Gene name: MIS1
Reference locus (S288C): YBR084W
Gene biotype: protein_coding
Description: Trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase mis1; C-1-tetrahydrofolate synthase, mitochondrial; Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
Top 10 interactors (score): SHM1 (0.993); GCV1 (0.991); MET7 (0.986); ADE8 (0.986); SHM2 (0.985); FMT1 (0.978); RMA1 (0.975); MET12 (0.975); MET13 (0.972); ADE16 (0.971); DFR1 (0.971); ADE17 (0.971); CDC21 (0.966); FAU1 (0.963); ADE3 (0.948); MTD1 (0.944); ADE5,7 (0.892); FOL2 (0.815); FOL1 (0.79); ENP1 (0.777)
Homologues (species, bitscore): MTHFD1 (Homo sapiens, 1052.7); Mthfd1 (Mus musculus, 1043.1); mthfd1b (Danio rerio, 1045.8); mthfd1l (Xenopus tropicalis, 831.2); pug (Drosophila melanogaster, 1021.9); K07E3.4 (Caenorhabditis elegans, 746.1); THFS (Arabidopsis thaliana, 709.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:393428-396355:+ | gene-YBR084W_AKU4011 | rna-NM_001178432.1_AKU4011 | cds-NP_009640.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:384414-387341:+ | gene-YBR084W_BG1 | rna-NM_001178432.1_BG1 | cds-NP_009640.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:395004-397931:+ | gene-YBR084W_Bruggeman | rna-NM_001178432.1_Bruggeman | cds-NP_009640.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:397982-400909:+ | gene-YBR084W_CAT1 | rna-NM_001178432.1_CAT1 | cds-NP_009640.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:385713-388640:+ | gene-YBR084W_CBS1585 | rna-NM_001178432.1_CBS1585 | cds-NP_009640.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:393819-396746:+ | gene-YBR084W_CBS436 | rna-NM_001178432.1_CBS436 | cds-NP_009640.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:483943-486870:+ | gene-YBR084W_CBS6412 | rna-NM_001178432.1_CBS6412 | cds-NP_009640.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:390853-393780:+ | gene-YBR084W_CBS6413 | rna-NM_001178432.1_CBS6413 | cds-NP_009640.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:404813-407740:+ | gene-YBR084W_CENPK1137D | rna-NM_001178432.1_CENPK1137D | cds-NP_009640.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:520220-523147:+ | gene-YBR084W_EthanolRed | rna-NM_001178432.1_EthanolRed | cds-NP_009640.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:409503-412430:+ | gene-YBR084W_FaliES1 | rna-NM_001178432.1_FaliES1 | cds-NP_009640.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000013.1:14771-17698:- | gene-YBR084W_JAY291 | rna-NM_001178432.1_JAY291 | cds-NP_009640.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:396301-399228:+ | gene-YBR084W_MUCL30387 | rna-NM_001178432.1_MUCL30387 | cds-NP_009640.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:396234-399161:+ | gene-YBR084W_MUCL30388 | rna-NM_001178432.1_MUCL30388 | cds-NP_009640.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:385704-388631:+ | gene-YBR084W_MUCL39482 | rna-NM_001178432.1_MUCL39482 | cds-NP_009640.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:392916-395843:+ | gene-YBR084W_MUCL42920 | rna-NM_001178432.1_MUCL42920 | cds-NP_009640.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:410851-413778:+ | gene-YBR084W_NCIM3186 | rna-NM_001178432.1_NCIM3186 | cds-NP_009640.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:386636-389563:+ | gene-YBR084W_NCYC1407 | rna-NM_001178432.1_NCYC1407 | cds-NP_009640.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:399214-402141:+ | gene-YBR084W_PE2H3 | rna-NM_001178432.1_PE2H3 | cds-NP_009640.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:396890-399817:+ | gene-YBR084W_PE2H4 | rna-NM_001178432.1_PE2H4 | cds-NP_009640.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:411054-413981:+ | gene-YBR084W_S288C | rna-NM_001178432.1_S288C | cds-NP_009640.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000017.1:63534-66461:- | gene-YBR084W_SA1 | rna-NM_001178432.1_SA1 | cds-NP_009640.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:408510-411437:+ | gene-YBR084W_ThermosaccDry | rna-NM_001178432.1_ThermosaccDry | cds-NP_009640.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:390495-393422:+ | gene-YBR084W_VR1 | rna-NM_001178432.1_VR1 | cds-NP_009640.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:384178-387105:+ | gene-YBR084W_ZTW1 | rna-NM_001178432.1_ZTW1 | cds-NP_009640.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:421152-424079:+ | gene-YBR084W_Sparadoxus | rna-NM_001178432.1_Sparadoxus | cds-NP_009640.1_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |