Gene name: MLH3
Reference locus (S288C): YPL164C
Gene biotype: protein_coding
Description: Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability; Belongs to the DNA mismatch repair MutL/HexB family
Top 10 interactors (score): MSH6 (0.998); MSH3 (0.997); MSH2 (0.997); MSH5 (0.995); MSH4 (0.993); MLH1 (0.991); EXO1 (0.987); MUS81 (0.98); SGS1 (0.97); MND1 (0.943); PCH2 (0.941); YEN1 (0.94); SPO11 (0.926); HFM1 (0.921); PMS1 (0.906); MSH1 (0.897); RAD10 (0.892); RAD51 (0.886); DMC1 (0.881); RAD2 (0.881)
Homologues (species, bitscore): MLH3 (Homo sapiens, 119.0); Mlh3 (Mus musculus, 122.9); mlh3 (Danio rerio, 106.3); mlh3 (Xenopus tropicalis, 134.4); Mlh1 (Drosophila melanogaster, 106.7); mlh-1 (Caenorhabditis elegans, 99.4); PMS1 (Arabidopsis thaliana, 106.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:217015-219162:- | gene-YPL164C_AKU4011 | rna-NM_001183978.1_AKU4011 | cds-NP_015161.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:422685-424832:- | gene-YPL164C_BG1 | rna-NM_001183978.1_BG1 | cds-NP_015161.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:243005-245152:- | gene-YPL164C_Bruggeman | rna-NM_001183978.1_Bruggeman | cds-NP_015161.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:239674-241821:- | gene-YPL164C_CAT1 | rna-NM_001183978.1_CAT1 | cds-NP_015161.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:221081-223228:- | gene-YPL164C_CBS1585 | rna-NM_001183978.1_CBS1585 | cds-NP_015161.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:235737-237884:- | gene-YPL164C_CBS436 | rna-NM_001183978.1_CBS436 | cds-NP_015161.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:225756-227903:- | gene-YPL164C_CBS6412 | rna-NM_001183978.1_CBS6412 | cds-NP_015161.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:217716-219863:- | gene-YPL164C_CBS6413 | rna-NM_001183978.1_CBS6413 | cds-NP_015161.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:239234-241381:- | gene-YPL164C_CENPK1137D | rna-NM_001183978.1_CENPK1137D | cds-NP_015161.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:215759-217906:- | gene-YPL164C_EthanolRed | rna-NM_001183978.1_EthanolRed | cds-NP_015161.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:223351-225498:- | gene-YPL164C_FaliES1 | rna-NM_001183978.1_FaliES1 | cds-NP_015161.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:140411-142558:+ | gene-YPL164C_JAY291 | rna-NM_001183978.1_JAY291 | cds-NP_015161.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:234249-236396:- | gene-YPL164C_MUCL30387 | rna-NM_001183978.1_MUCL30387 | cds-NP_015161.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:232262-234409:- | gene-YPL164C_MUCL30388 | rna-NM_001183978.1_MUCL30388 | cds-NP_015161.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:214410-216557:- | gene-YPL164C_MUCL39482 | rna-NM_001183978.1_MUCL39482 | cds-NP_015161.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:271137-273284:- | gene-YPL164C_MUCL42920 | rna-NM_001183978.1_MUCL42920 | cds-NP_015161.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:239333-241480:- | gene-YPL164C_NCIM3186 | rna-NM_001183978.1_NCIM3186 | cds-NP_015161.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:220864-223011:- | gene-YPL164C_NCYC1407 | rna-NM_001183978.1_NCYC1407 | cds-NP_015161.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:228299-230446:- | gene-YPL164C_PE2H3 | rna-NM_001183978.1_PE2H3 | cds-NP_015161.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:227942-230089:- | gene-YPL164C_PE2H4 | rna-NM_001183978.1_PE2H4 | cds-NP_015161.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:239350-241497:- | gene-YPL164C_S288C | rna-NM_001183978.1_S288C | cds-NP_015161.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:132186-134333:+ | gene-YPL164C_SA1 | rna-NM_001183978.1_SA1 | cds-NP_015161.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:223149-225296:- | gene-YPL164C_ThermosaccDry | rna-NM_001183978.1_ThermosaccDry | cds-NP_015161.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:238070-240217:- | gene-YPL164C_VR1 | rna-NM_001183978.1_VR1 | cds-NP_015161.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:222477-224624:- | gene-YPL164C_ZTW1 | rna-NM_001183978.1_ZTW1 | cds-NP_015161.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:224043-226190:- | gene-YPL164C_Sparadoxus | rna-NM_001183978.1_Sparadoxus | cds-NP_015161.1_Sparadoxus | 86.0 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |