Gene name: MPC3
Reference locus (S288C): YGR243W
Gene biotype: protein_coding
Description: Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): MPC1 (0.998); CRC1 (0.975); TMA10 (0.954); RIP1 (0.932); COX6 (0.847); ATP4 (0.78); QCR2 (0.774); QCR7 (0.727); ATO2 (0.712); YAT2 (0.711); ISF1 (0.696); YIA6 (0.693); ATP5 (0.671); YMR206W (0.671); JEN1 (0.658); ALD4 (0.65); RGI1 (0.638); ACH1 (0.626); YGR210C (0.619); YMC1 (0.615)
Homologues (species, bitscore): MPC2 (Homo sapiens, 99.8); Mpc2 (Mus musculus, 99.0); mpc2 (Danio rerio, 104.0); mpc2 (Xenopus tropicalis, 106.3); CG9396 (Drosophila melanogaster, 95.5); F53F10.3 (Caenorhabditis elegans, 111.3); AT4G22310 (Arabidopsis thaliana, 90.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:942750-943190:+ | gene-YGR243W_AKU4011 | rna-NM_001181372.1_AKU4011 | cds-NP_011759.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:222844-223284:+ | gene-YGR243W_BG1 | rna-NM_001181372.1_BG1 | cds-NP_011759.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:950340-950780:+ | gene-YGR243W_Bruggeman | rna-NM_001181372.1_Bruggeman | cds-NP_011759.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:949859-950299:+ | gene-YGR243W_CAT1 | rna-NM_001181372.1_CAT1 | cds-NP_011759.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:945607-946047:+ | gene-YGR243W_CBS1585 | rna-NM_001181372.1_CBS1585 | cds-NP_011759.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:949258-949698:+ | gene-YGR243W_CBS436 | rna-NM_001181372.1_CBS436 | cds-NP_011759.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:936490-936930:+ | gene-YGR243W_CBS6412 | rna-NM_001181372.1_CBS6412 | cds-NP_011759.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:942541-942981:+ | gene-YGR243W_CBS6413 | rna-NM_001181372.1_CBS6413 | cds-NP_011759.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:977017-977457:+ | gene-YGR243W_CENPK1137D | rna-NM_001181372.1_CENPK1137D | cds-NP_011759.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:930582-931022:+ | gene-YGR243W_EthanolRed | rna-NM_001181372.1_EthanolRed | cds-NP_011759.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:935388-935828:+ | gene-YGR243W_FaliES1 | rna-NM_001181372.1_FaliES1 | cds-NP_011759.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000076.1:94465-94905:- | gene-YGR243W_JAY291 | rna-NM_001181372.1_JAY291 | cds-NP_011759.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:948256-948696:+ | gene-YGR243W_MUCL30387 | rna-NM_001181372.1_MUCL30387 | cds-NP_011759.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:947516-947956:+ | gene-YGR243W_MUCL30388 | rna-NM_001181372.1_MUCL30388 | cds-NP_011759.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:940733-941173:+ | gene-YGR243W_MUCL39482 | rna-NM_001181372.1_MUCL39482 | cds-NP_011759.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:959236-959676:+ | gene-YGR243W_MUCL42920 | rna-NM_001181372.1_MUCL42920 | cds-NP_011759.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:977336-977776:+ | gene-YGR243W_NCIM3186 | rna-NM_001181372.1_NCIM3186 | cds-NP_011759.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:936352-936792:+ | gene-YGR243W_NCYC1407 | rna-NM_001181372.1_NCYC1407 | cds-NP_011759.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:961528-961968:+ | gene-YGR243W_PE2H3 | rna-NM_001181372.1_PE2H3 | cds-NP_011759.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:966367-966807:+ | gene-YGR243W_PE2H4 | rna-NM_001181372.1_PE2H4 | cds-NP_011759.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:977336-977776:+ | gene-YGR243W_S288C | rna-NM_001181372.1_S288C | cds-NP_011759.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000045.1:23718-24158:- | gene-YGR243W_SA1 | rna-NM_001181372.1_SA1 | cds-NP_011759.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:955915-956355:+ | gene-YGR243W_ThermosaccDry | rna-NM_001181372.1_ThermosaccDry | cds-NP_011759.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:1061174-1061614:+ | gene-YGR243W_VR1 | rna-NM_001181372.1_VR1 | cds-NP_011759.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:257323-257763:+ | gene-YGR243W_ZTW1 | rna-NM_001181372.1_ZTW1 | cds-NP_011759.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:948146-948586:+ | gene-YGR243W_Sparadoxus | rna-NM_001181372.1_Sparadoxus | cds-NP_011759.1_Sparadoxus | 86.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |