Gene name: MOT2
Reference locus (S288C): YER068W
Gene biotype: protein_coding
Description: General negative regulator of transcription subunit 4; Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication
Top 10 interactors (score): CDC39 (0.999); CCR4 (0.999); RRP6 (0.999); UBC4 (0.999); CAF40 (0.999); NOT3 (0.999); POP2 (0.999); CDC36 (0.999); NOT5 (0.999); CAF130 (0.997); UBC5 (0.979); DHH1 (0.975); MTR4 (0.974); RKR1 (0.965); CAF16 (0.921); JHD2 (0.92); RRP42 (0.918); SKI6 (0.918); SPT6 (0.896); SMY2 (0.89)
Homologues (species, bitscore): CNOT4 (Homo sapiens, 228.4); Cnot4 (Mus musculus, 228.4); zgc:63566 (Danio rerio, 228.4); cnot4 (Xenopus tropicalis, 226.5); Cnot4 (Drosophila melanogaster, 213.4); ntl-4 (Caenorhabditis elegans, 189.1); AT5G60170 (Arabidopsis thaliana, 205.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:286828-288591:+ | gene-YER068W_AKU4011 | rna-NM_001178959.3_AKU4011 | cds-NP_010991.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:137188-138951:- | gene-YER068W_BG1 | rna-NM_001178959.3_BG1 | cds-NP_010991.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:296426-298189:+ | gene-YER068W_Bruggeman | rna-NM_001178959.3_Bruggeman | cds-NP_010991.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:290278-292041:+ | gene-YER068W_CAT1 | rna-NM_001178959.3_CAT1 | cds-NP_010991.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:286679-288442:+ | gene-YER068W_CBS1585 | rna-NM_001178959.3_CBS1585 | cds-NP_010991.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:288835-290598:+ | gene-YER068W_CBS436 | rna-NM_001178959.3_CBS436 | cds-NP_010991.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:286150-287913:+ | gene-YER068W_CBS6412 | rna-NM_001178959.3_CBS6412 | cds-NP_010991.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:292160-293923:+ | gene-YER068W_CBS6413 | rna-NM_001178959.3_CBS6413 | cds-NP_010991.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:290877-292640:+ | gene-YER068W_CENPK1137D | rna-NM_001178959.3_CENPK1137D | cds-NP_010991.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:287165-288928:+ | gene-YER068W_EthanolRed | rna-NM_001178959.3_EthanolRed | cds-NP_010991.3_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:287617-289380:+ | gene-YER068W_FaliES1 | rna-NM_001178959.3_FaliES1 | cds-NP_010991.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000153.1:2681-4444:+ | gene-YER068W_JAY291 | rna-NM_001178959.3_JAY291 | cds-NP_010991.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:291824-293587:+ | gene-YER068W_MUCL30387 | rna-NM_001178959.3_MUCL30387 | cds-NP_010991.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:287494-289257:+ | gene-YER068W_MUCL30388 | rna-NM_001178959.3_MUCL30388 | cds-NP_010991.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:285715-287478:+ | gene-YER068W_MUCL39482 | rna-NM_001178959.3_MUCL39482 | cds-NP_010991.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:292956-294719:+ | gene-YER068W_MUCL42920 | rna-NM_001178959.3_MUCL42920 | cds-NP_010991.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:293049-294812:+ | gene-YER068W_NCIM3186 | rna-NM_001178959.3_NCIM3186 | cds-NP_010991.3_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:290782-292545:+ | gene-YER068W_NCYC1407 | rna-NM_001178959.3_NCYC1407 | cds-NP_010991.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:301432-303195:+ | gene-YER068W_PE2H3 | rna-NM_001178959.3_PE2H3 | cds-NP_010991.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:291373-293136:+ | gene-YER068W_PE2H4 | rna-NM_001178959.3_PE2H4 | cds-NP_010991.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:293050-294813:+ | gene-YER068W_S288C | rna-NM_001178959.3_S288C | cds-NP_010991.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:2692-4455:+ | gene-YER068W_SA1 | rna-NM_001178959.3_SA1 | cds-NP_010991.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:288413-290176:+ | gene-YER068W_ThermosaccDry | rna-NM_001178959.3_ThermosaccDry | cds-NP_010991.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:289111-290874:+ | gene-YER068W_VR1 | rna-NM_001178959.3_VR1 | cds-NP_010991.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:285582-287345:+ | gene-YER068W_ZTW1 | rna-NM_001178959.3_ZTW1 | cds-NP_010991.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:288965-290728:+ | gene-YER068W_Sparadoxus | rna-NM_001178959.3_Sparadoxus | cds-NP_010991.3_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |