Gene name: MMS21
Reference locus (S288C): YEL019C
Gene biotype: protein_coding
Description: Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function; Belongs to the NSE2 family
Top 10 interactors (score): UBC9 (0.999); NSE4 (0.999); NSE1 (0.999); NSE3 (0.999); SMT3 (0.999); SMC6 (0.999); SMC5 (0.999); NFI1 (0.996); SIZ1 (0.995); NSE5 (0.992); UBA2 (0.989); SMC3 (0.988); KRE29 (0.988); ULP2 (0.981); AOS1 (0.976); ULP1 (0.962); CST9 (0.956); SGS1 (0.955); SMC1 (0.953); MEC1 (0.952)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:114528-115331:- | gene-YEL019C_AKU4011 | rna-NM_001178834.3_AKU4011 | cds-NP_010896.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:310636-311439:+ | gene-YEL019C_BG1 | rna-NM_001178834.3_BG1 | cds-NP_010896.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:121057-121860:- | gene-YEL019C_Bruggeman | rna-NM_001178834.3_Bruggeman | cds-NP_010896.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:116710-117513:- | gene-YEL019C_CAT1 | rna-NM_001178834.3_CAT1 | cds-NP_010896.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:114470-115273:- | gene-YEL019C_CBS1585 | rna-NM_001178834.3_CBS1585 | cds-NP_010896.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:116104-116907:- | gene-YEL019C_CBS436 | rna-NM_001178834.3_CBS436 | cds-NP_010896.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:114748-115551:- | gene-YEL019C_CBS6412 | rna-NM_001178834.3_CBS6412 | cds-NP_010896.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:119355-120158:- | gene-YEL019C_CBS6413 | rna-NM_001178834.3_CBS6413 | cds-NP_010896.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:118356-119159:- | gene-YEL019C_CENPK1137D | rna-NM_001178834.3_CENPK1137D | cds-NP_010896.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:114849-115652:- | gene-YEL019C_EthanolRed | rna-NM_001178834.3_EthanolRed | cds-NP_010896.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:115108-115911:- | gene-YEL019C_FaliES1 | rna-NM_001178834.3_FaliES1 | cds-NP_010896.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000398.1:33995-34798:- | gene-YEL019C_JAY291 | rna-NM_001178834.3_JAY291 | cds-NP_010896.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:118777-119580:- | gene-YEL019C_MUCL30387 | rna-NM_001178834.3_MUCL30387 | cds-NP_010896.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:114747-115550:- | gene-YEL019C_MUCL30388 | rna-NM_001178834.3_MUCL30388 | cds-NP_010896.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:113832-114635:- | gene-YEL019C_MUCL39482 | rna-NM_001178834.3_MUCL39482 | cds-NP_010896.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:118462-119265:- | gene-YEL019C_MUCL42920 | rna-NM_001178834.3_MUCL42920 | cds-NP_010896.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:120497-121300:- | gene-YEL019C_NCIM3186 | rna-NM_001178834.3_NCIM3186 | cds-NP_010896.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:118937-119740:- | gene-YEL019C_NCYC1407 | rna-NM_001178834.3_NCYC1407 | cds-NP_010896.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:122962-123765:- | gene-YEL019C_PE2H3 | rna-NM_001178834.3_PE2H3 | cds-NP_010896.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:118877-119680:- | gene-YEL019C_PE2H4 | rna-NM_001178834.3_PE2H4 | cds-NP_010896.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:120498-121301:- | gene-YEL019C_S288C | rna-NM_001178834.3_S288C | cds-NP_010896.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:121920-122723:+ | gene-YEL019C_SA1 | rna-NM_001178834.3_SA1 | cds-NP_010896.3_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:115513-116316:- | gene-YEL019C_ThermosaccDry | rna-NM_001178834.3_ThermosaccDry | cds-NP_010896.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:115054-115857:- | gene-YEL019C_VR1 | rna-NM_001178834.3_VR1 | cds-NP_010896.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:113875-114678:- | gene-YEL019C_ZTW1 | rna-NM_001178834.3_ZTW1 | cds-NP_010896.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:117323-118126:- | gene-YEL019C_Sparadoxus | rna-NM_001178834.3_Sparadoxus | cds-NP_010896.3_Sparadoxus | 88.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |