Gene name: MLS1
Reference locus (S288C): YNL117W
Gene biotype: protein_coding
Description: Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA
Top 10 interactors (score): PCK1 (0.999); ICL1 (0.999); ACS1 (0.998); CIT2 (0.994); MDH2 (0.994); FBP1 (0.994); ICL2 (0.993); ACH1 (0.99); CIT3 (0.989); CIT1 (0.988); IDP2 (0.986); FUM1 (0.985); MDH3 (0.985); MDH1 (0.985); AGX1 (0.982); SFC1 (0.981); ACS2 (0.98); GOR1 (0.974); LSC1 (0.972); ACO1 (0.97)
Homologues (species, bitscore): LOC564844 (Danio rerio, 326.6); ENSXETP00000036832 (Xenopus tropicalis, 325.1); icl-1 (Caenorhabditis elegans, 496.1); MLS (Arabidopsis thaliana, 493.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:400040-401704:+ | gene-YNL117W_AKU4011 | rna-NM_001182955.1_AKU4011 | cds-NP_014282.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:304034-305698:+ | gene-YNL117W_BG1 | rna-NM_001182955.1_BG1 | cds-NP_014282.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:410506-412170:+ | gene-YNL117W_Bruggeman | rna-NM_001182955.1_Bruggeman | cds-NP_014282.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:453804-455468:+ | gene-YNL117W_CAT1 | rna-NM_001182955.1_CAT1 | cds-NP_014282.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:400660-402324:+ | gene-YNL117W_CBS1585 | rna-NM_001182955.1_CBS1585 | cds-NP_014282.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:469069-470733:+ | gene-YNL117W_CBS436 | rna-NM_001182955.1_CBS436 | cds-NP_014282.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:396113-397777:+ | gene-YNL117W_CBS6412 | rna-NM_001182955.1_CBS6412 | cds-NP_014282.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:397078-398742:+ | gene-YNL117W_CBS6413 | rna-NM_001182955.1_CBS6413 | cds-NP_014282.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:400208-401872:+ | gene-YNL117W_CENPK1137D | rna-NM_001182955.1_CENPK1137D | cds-NP_014282.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:397030-398694:+ | gene-YNL117W_EthanolRed | rna-NM_001182955.1_EthanolRed | cds-NP_014282.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:392932-394596:+ | gene-YNL117W_FaliES1 | rna-NM_001182955.1_FaliES1 | cds-NP_014282.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000021.1:49311-50975:+ | gene-YNL117W_JAY291 | rna-NM_001182955.1_JAY291 | cds-NP_014282.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:406925-408589:+ | gene-YNL117W_MUCL30387 | rna-NM_001182955.1_MUCL30387 | cds-NP_014282.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:442104-443768:+ | gene-YNL117W_MUCL30388 | rna-NM_001182955.1_MUCL30388 | cds-NP_014282.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:397939-399603:+ | gene-YNL117W_MUCL39482 | rna-NM_001182955.1_MUCL39482 | cds-NP_014282.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:401179-402843:+ | gene-YNL117W_MUCL42920 | rna-NM_001182955.1_MUCL42920 | cds-NP_014282.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:406327-407991:+ | gene-YNL117W_NCIM3186 | rna-NM_001182955.1_NCIM3186 | cds-NP_014282.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:400071-401735:+ | gene-YNL117W_NCYC1407 | rna-NM_001182955.1_NCYC1407 | cds-NP_014282.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:399060-400724:+ | gene-YNL117W_PE2H3 | rna-NM_001182955.1_PE2H3 | cds-NP_014282.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:398466-400130:+ | gene-YNL117W_PE2H4 | rna-NM_001182955.1_PE2H4 | cds-NP_014282.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:406358-408022:+ | gene-YNL117W_S288C | rna-NM_001182955.1_S288C | cds-NP_014282.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000018.1:5507-7171:- | gene-YNL117W_SA1 | rna-NM_001182955.1_SA1 | cds-NP_014282.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:393786-395450:+ | gene-YNL117W_ThermosaccDry | rna-NM_001182955.1_ThermosaccDry | cds-NP_014282.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:412449-414113:+ | gene-YNL117W_VR1 | rna-NM_001182955.1_VR1 | cds-NP_014282.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:303619-305283:+ | gene-YNL117W_ZTW1 | rna-NM_001182955.1_ZTW1 | cds-NP_014282.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:404626-406290:+ | gene-YNL117W_Sparadoxus | rna-NM_001182955.1_Sparadoxus | cds-NP_014282.1_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |