Gene name: MPS1
Reference locus (S288C): YDL028C
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase MPS1; Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); similar to human Mps1p
Top 10 interactors (score): MAD1 (0.999); MAD2 (0.999); BUB1 (0.999); MAD3 (0.998); NDC80 (0.993); NUF2 (0.991); BUB3 (0.991); SPC105 (0.99); CIN8 (0.985); ESP1 (0.983); CDC20 (0.975); SPC97 (0.971); ASE1 (0.971); BUB2 (0.967); CKS1 (0.966); IPL1 (0.958); KIP1 (0.957); KIP2 (0.954); CDC5 (0.953); CDH1 (0.953)
Homologues (species, bitscore): TTK (Homo sapiens, 212.6); Ttk (Mus musculus, 213.8); ttk (Danio rerio, 213.0); ttk (Xenopus tropicalis, 183.0); ald (Drosophila melanogaster, 162.2); let-502 (Caenorhabditis elegans, 103.2); PPK1 (Arabidopsis thaliana, 231.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:387073-389367:- | gene-YDL028C_AKU4011 | rna-NM_001180087.2_AKU4011 | cds-NP_010256.2_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:160502-162796:+ | gene-YDL028C_BG1 | rna-NM_001180087.2_BG1 | cds-NP_010256.2_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:405739-408033:- | gene-YDL028C_Bruggeman | rna-NM_001180087.2_Bruggeman | cds-NP_010256.2_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:400281-402575:- | gene-YDL028C_CAT1 | rna-NM_001180087.2_CAT1 | cds-NP_010256.2_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:383488-385782:- | gene-YDL028C_CBS1585 | rna-NM_001180087.2_CBS1585 | cds-NP_010256.2_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:401020-403314:- | gene-YDL028C_CBS436 | rna-NM_001180087.2_CBS436 | cds-NP_010256.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:381283-383577:- | gene-YDL028C_CBS6412 | rna-NM_001180087.2_CBS6412 | cds-NP_010256.2_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:403250-405544:- | gene-YDL028C_CBS6413 | rna-NM_001180087.2_CBS6413 | cds-NP_010256.2_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:399856-402150:- | gene-YDL028C_CENPK1137D | rna-NM_001180087.2_CENPK1137D | cds-NP_010256.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:395903-398197:- | gene-YDL028C_EthanolRed | rna-NM_001180087.2_EthanolRed | cds-NP_010256.2_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:402095-404389:- | gene-YDL028C_FaliES1 | rna-NM_001180087.2_FaliES1 | cds-NP_010256.2_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000370.1:16639-18933:- | gene-YDL028C_JAY291 | rna-NM_001180087.2_JAY291 | cds-NP_010256.2_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:401470-403764:- | gene-YDL028C_MUCL30387 | rna-NM_001180087.2_MUCL30387 | cds-NP_010256.2_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:391984-394278:- | gene-YDL028C_MUCL30388 | rna-NM_001180087.2_MUCL30388 | cds-NP_010256.2_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:384666-386960:- | gene-YDL028C_MUCL39482 | rna-NM_001180087.2_MUCL39482 | cds-NP_010256.2_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:307030-309324:- | gene-YDL028C_MUCL42920 | rna-NM_001180087.2_MUCL42920 | cds-NP_010256.2_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:400920-403214:- | gene-YDL028C_NCIM3186 | rna-NM_001180087.2_NCIM3186 | cds-NP_010256.2_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:384581-386875:- | gene-YDL028C_NCYC1407 | rna-NM_001180087.2_NCYC1407 | cds-NP_010256.2_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:392120-394414:- | gene-YDL028C_PE2H3 | rna-NM_001180087.2_PE2H3 | cds-NP_010256.2_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:391478-393772:- | gene-YDL028C_PE2H4 | rna-NM_001180087.2_PE2H4 | cds-NP_010256.2_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:400997-403291:- | gene-YDL028C_S288C | rna-NM_001180087.2_S288C | cds-NP_010256.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:31647-33941:+ | gene-YDL028C_SA1 | rna-NM_001180087.2_SA1 | cds-NP_010256.2_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:401553-403847:- | gene-YDL028C_ThermosaccDry | rna-NM_001180087.2_ThermosaccDry | cds-NP_010256.2_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:404614-406908:- | gene-YDL028C_VR1 | rna-NM_001180087.2_VR1 | cds-NP_010256.2_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:399455-401749:- | gene-YDL028C_ZTW1 | rna-NM_001180087.2_ZTW1 | cds-NP_010256.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:403686-405980:- | gene-YDL028C_Sparadoxus | rna-NM_001180087.2_Sparadoxus | cds-NP_010256.2_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |