Gene name: MIA40
Reference locus (S288C): YKL195W
Gene biotype: protein_coding
Description: Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro
Top 10 interactors (score): COX17 (0.999); TIM10 (0.999); TIM9 (0.999); TIM13 (0.999); ERV1 (0.999); TIM8 (0.998); COX19 (0.998); ATP23 (0.996); MIX17 (0.989); TIM12 (0.987); MDM35 (0.984); MIC60 (0.984); CCS1 (0.981); COA4 (0.979); TOM40 (0.978); MIX14 (0.968); TOM22 (0.965); HOT13 (0.958); PET191 (0.955); TIM50 (0.951)
Homologues (species, bitscore): CHCHD4 (Homo sapiens, 102.1); Chchd4 (Mus musculus, 102.1); chchd4 (Danio rerio, 104.0); chchd4 (Xenopus tropicalis, 104.0); CG7950 (Drosophila melanogaster, 96.3); MIA40 (Arabidopsis thaliana, 63.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:62183-63394:+ | gene-YKL195W_AKU4011 | rna-NM_001179761.1_AKU4011 | cds-NP_012726.2_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:39149-40360:+ | gene-YKL195W_BG1 | rna-NM_001179761.1_BG1 | cds-NP_012726.2_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:79834-81045:+ | gene-YKL195W_Bruggeman | rna-NM_001179761.1_Bruggeman | cds-NP_012726.2_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:75006-76217:+ | gene-YKL195W_CAT1 | rna-NM_001179761.1_CAT1 | cds-NP_012726.2_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:74168-75379:+ | gene-YKL195W_CBS1585 | rna-NM_001179761.1_CBS1585 | cds-NP_012726.2_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:73399-74610:+ | gene-YKL195W_CBS436 | rna-NM_001179761.1_CBS436 | cds-NP_012726.2_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:59420-60631:+ | gene-YKL195W_CBS6412 | rna-NM_001179761.1_CBS6412 | cds-NP_012726.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:74805-76016:+ | gene-YKL195W_CBS6413 | rna-NM_001179761.1_CBS6413 | cds-NP_012726.2_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:75599-76810:+ | gene-YKL195W_CENPK1137D | rna-NM_001179761.1_CENPK1137D | cds-NP_012726.2_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:73616-74827:+ | gene-YKL195W_EthanolRed | rna-NM_001179761.1_EthanolRed | cds-NP_012726.2_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:73675-74886:+ | gene-YKL195W_FaliES1 | rna-NM_001179761.1_FaliES1 | cds-NP_012726.2_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:73232-74443:+ | gene-YKL195W_JAY291 | rna-NM_001179761.1_JAY291 | cds-NP_012726.2_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:82365-83576:+ | gene-YKL195W_MUCL30387 | rna-NM_001179761.1_MUCL30387 | cds-NP_012726.2_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:76457-77668:+ | gene-YKL195W_MUCL30388 | rna-NM_001179761.1_MUCL30388 | cds-NP_012726.2_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:74225-75436:+ | gene-YKL195W_MUCL39482 | rna-NM_001179761.1_MUCL39482 | cds-NP_012726.2_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:77767-78978:+ | gene-YKL195W_MUCL42920 | rna-NM_001179761.1_MUCL42920 | cds-NP_012726.2_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:75810-77021:+ | gene-YKL195W_NCIM3186 | rna-NM_001179761.1_NCIM3186 | cds-NP_012726.2_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:74249-75460:+ | gene-YKL195W_NCYC1407 | rna-NM_001179761.1_NCYC1407 | cds-NP_012726.2_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:81772-82983:+ | gene-YKL195W_PE2H3 | rna-NM_001179761.1_PE2H3 | cds-NP_012726.2_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:78066-79277:+ | gene-YKL195W_PE2H4 | rna-NM_001179761.1_PE2H4 | cds-NP_012726.2_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:75821-77032:+ | gene-YKL195W_S288C | rna-NM_001179761.1_S288C | cds-NP_012726.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000113.1:9701-10912:+ | gene-YKL195W_SA1 | rna-NM_001179761.1_SA1 | cds-NP_012726.2_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:74423-75634:+ | gene-YKL195W_ThermosaccDry | rna-NM_001179761.1_ThermosaccDry | cds-NP_012726.2_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:73478-74689:+ | gene-YKL195W_VR1 | rna-NM_001179761.1_VR1 | cds-NP_012726.2_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:73346-74557:+ | gene-YKL195W_ZTW1 | rna-NM_001179761.1_ZTW1 | cds-NP_012726.2_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:87661-88845:+ | gene-YKL195W_Sparadoxus | rna-NM_001179761.1_Sparadoxus | cds-NP_012726.2_Sparadoxus | 85.6 | 96.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |