Gene name: MRC1
Reference locus (S288C): YCL061C
Gene biotype: protein_coding
Description: S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; mammalian claspin homolog
Top 10 interactors (score): MCM4 (0.999); TOF1 (0.999); CSM3 (0.999); MEC1 (0.999); RAD53 (0.999); CDC45 (0.999); CTF4 (0.999); DUN1 (0.998); MCM2 (0.998); CDC7 (0.997); RAD9 (0.995); MCM10 (0.988); POL2 (0.987); MCM6 (0.985); SLD5 (0.984); MCM3 (0.984); SRS2 (0.984); MCM5 (0.977); DIA2 (0.977); HTA1 (0.973)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:20112-23399:- | gene-YCL061C_AKU4011 | rna-NM_001178704.1_AKU4011 | cds-NP_009871.2_AKU4011 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000090.1:5032-8313:- | gene-YCL061C_BG1 | rna-NM_001178704.1_BG1 | cds-NP_009871.2_BG1 | 98.8 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:7045-10812:- | gene-YCL061C_Bruggeman | rna-NM_001178704.1_Bruggeman | cds-NP_009871.2_Bruggeman | 86.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:19997-23284:- | gene-YCL061C_CAT1 | rna-NM_001178704.1_CAT1 | cds-NP_009871.2_CAT1 | 99.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:20795-24082:- | gene-YCL061C_CBS1585 | rna-NM_001178704.1_CBS1585 | cds-NP_009871.2_CBS1585 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:19338-22628:- | gene-YCL061C_CBS436 | rna-NM_001178704.1_CBS436 | cds-NP_009871.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:8553-11840:- | gene-YCL061C_CBS6412 | rna-NM_001178704.1_CBS6412 | cds-NP_009871.2_CBS6412 | 98.9 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:19567-22854:- | gene-YCL061C_CBS6413 | rna-NM_001178704.1_CBS6413 | cds-NP_009871.2_CBS6413 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:18409-21699:- | gene-YCL061C_CENPK1137D | rna-NM_001178704.1_CENPK1137D | cds-NP_009871.2_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:18341-21628:- | gene-YCL061C_EthanolRed | rna-NM_001178704.1_EthanolRed | cds-NP_009871.2_EthanolRed | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:19103-22390:- | gene-YCL061C_FaliES1 | rna-NM_001178704.1_FaliES1 | cds-NP_009871.2_FaliES1 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000225.1:61941-65228:+ | gene-YCL061C_JAY291 | rna-NM_001178704.1_JAY291 | cds-NP_009871.2_JAY291 | 99.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:6523-9813:- | gene-YCL061C_MUCL30387 | rna-NM_001178704.1_MUCL30387 | cds-NP_009871.2_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:6822-10109:- | gene-YCL061C_MUCL30388 | rna-NM_001178704.1_MUCL30388 | cds-NP_009871.2_MUCL30388 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:21181-24468:- | gene-YCL061C_MUCL39482 | rna-NM_001178704.1_MUCL39482 | cds-NP_009871.2_MUCL39482 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:7099-10389:- | gene-YCL061C_MUCL42920 | rna-NM_001178704.1_MUCL42920 | cds-NP_009871.2_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:18448-21738:- | gene-YCL061C_NCIM3186 | rna-NM_001178704.1_NCIM3186 | cds-NP_009871.2_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:21507-24794:- | gene-YCL061C_NCYC1407 | rna-NM_001178704.1_NCYC1407 | cds-NP_009871.2_NCYC1407 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:19278-22565:- | gene-YCL061C_PE2H3 | rna-NM_001178704.1_PE2H3 | cds-NP_009871.2_PE2H3 | 99.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:19235-22522:- | gene-YCL061C_PE2H4 | rna-NM_001178704.1_PE2H4 | cds-NP_009871.2_PE2H4 | 99.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:18816-22106:- | gene-YCL061C_S288C | rna-NM_001178704.1_S288C | cds-NP_009871.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000061.1:5970-9257:- | gene-YCL061C_SA1 | rna-NM_001178704.1_SA1 | cds-NP_009871.2_SA1 | 99.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:19422-22709:- | gene-YCL061C_ThermosaccDry | rna-NM_001178704.1_ThermosaccDry | cds-NP_009871.2_ThermosaccDry | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:24710-28000:- | gene-YCL061C_VR1 | rna-NM_001178704.1_VR1 | cds-NP_009871.2_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:19650-22937:- | gene-YCL061C_ZTW1 | rna-NM_001178704.1_ZTW1 | cds-NP_009871.2_ZTW1 | 98.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:49368-52658:- | gene-YCL061C_Sparadoxus | rna-NM_001178704.1_Sparadoxus | cds-NP_009871.2_Sparadoxus | 84.2 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |