Gene name: MIP1
Reference locus (S288C): YOR330C
Gene biotype: protein_coding
Description: Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases
Top 10 interactors (score): SOD2 (0.983); MRP1 (0.967); RSM26 (0.967); RPO41 (0.922); GRS2 (0.891); GRS1 (0.891); MSH1 (0.826); REV3 (0.815); COX3 (0.814); ATP6 (0.786); DNA2 (0.78); TRP5 (0.779); MGM101 (0.758); COX2 (0.739); RNH1 (0.705); RAD27 (0.705); REV1 (0.701); HMI1 (0.701); PRI1 (0.7); ALG13 (0.696)
Homologues (species, bitscore): POLG (Homo sapiens, 652.9); Polg (Mus musculus, 662.5); polg (Danio rerio, 646.4); Polg (Xenopus tropicalis, 647.1); tam (Drosophila melanogaster, 559.3); polg-1 (Caenorhabditis elegans, 377.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:930118-933882:- | gene-YOR330C_AKU4011 | rna-NM_001183750.1_AKU4011 | cds-NP_014975.2_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:332173-335937:- | gene-YOR330C_BG1 | rna-NM_001183750.1_BG1 | cds-NP_014975.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:915525-919289:- | gene-YOR330C_Bruggeman | rna-NM_001183750.1_Bruggeman | cds-NP_014975.2_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:916241-920005:- | gene-YOR330C_CAT1 | rna-NM_001183750.1_CAT1 | cds-NP_014975.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:913941-917705:- | gene-YOR330C_CBS1585 | rna-NM_001183750.1_CBS1585 | cds-NP_014975.2_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:911757-915521:- | gene-YOR330C_CBS436 | rna-NM_001183750.1_CBS436 | cds-NP_014975.2_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:909651-913415:- | gene-YOR330C_CBS6412 | rna-NM_001183750.1_CBS6412 | cds-NP_014975.2_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:918780-922544:- | gene-YOR330C_CBS6413 | rna-NM_001183750.1_CBS6413 | cds-NP_014975.2_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:939396-943160:- | gene-YOR330C_CENPK1137D | rna-NM_001183750.1_CENPK1137D | cds-NP_014975.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:906033-909797:- | gene-YOR330C_EthanolRed | rna-NM_001183750.1_EthanolRed | cds-NP_014975.2_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:911656-915420:- | gene-YOR330C_FaliES1 | rna-NM_001183750.1_FaliES1 | cds-NP_014975.2_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000078.1:87849-91613:+ | gene-YOR330C_JAY291 | rna-NM_001183750.1_JAY291 | cds-NP_014975.2_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:920010-923774:- | gene-YOR330C_MUCL30387 | rna-NM_001183750.1_MUCL30387 | cds-NP_014975.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:927782-931546:- | gene-YOR330C_MUCL30388 | rna-NM_001183750.1_MUCL30388 | cds-NP_014975.2_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:920486-924250:- | gene-YOR330C_MUCL39482 | rna-NM_001183750.1_MUCL39482 | cds-NP_014975.2_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:929940-933704:- | gene-YOR330C_MUCL42920 | rna-NM_001183750.1_MUCL42920 | cds-NP_014975.2_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:939510-943274:- | gene-YOR330C_NCIM3186 | rna-NM_001183750.1_NCIM3186 | cds-NP_014975.2_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:921486-925250:- | gene-YOR330C_NCYC1407 | rna-NM_001183750.1_NCYC1407 | cds-NP_014975.2_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:919706-923470:- | gene-YOR330C_PE2H3 | rna-NM_001183750.1_PE2H3 | cds-NP_014975.2_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:936058-939822:- | gene-YOR330C_PE2H4 | rna-NM_001183750.1_PE2H4 | cds-NP_014975.2_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:939621-943385:- | gene-YOR330C_S288C | rna-NM_001183750.1_S288C | cds-NP_014975.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000016.1:49949-53713:- | gene-YOR330C_SA1 | rna-NM_001183750.1_SA1 | cds-NP_014975.2_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:910839-914603:- | gene-YOR330C_ThermosaccDry | rna-NM_001183750.1_ThermosaccDry | cds-NP_014975.2_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:974126-977890:- | gene-YOR330C_VR1 | rna-NM_001183750.1_VR1 | cds-NP_014975.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:643710-647474:- | gene-YOR330C_ZTW1 | rna-NM_001183750.1_ZTW1 | cds-NP_014975.2_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:918078-921851:- | gene-YOR330C_Sparadoxus | rna-NM_001183750.1_Sparadoxus | cds-NP_014975.2_Sparadoxus | 89.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |