Gene name: MNS1
Reference locus (S288C): YJR131W
Gene biotype: protein_coding
Description: Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation; Belongs to the glycosyl hydrolase 47 family
Top 10 interactors (score): MNL2 (0.995); RER1 (0.954); ROT2 (0.952); ALG9 (0.945); CWH41 (0.939); YOS9 (0.927); GTB1 (0.9); AMS1 (0.885); PMT2 (0.855); WBP1 (0.824); KRE5 (0.824); ALG3 (0.82); OCH1 (0.801); EMP24 (0.788); SOG2 (0.788); HRD3 (0.763); STT3 (0.751); CNE1 (0.751); PSA1 (0.744); OST3 (0.73)
Homologues (species, bitscore): MAN1B1 (Homo sapiens, 303.5); Man1b1 (Mus musculus, 311.6); man1b1a (Danio rerio, 304.3); man1a2 (Xenopus tropicalis, 267.3); alpha-Man-Ib (Drosophila melanogaster, 268.1); ZC410.3 (Caenorhabditis elegans, 285.4); MNS3 (Arabidopsis thaliana, 342.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:639144-640793:+ | gene-YJR131W_AKU4011 | rna-NM_001181789.3_AKU4011 | cds-NP_012665.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000076.1:32808-34457:- | gene-YJR131W_BG1 | rna-NM_001181789.3_BG1 | cds-NP_012665.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:654873-656522:+ | gene-YJR131W_Bruggeman | rna-NM_001181789.3_Bruggeman | cds-NP_012665.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:659512-661161:+ | gene-YJR131W_CAT1 | rna-NM_001181789.3_CAT1 | cds-NP_012665.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:651188-652837:+ | gene-YJR131W_CBS1585 | rna-NM_001181789.3_CBS1585 | cds-NP_012665.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:670059-671708:+ | gene-YJR131W_CBS436 | rna-NM_001181789.3_CBS436 | cds-NP_012665.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:637965-639614:+ | gene-YJR131W_CBS6412 | rna-NM_001181789.3_CBS6412 | cds-NP_012665.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:640622-642271:+ | gene-YJR131W_CBS6413 | rna-NM_001181789.3_CBS6413 | cds-NP_012665.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:650004-651653:+ | gene-YJR131W_CENPK1137D | rna-NM_001181789.3_CENPK1137D | cds-NP_012665.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:643564-645213:+ | gene-YJR131W_EthanolRed | rna-NM_001181789.3_EthanolRed | cds-NP_012665.3_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:655027-656676:+ | gene-YJR131W_FaliES1 | rna-NM_001181789.3_FaliES1 | cds-NP_012665.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:32482-34131:- | gene-YJR131W_JAY291 | rna-NM_001181789.3_JAY291 | cds-NP_012665.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:653905-655554:+ | gene-YJR131W_MUCL30387 | rna-NM_001181789.3_MUCL30387 | cds-NP_012665.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:651387-653036:+ | gene-YJR131W_MUCL30388 | rna-NM_001181789.3_MUCL30388 | cds-NP_012665.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:644673-646322:+ | gene-YJR131W_MUCL39482 | rna-NM_001181789.3_MUCL39482 | cds-NP_012665.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:649410-651059:+ | gene-YJR131W_MUCL42920 | rna-NM_001181789.3_MUCL42920 | cds-NP_012665.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:667623-669272:+ | gene-YJR131W_NCIM3186 | rna-NM_001181789.3_NCIM3186 | cds-NP_012665.3_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:642222-643871:+ | gene-YJR131W_NCYC1407 | rna-NM_001181789.3_NCYC1407 | cds-NP_012665.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:660411-662060:+ | gene-YJR131W_PE2H3 | rna-NM_001181789.3_PE2H3 | cds-NP_012665.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:654100-655749:+ | gene-YJR131W_PE2H4 | rna-NM_001181789.3_PE2H4 | cds-NP_012665.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:667644-669293:+ | gene-YJR131W_S288C | rna-NM_001181789.3_S288C | cds-NP_012665.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000069.1:32833-34482:- | gene-YJR131W_SA1 | rna-NM_001181789.3_SA1 | cds-NP_012665.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:648958-650607:+ | gene-YJR131W_ThermosaccDry | rna-NM_001181789.3_ThermosaccDry | cds-NP_012665.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:651331-652980:+ | gene-YJR131W_VR1 | rna-NM_001181789.3_VR1 | cds-NP_012665.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:628308-629957:+ | gene-YJR131W_ZTW1 | rna-NM_001181789.3_ZTW1 | cds-NP_012665.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:662487-664136:+ | gene-YJR131W_Sparadoxus | rna-NM_001181789.3_Sparadoxus | cds-NP_012665.3_Sparadoxus | 88.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |