1_FaliES1 | cds-NP_013951.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:87358-89436:+ | gene-YMR224C_JAY291 | rna-NM_001182731.1_JAY291 | cds-NP_013951.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:696491-698569:- | gene-YMR224C_MUCL30387 | rna-NM_001182731.1_MUCL30387 | cds-NP_013951.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:703719-705797:- | gene-YMR224C_MUCL30388 | rna-NM_001182731.1_MUCL30388 | cds-NP_013951.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:691811-693889:- | gene-YMR224C_MUCL39482 | rna-NM_001182731.1_MUCL39482 | cds-NP_013951.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:699155-701233:- | gene-YMR224C_MUCL42920 | rna-NM_001182731.1_MUCL42920 | cds-NP_013951.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:718529-720607:- | gene-YMR224C_NCIM3186 | rna-NM_001182731.1_NCIM3186 | cds-NP_013951.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:691468-693546:- | gene-YMR224C_NCYC1407 | rna-NM_001182731.1_NCYC1407 | cds-NP_013951.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:701330-703408:- | gene-YMR224C_PE2H3 | rna-NM_001182731.1_PE2H3 | cds-NP_013951.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:702346-704424:- | gene-YMR224C_PE2H4 | rna-NM_001182731.1_PE2H4 | cds-NP_013951.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:718575-720653:- | gene-YMR224C_S288C | rna-NM_001182731.1_S288C | cds-NP_013951.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:87473-89551:+ | gene-YMR224C_SA1 | rna-NM_001182731.1_SA1 | cds-NP_013951.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:692770-694848:- | gene-YMR224C_ThermosaccDry | rna-NM_001182731.1_ThermosaccDry | cds-NP_013951.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:705853-707931:- | gene-YMR224C_VR1 | rna-NM_001182731.1_VR1 | cds-NP_013951.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:108475-110553:- | gene-YMR224C_ZTW1 | rna-NM_001182731.1_ZTW1 | cds-NP_013951.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:710698-712776:- | gene-YMR224C_Sparadoxus | rna-NM_001182731.1_Sparadoxus | cds-NP_013951.1_Sparadoxus | 89.0 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |