Gene name: MOD5
Reference locus (S288C): YOR274W
Gene biotype: protein_coding
Description: Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects
Top 10 interactors (score): TRM1 (0.95); SMM1 (0.931); FMT1 (0.921); TRM7 (0.895); TRM5 (0.889); PUS7 (0.884); TRM10 (0.884); SUA5 (0.854); NCL1 (0.852); DEG1 (0.849); TRM9 (0.836); ELP3 (0.83); RNQ1 (0.816); SUP35 (0.81); TRM8 (0.81); TAD3 (0.8); TRM3 (0.773); PUS1 (0.773); URE2 (0.771); VAS1 (0.766)
Homologues (species, bitscore): TRIT1 (Homo sapiens, 224.2); Trit1 (Mus musculus, 226.5); trit1 (Danio rerio, 193.0); trit1 (Xenopus tropicalis, 226.1); BEST:LD10347 (Drosophila melanogaster, 198.0); gro-1 (Caenorhabditis elegans, 193.0); IPT2 (Arabidopsis thaliana, 162.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:828484-829770:+ | gene-YOR274W_AKU4011 | rna-NM_001183693.3_AKU4011 | cds-NP_014917.3_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:230448-231734:+ | gene-YOR274W_BG1 | rna-NM_001183693.3_BG1 | cds-NP_014917.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:813918-815204:+ | gene-YOR274W_Bruggeman | rna-NM_001183693.3_Bruggeman | cds-NP_014917.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:814589-815875:+ | gene-YOR274W_CAT1 | rna-NM_001183693.3_CAT1 | cds-NP_014917.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:811502-812788:+ | gene-YOR274W_CBS1585 | rna-NM_001183693.3_CBS1585 | cds-NP_014917.3_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:810150-811436:+ | gene-YOR274W_CBS436 | rna-NM_001183693.3_CBS436 | cds-NP_014917.3_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:808355-809641:+ | gene-YOR274W_CBS6412 | rna-NM_001183693.3_CBS6412 | cds-NP_014917.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:817213-818499:+ | gene-YOR274W_CBS6413 | rna-NM_001183693.3_CBS6413 | cds-NP_014917.3_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:837444-838730:+ | gene-YOR274W_CENPK1137D | rna-NM_001183693.3_CENPK1137D | cds-NP_014917.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:804611-805897:+ | gene-YOR274W_EthanolRed | rna-NM_001183693.3_EthanolRed | cds-NP_014917.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:810010-811296:+ | gene-YOR274W_FaliES1 | rna-NM_001183693.3_FaliES1 | cds-NP_014917.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:15619-16905:- | gene-YOR274W_JAY291 | rna-NM_001183693.3_JAY291 | cds-NP_014917.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:818155-819441:+ | gene-YOR274W_MUCL30387 | rna-NM_001183693.3_MUCL30387 | cds-NP_014917.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:826132-827418:+ | gene-YOR274W_MUCL30388 | rna-NM_001183693.3_MUCL30388 | cds-NP_014917.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:818848-820134:+ | gene-YOR274W_MUCL39482 | rna-NM_001183693.3_MUCL39482 | cds-NP_014917.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:828334-829620:+ | gene-YOR274W_MUCL42920 | rna-NM_001183693.3_MUCL42920 | cds-NP_014917.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:837563-838849:+ | gene-YOR274W_NCIM3186 | rna-NM_001183693.3_NCIM3186 | cds-NP_014917.3_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:819053-820339:+ | gene-YOR274W_NCYC1407 | rna-NM_001183693.3_NCYC1407 | cds-NP_014917.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:818130-819416:+ | gene-YOR274W_PE2H3 | rna-NM_001183693.3_PE2H3 | cds-NP_014917.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:828507-829793:+ | gene-YOR274W_PE2H4 | rna-NM_001183693.3_PE2H4 | cds-NP_014917.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:837674-838960:+ | gene-YOR274W_S288C | rna-NM_001183693.3_S288C | cds-NP_014917.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:247691-248977:+ | gene-YOR274W_SA1 | rna-NM_001183693.3_SA1 | cds-NP_014917.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:809193-810479:+ | gene-YOR274W_ThermosaccDry | rna-NM_001183693.3_ThermosaccDry | cds-NP_014917.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:872570-873856:+ | gene-YOR274W_VR1 | rna-NM_001183693.3_VR1 | cds-NP_014917.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:542081-543367:+ | gene-YOR274W_ZTW1 | rna-NM_001183693.3_ZTW1 | cds-NP_014917.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:814832-816118:+ | gene-YOR274W_Sparadoxus | rna-NM_001183693.3_Sparadoxus | cds-NP_014917.3_Sparadoxus | 88.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |