Gene name: MPC1
Reference locus (S288C): YGL080W
Gene biotype: protein_coding
Description: Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia
Top 10 interactors (score): MPC3 (0.998); MPC2 (0.996); CYT1 (0.98); COX4 (0.966); ACP1 (0.964); ATP16 (0.963); COX6 (0.962); MAE1 (0.861); ATP4 (0.832); CRC1 (0.77); TRM112 (0.741); MTC3 (0.689); COX5B (0.689); COX5A (0.689); COX13 (0.684); COX19 (0.623); YOP1 (0.588); DIC1 (0.574); ACS2 (0.526); RIP1 (0.526)
Homologues (species, bitscore): MPC1 (Homo sapiens, 116.7); Mpc1 (Mus musculus, 117.5); mpc1 (Danio rerio, 122.1); mpc1 (Xenopus tropicalis, 116.3); Mpc1 (Drosophila melanogaster, 117.1); R07E5.13 (Caenorhabditis elegans, 114.8); AT5G20090 (Arabidopsis thaliana, 92.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:361643-362035:+ | gene-YGL080W_AKU4011 | rna-NM_001180945.1_AKU4011 | cds-NP_011435.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:43370-43762:- | gene-YGL080W_BG1 | rna-NM_001180945.1_BG1 | cds-NP_011435.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:364125-364517:+ | gene-YGL080W_Bruggeman | rna-NM_001180945.1_Bruggeman | cds-NP_011435.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:361040-361432:+ | gene-YGL080W_CAT1 | rna-NM_001180945.1_CAT1 | cds-NP_011435.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:364968-365360:+ | gene-YGL080W_CBS1585 | rna-NM_001180945.1_CBS1585 | cds-NP_011435.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:359252-359644:+ | gene-YGL080W_CBS436 | rna-NM_001180945.1_CBS436 | cds-NP_011435.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:349348-349740:+ | gene-YGL080W_CBS6412 | rna-NM_001180945.1_CBS6412 | cds-NP_011435.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:359272-359664:+ | gene-YGL080W_CBS6413 | rna-NM_001180945.1_CBS6413 | cds-NP_011435.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:358825-359217:+ | gene-YGL080W_CENPK1137D | rna-NM_001180945.1_CENPK1137D | cds-NP_011435.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:350716-351108:+ | gene-YGL080W_EthanolRed | rna-NM_001180945.1_EthanolRed | cds-NP_011435.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:353277-353669:+ | gene-YGL080W_FaliES1 | rna-NM_001180945.1_FaliES1 | cds-NP_011435.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000369.1:38909-39301:+ | gene-YGL080W_JAY291 | rna-NM_001180945.1_JAY291 | cds-NP_011435.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:361102-361494:+ | gene-YGL080W_MUCL30387 | rna-NM_001180945.1_MUCL30387 | cds-NP_011435.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:364087-364479:+ | gene-YGL080W_MUCL30388 | rna-NM_001180945.1_MUCL30388 | cds-NP_011435.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:361496-361888:+ | gene-YGL080W_MUCL39482 | rna-NM_001180945.1_MUCL39482 | cds-NP_011435.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:366385-366777:+ | gene-YGL080W_MUCL42920 | rna-NM_001180945.1_MUCL42920 | cds-NP_011435.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:358636-359028:+ | gene-YGL080W_NCIM3186 | rna-NM_001180945.1_NCIM3186 | cds-NP_011435.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:353031-353423:+ | gene-YGL080W_NCYC1407 | rna-NM_001180945.1_NCYC1407 | cds-NP_011435.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:354677-355069:+ | gene-YGL080W_PE2H3 | rna-NM_001180945.1_PE2H3 | cds-NP_011435.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:359660-360052:+ | gene-YGL080W_PE2H4 | rna-NM_001180945.1_PE2H4 | cds-NP_011435.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:358636-359028:+ | gene-YGL080W_S288C | rna-NM_001180945.1_S288C | cds-NP_011435.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000089.1:36037-36429:+ | gene-YGL080W_SA1 | rna-NM_001180945.1_SA1 | cds-NP_011435.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:353530-353922:+ | gene-YGL080W_ThermosaccDry | rna-NM_001180945.1_ThermosaccDry | cds-NP_011435.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:463404-463796:+ | gene-YGL080W_VR1 | rna-NM_001180945.1_VR1 | cds-NP_011435.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:350893-351285:+ | gene-YGL080W_ZTW1 | rna-NM_001180945.1_ZTW1 | cds-NP_011435.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:356511-356903:+ | gene-YGL080W_Sparadoxus | rna-NM_001180945.1_Sparadoxus | cds-NP_011435.1_Sparadoxus | 91.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |