Gene name: MNL1
Reference locus (S288C): YHR204W
Gene biotype: protein_coding
Description: ER degradation-enhancing alpha-mannosidase-like protein 1; Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant
Top 10 interactors (score): PDI1 (0.998); YOS9 (0.997); HRD3 (0.98); HRD1 (0.979); RER1 (0.96); DER1 (0.958); CNE1 (0.955); KAR2 (0.937); ALG9 (0.932); CDC48 (0.906); AMS1 (0.901); SEC61 (0.893); MNL2 (0.87); ERV29 (0.847); UBC7 (0.845); SSM4 (0.839); STT3 (0.83); KRE5 (0.829); UFD1 (0.792); NPL4 (0.778)
Homologues (species, bitscore): EDEM1 (Homo sapiens, 352.8); Edem1 (Mus musculus, 354.0); edem1 (Danio rerio, 347.4); edem1 (Xenopus tropicalis, 350.9); Edem2 (Drosophila melanogaster, 293.5); C47E12.3 (Caenorhabditis elegans, 318.9); AT5G43710 (Arabidopsis thaliana, 296.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:493373-495763:+ | gene-YHR204W_AKU4011 | rna-NM_001179335.3_AKU4011 | cds-NP_012074.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:21965-24355:- | gene-YHR204W_BG1 | rna-NM_001179335.3_BG1 | cds-NP_012074.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:500886-503276:+ | gene-YHR204W_Bruggeman | rna-NM_001179335.3_Bruggeman | cds-NP_012074.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:497417-499807:+ | gene-YHR204W_CAT1 | rna-NM_001179335.3_CAT1 | cds-NP_012074.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:492826-495216:+ | gene-YHR204W_CBS1585 | rna-NM_001179335.3_CBS1585 | cds-NP_012074.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:490923-493313:+ | gene-YHR204W_CBS436 | rna-NM_001179335.3_CBS436 | cds-NP_012074.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:492925-495315:+ | gene-YHR204W_CBS6412 | rna-NM_001179335.3_CBS6412 | cds-NP_012074.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:494218-496608:+ | gene-YHR204W_CBS6413 | rna-NM_001179335.3_CBS6413 | cds-NP_012074.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:499505-501895:+ | gene-YHR204W_CENPK1137D | rna-NM_001179335.3_CENPK1137D | cds-NP_012074.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:551932-554322:+ | gene-YHR204W_EthanolRed | rna-NM_001179335.3_EthanolRed | cds-NP_012074.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:494376-496766:+ | gene-YHR204W_FaliES1 | rna-NM_001179335.3_FaliES1 | cds-NP_012074.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000071.1:1144-3534:+ | gene-YHR204W_JAY291 | rna-NM_001179335.3_JAY291 | cds-NP_012074.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:501960-504350:+ | gene-YHR204W_MUCL30387 | rna-NM_001179335.3_MUCL30387 | cds-NP_012074.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:501621-504011:+ | gene-YHR204W_MUCL30388 | rna-NM_001179335.3_MUCL30388 | cds-NP_012074.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:492931-495321:+ | gene-YHR204W_MUCL39482 | rna-NM_001179335.3_MUCL39482 | cds-NP_012074.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:508279-510669:+ | gene-YHR204W_MUCL42920 | rna-NM_001179335.3_MUCL42920 | cds-NP_012074.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:506201-508591:+ | gene-YHR204W_NCIM3186 | rna-NM_001179335.3_NCIM3186 | cds-NP_012074.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:495220-497610:+ | gene-YHR204W_NCYC1407 | rna-NM_001179335.3_NCYC1407 | cds-NP_012074.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:494381-496771:+ | gene-YHR204W_PE2H3 | rna-NM_001179335.3_PE2H3 | cds-NP_012074.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:501808-504198:+ | gene-YHR204W_PE2H4 | rna-NM_001179335.3_PE2H4 | cds-NP_012074.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:506319-508709:+ | gene-YHR204W_S288C | rna-NM_001179335.3_S288C | cds-NP_012074.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000112.1:1200-3590:+ | gene-YHR204W_SA1 | rna-NM_001179335.3_SA1 | cds-NP_012074.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:495644-498034:+ | gene-YHR204W_ThermosaccDry | rna-NM_001179335.3_ThermosaccDry | cds-NP_012074.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:504682-507072:+ | gene-YHR204W_VR1 | rna-NM_001179335.3_VR1 | cds-NP_012074.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:485695-488085:+ | gene-YHR204W_ZTW1 | rna-NM_001179335.3_ZTW1 | cds-NP_012074.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:492388-494781:+ | gene-YHR204W_Sparadoxus | rna-NM_001179335.3_Sparadoxus | cds-NP_012074.3_Sparadoxus | 87.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |