Gene name: MKK2
Reference locus (S288C): YPL140C
Gene biotype: protein_coding
Description: MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
Top 10 interactors (score): BCK1 (0.998); SLT2 (0.996); KDX1 (0.983); MKK1 (0.978); HOG1 (0.97); STE11 (0.968); SMK1 (0.958); RHO1 (0.951); SPA2 (0.916); SLG1 (0.909); MSS4 (0.908); FUS3 (0.875); KSS1 (0.868); RLM1 (0.863); ROM2 (0.832); MID2 (0.766); YNL217W (0.753); ROM1 (0.735); PKC1 (0.729); RHO2 (0.723)
Homologues (species, bitscore): MAP2K5 (Homo sapiens, 209.9); Map2k5 (Mus musculus, 209.9); map2k5 (Danio rerio, 208.8); map2k5 (Xenopus tropicalis, 201.4); Dsor1 (Drosophila melanogaster, 216.9); mek-2 (Caenorhabditis elegans, 182.2); MKK3 (Arabidopsis thaliana, 190.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:265168-266687:- | gene-YPL140C_AKU4011 | rna-NM_001183954.1_AKU4011 | cds-NP_015185.1_AKU4011 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:470854-472374:- | gene-YPL140C_BG1 | rna-NM_001183954.1_BG1 | cds-NP_015185.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:291163-292683:- | gene-YPL140C_Bruggeman | rna-NM_001183954.1_Bruggeman | cds-NP_015185.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:287841-289361:- | gene-YPL140C_CAT1 | rna-NM_001183954.1_CAT1 | cds-NP_015185.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:269234-270754:- | gene-YPL140C_CBS1585 | rna-NM_001183954.1_CBS1585 | cds-NP_015185.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:283905-285425:- | gene-YPL140C_CBS436 | rna-NM_001183954.1_CBS436 | cds-NP_015185.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:273909-275429:- | gene-YPL140C_CBS6412 | rna-NM_001183954.1_CBS6412 | cds-NP_015185.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:265873-267393:- | gene-YPL140C_CBS6413 | rna-NM_001183954.1_CBS6413 | cds-NP_015185.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:287416-288936:- | gene-YPL140C_CENPK1137D | rna-NM_001183954.1_CENPK1137D | cds-NP_015185.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:263857-265377:- | gene-YPL140C_EthanolRed | rna-NM_001183954.1_EthanolRed | cds-NP_015185.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:271449-272969:- | gene-YPL140C_FaliES1 | rna-NM_001183954.1_FaliES1 | cds-NP_015185.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:92879-94399:+ | gene-YPL140C_JAY291 | rna-NM_001183954.1_JAY291 | cds-NP_015185.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:282407-283927:- | gene-YPL140C_MUCL30387 | rna-NM_001183954.1_MUCL30387 | cds-NP_015185.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:280420-281940:- | gene-YPL140C_MUCL30388 | rna-NM_001183954.1_MUCL30388 | cds-NP_015185.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:262563-264083:- | gene-YPL140C_MUCL39482 | rna-NM_001183954.1_MUCL39482 | cds-NP_015185.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:319804-321324:- | gene-YPL140C_MUCL42920 | rna-NM_001183954.1_MUCL42920 | cds-NP_015185.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:287497-289017:- | gene-YPL140C_NCIM3186 | rna-NM_001183954.1_NCIM3186 | cds-NP_015185.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:269023-270543:- | gene-YPL140C_NCYC1407 | rna-NM_001183954.1_NCYC1407 | cds-NP_015185.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:276469-277989:- | gene-YPL140C_PE2H3 | rna-NM_001183954.1_PE2H3 | cds-NP_015185.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:276104-277624:- | gene-YPL140C_PE2H4 | rna-NM_001183954.1_PE2H4 | cds-NP_015185.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:287514-289034:- | gene-YPL140C_S288C | rna-NM_001183954.1_S288C | cds-NP_015185.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:84649-86169:+ | gene-YPL140C_SA1 | rna-NM_001183954.1_SA1 | cds-NP_015185.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:271247-272767:- | gene-YPL140C_ThermosaccDry | rna-NM_001183954.1_ThermosaccDry | cds-NP_015185.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:286225-287745:- | gene-YPL140C_VR1 | rna-NM_001183954.1_VR1 | cds-NP_015185.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:270577-272097:- | gene-YPL140C_ZTW1 | rna-NM_001183954.1_ZTW1 | cds-NP_015185.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:272252-273782:- | gene-YPL140C_Sparadoxus | rna-NM_001183954.1_Sparadoxus | cds-NP_015185.1_Sparadoxus | 87.6 | 99.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |