Gene name: MPH1
Reference locus (S288C): YIR002C
Gene biotype: protein_coding
Description: 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer
Top 10 interactors (score): SGS1 (0.999); RFA1 (0.998); SRS2 (0.996); RMI1 (0.995); MUS81 (0.995); RAD51 (0.993); TOP3 (0.991); SMC5 (0.987); RAD52 (0.983); SMC6 (0.982); RAD10 (0.981); RAD5 (0.981); RFA2 (0.98); REV3 (0.974); MSH6 (0.965); RAD1 (0.952); MMS4 (0.947); RAD54 (0.938); MMS21 (0.932); PIF1 (0.928)
Homologues (species, bitscore): FANCM (Homo sapiens, 345.9); Fancm (Mus musculus, 343.2); Fancm (Danio rerio, 119.4); fancm (Xenopus tropicalis, 249.6); CG7922 (Drosophila melanogaster, 298.1); R05D11.4 (Caenorhabditis elegans, 62.4); FANCM (Arabidopsis thaliana, 310.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:356810-359791:- | gene-YIR002C_AKU4011 | rna-NM_001179524.1_AKU4011 | cds-NP_012267.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000072.1:66817-69798:+ | gene-YIR002C_BG1 | rna-NM_001179524.1_BG1 | cds-NP_012267.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:361276-364227:- | gene-YIR002C_Bruggeman | rna-NM_001179524.1_Bruggeman | cds-NP_012267.1_Bruggeman | 98.9 | 98.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:347910-350891:- | gene-YIR002C_CAT1 | rna-NM_001179524.1_CAT1 | cds-NP_012267.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:356827-359808:- | gene-YIR002C_CBS1585 | rna-NM_001179524.1_CBS1585 | cds-NP_012267.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:349562-352543:- | gene-YIR002C_CBS436 | rna-NM_001179524.1_CBS436 | cds-NP_012267.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:352330-355311:- | gene-YIR002C_CBS6412 | rna-NM_001179524.1_CBS6412 | cds-NP_012267.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:348907-351888:- | gene-YIR002C_CBS6413 | rna-NM_001179524.1_CBS6413 | cds-NP_012267.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:349476-352457:- | gene-YIR002C_CENPK1137D | rna-NM_001179524.1_CENPK1137D | cds-NP_012267.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:339871-342852:- | gene-YIR002C_EthanolRed | rna-NM_001179524.1_EthanolRed | cds-NP_012267.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:358115-361096:- | gene-YIR002C_FaliES1 | rna-NM_001179524.1_FaliES1 | cds-NP_012267.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000009.1:30399-33380:+ | gene-YIR002C_JAY291 | rna-NM_001179524.1_JAY291 | cds-NP_012267.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:358451-361432:- | gene-YIR002C_MUCL30387 | rna-NM_001179524.1_MUCL30387 | cds-NP_012267.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:355189-358169:- | gene-YIR002C_MUCL30388 | rna-NM_001179524.1_MUCL30388 | cds-NP_012267.1_MUCL30388 | 95.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:357464-360445:- | gene-YIR002C_MUCL39482 | rna-NM_001179524.1_MUCL39482 | cds-NP_012267.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:361085-364036:- | gene-YIR002C_MUCL42920 | rna-NM_001179524.1_MUCL42920 | cds-NP_012267.1_MUCL42920 | 98.9 | 98.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:357415-360396:- | gene-YIR002C_NCIM3186 | rna-NM_001179524.1_NCIM3186 | cds-NP_012267.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:361709-364690:- | gene-YIR002C_NCYC1407 | rna-NM_001179524.1_NCYC1407 | cds-NP_012267.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:351488-354469:- | gene-YIR002C_PE2H3 | rna-NM_001179524.1_PE2H3 | cds-NP_012267.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:346194-349175:- | gene-YIR002C_PE2H4 | rna-NM_001179524.1_PE2H4 | cds-NP_012267.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:357415-360396:- | gene-YIR002C_S288C | rna-NM_001179524.1_S288C | cds-NP_012267.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000066.1:32249-35230:- | gene-YIR002C_SA1 | rna-NM_001179524.1_SA1 | cds-NP_012267.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:356220-359201:- | gene-YIR002C_ThermosaccDry | rna-NM_001179524.1_ThermosaccDry | cds-NP_012267.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:352049-355030:- | gene-YIR002C_VR1 | rna-NM_001179524.1_VR1 | cds-NP_012267.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:330224-333205:- | gene-YIR002C_ZTW1 | rna-NM_001179524.1_ZTW1 | cds-NP_012267.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:351543-354521:- | gene-YIR002C_Sparadoxus | rna-NM_001179524.1_Sparadoxus | cds-NP_012267.1_Sparadoxus | 89.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |