Gene name: MON1
Reference locus (S288C): YGL124C
Gene biotype: protein_coding
Description: Vacuolar fusion protein MON1; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to the vacuolar membrane; required for autophagy, the CVT pathway and mitophagy; potential Cdc28 substrate; Belongs to the MON1/SAND family
Top 10 interactors (score): YPT7 (0.999); CCZ1 (0.999); VAM6 (0.99); PEP5 (0.986); GDI1 (0.977); VPS9 (0.964); VPS21 (0.957); PEP3 (0.952); VPS33 (0.946); VAM3 (0.945); VPS3 (0.94); VTI1 (0.936); VPS8 (0.927); SNX3 (0.926); MRS6 (0.925); VPS34 (0.905); YKT6 (0.902); MON2 (0.898); VPS41 (0.89); VPS16 (0.877)
Homologues (species, bitscore): MON1A (Homo sapiens, 169.1); Mon1a (Mus musculus, 168.3); mon1a (Danio rerio, 157.9); mon1a (Xenopus tropicalis, 160.2); Mon1 (Drosophila melanogaster, 160.6); sand-1 (Caenorhabditis elegans, 112.1); AT2G28390 (Arabidopsis thaliana, 116.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:277592-279526:- | gene-YGL124C_AKU4011 | rna-NM_001180989.2_AKU4011 | cds-NP_011391.2_AKU4011 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:125617-127551:+ | gene-YGL124C_BG1 | rna-NM_001180989.2_BG1 | cds-NP_011391.2_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:280297-282231:- | gene-YGL124C_Bruggeman | rna-NM_001180989.2_Bruggeman | cds-NP_011391.2_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:275876-277810:- | gene-YGL124C_CAT1 | rna-NM_001180989.2_CAT1 | cds-NP_011391.2_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:280917-282851:- | gene-YGL124C_CBS1585 | rna-NM_001180989.2_CBS1585 | cds-NP_011391.2_CBS1585 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:275829-277763:- | gene-YGL124C_CBS436 | rna-NM_001180989.2_CBS436 | cds-NP_011391.2_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:266196-268130:- | gene-YGL124C_CBS6412 | rna-NM_001180989.2_CBS6412 | cds-NP_011391.2_CBS6412 | 98.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:275795-277729:- | gene-YGL124C_CBS6413 | rna-NM_001180989.2_CBS6413 | cds-NP_011391.2_CBS6413 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:275039-276973:- | gene-YGL124C_CENPK1137D | rna-NM_001180989.2_CENPK1137D | cds-NP_011391.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:267116-269050:- | gene-YGL124C_EthanolRed | rna-NM_001180989.2_EthanolRed | cds-NP_011391.2_EthanolRed | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:269297-271231:- | gene-YGL124C_FaliES1 | rna-NM_001180989.2_FaliES1 | cds-NP_011391.2_FaliES1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000046.1:30402-32336:+ | gene-YGL124C_JAY291 | rna-NM_001180989.2_JAY291 | cds-NP_011391.2_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:277267-279201:- | gene-YGL124C_MUCL30387 | rna-NM_001180989.2_MUCL30387 | cds-NP_011391.2_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:280385-282319:- | gene-YGL124C_MUCL30388 | rna-NM_001180989.2_MUCL30388 | cds-NP_011391.2_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:278015-279949:- | gene-YGL124C_MUCL39482 | rna-NM_001180989.2_MUCL39482 | cds-NP_011391.2_MUCL39482 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:281259-283193:- | gene-YGL124C_MUCL42920 | rna-NM_001180989.2_MUCL42920 | cds-NP_011391.2_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:274780-276714:- | gene-YGL124C_NCIM3186 | rna-NM_001180989.2_NCIM3186 | cds-NP_011391.2_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:269504-271438:- | gene-YGL124C_NCYC1407 | rna-NM_001180989.2_NCYC1407 | cds-NP_011391.2_NCYC1407 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:270893-272827:- | gene-YGL124C_PE2H3 | rna-NM_001180989.2_PE2H3 | cds-NP_011391.2_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:275891-277825:- | gene-YGL124C_PE2H4 | rna-NM_001180989.2_PE2H4 | cds-NP_011391.2_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:274780-276714:- | gene-YGL124C_S288C | rna-NM_001180989.2_S288C | cds-NP_011391.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000064.1:19661-21595:- | gene-YGL124C_SA1 | rna-NM_001180989.2_SA1 | cds-NP_011391.2_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:269509-271443:- | gene-YGL124C_ThermosaccDry | rna-NM_001180989.2_ThermosaccDry | cds-NP_011391.2_ThermosaccDry | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:379620-381554:- | gene-YGL124C_VR1 | rna-NM_001180989.2_VR1 | cds-NP_011391.2_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:267080-269014:- | gene-YGL124C_ZTW1 | rna-NM_001180989.2_ZTW1 | cds-NP_011391.2_ZTW1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:273096-275030:- | gene-YGL124C_Sparadoxus | rna-NM_001180989.2_Sparadoxus | cds-NP_011391.2_Sparadoxus | 89.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |