Gene name: MLH1
Reference locus (S288C): YMR167W
Gene biotype: protein_coding
Description: Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; Belongs to the DNA mismatch repair MutL/HexB family
Top 10 interactors (score): MSH2 (0.999); PMS1 (0.999); EXO1 (0.999); MSH6 (0.999); MSH3 (0.999); SGS1 (0.999); MSH5 (0.996); MSH4 (0.996); MLH3 (0.991); RAD51 (0.989); MUS81 (0.985); POL3 (0.978); SPO11 (0.978); RAD2 (0.975); NTG2 (0.967); RAD1 (0.966); MND1 (0.959); DMC1 (0.959); YEN1 (0.954); RAD10 (0.95)
Homologues (species, bitscore): MLH1 (Homo sapiens, 503.1); Mlh1 (Mus musculus, 499.2); mlh1 (Danio rerio, 500.0); MLH1 (Xenopus tropicalis, 492.7); Mlh1 (Drosophila melanogaster, 450.3); mlh-1 (Caenorhabditis elegans, 342.0); MLH1 (Arabidopsis thaliana, 395.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:634635-636944:+ | gene-YMR167W_AKU4011 | rna-NM_001182671.1_AKU4011 | cds-NP_013890.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000068.1:35885-38194:- | gene-YMR167W_BG1 | rna-NM_001182671.1_BG1 | cds-NP_013890.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:577563-579872:+ | gene-YMR167W_Bruggeman | rna-NM_001182671.1_Bruggeman | cds-NP_013890.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:580565-582874:+ | gene-YMR167W_CAT1 | rna-NM_001182671.1_CAT1 | cds-NP_013890.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:567316-569625:+ | gene-YMR167W_CBS1585 | rna-NM_001182671.1_CBS1585 | cds-NP_013890.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:571181-573490:+ | gene-YMR167W_CBS436 | rna-NM_001182671.1_CBS436 | cds-NP_013890.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:679933-682242:+ | gene-YMR167W_CBS6412 | rna-NM_001182671.1_CBS6412 | cds-NP_013890.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:565866-568175:+ | gene-YMR167W_CBS6413 | rna-NM_001182671.1_CBS6413 | cds-NP_013890.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:589365-591674:+ | gene-YMR167W_CENPK1137D | rna-NM_001182671.1_CENPK1137D | cds-NP_013890.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:627491-629800:+ | gene-YMR167W_EthanolRed | rna-NM_001182671.1_EthanolRed | cds-NP_013890.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:572645-574954:+ | gene-YMR167W_FaliES1 | rna-NM_001182671.1_FaliES1 | cds-NP_013890.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000292.1:2769-5078:- | gene-YMR167W_JAY291 | rna-NM_001182671.1_JAY291 | cds-NP_013890.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:572537-574846:+ | gene-YMR167W_MUCL30387 | rna-NM_001182671.1_MUCL30387 | cds-NP_013890.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:578190-580499:+ | gene-YMR167W_MUCL30388 | rna-NM_001182671.1_MUCL30388 | cds-NP_013890.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:568002-570311:+ | gene-YMR167W_MUCL39482 | rna-NM_001182671.1_MUCL39482 | cds-NP_013890.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:574830-577139:+ | gene-YMR167W_MUCL42920 | rna-NM_001182671.1_MUCL42920 | cds-NP_013890.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:594840-597149:+ | gene-YMR167W_NCIM3186 | rna-NM_001182671.1_NCIM3186 | cds-NP_013890.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:567704-570013:+ | gene-YMR167W_NCYC1407 | rna-NM_001182671.1_NCYC1407 | cds-NP_013890.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:578046-580355:+ | gene-YMR167W_PE2H3 | rna-NM_001182671.1_PE2H3 | cds-NP_013890.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:578508-580817:+ | gene-YMR167W_PE2H4 | rna-NM_001182671.1_PE2H4 | cds-NP_013890.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:594886-597195:+ | gene-YMR167W_S288C | rna-NM_001182671.1_S288C | cds-NP_013890.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:209064-211373:- | gene-YMR167W_SA1 | rna-NM_001182671.1_SA1 | cds-NP_013890.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:568377-570686:+ | gene-YMR167W_ThermosaccDry | rna-NM_001182671.1_ThermosaccDry | cds-NP_013890.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:580532-582841:+ | gene-YMR167W_VR1 | rna-NM_001182671.1_VR1 | cds-NP_013890.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:543000-545309:+ | gene-YMR167W_ZTW1 | rna-NM_001182671.1_ZTW1 | cds-NP_013890.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:586661-588970:+ | gene-YMR167W_Sparadoxus | rna-NM_001182671.1_Sparadoxus | cds-NP_013890.1_Sparadoxus | 88.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |