Gene name: MGR2
Reference locus (S288C): YPL098C
Gene biotype: protein_coding
Description: Protein MGR2; Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their release into the inner membrane by the TIM23 complex; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
Top 10 interactors (score): TIM21 (0.996); TIM50 (0.993); TIM17 (0.99); TIM23 (0.985); TIM44 (0.984); PHB1 (0.976); PAM18 (0.975); PAM16 (0.972); COX12 (0.968); QCR9 (0.949); PAM17 (0.939); SSC1 (0.931); COX4 (0.905); RPB10 (0.896); TOM7 (0.892); MGE1 (0.89); QCR8 (0.883); TOM22 (0.842); MDJ2 (0.801); TIM13 (0.78)
Homologues (species, bitscore): ROMO1 (Homo sapiens, 57.4); Romo1 (Mus musculus, 57.4); ROMO1 (Danio rerio, 56.2); romo1 (Xenopus tropicalis, 57.8); CG6878 (Drosophila melanogaster, 57.4); rmo-1 (Caenorhabditis elegans, 56.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:342028-342369:- | gene-YPL098C_AKU4011 | rna-NM_001183912.1_AKU4011 | cds-NP_015227.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:547781-548122:- | gene-YPL098C_BG1 | rna-NM_001183912.1_BG1 | cds-NP_015227.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:368034-368375:- | gene-YPL098C_Bruggeman | rna-NM_001183912.1_Bruggeman | cds-NP_015227.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:365498-365839:- | gene-YPL098C_CAT1 | rna-NM_001183912.1_CAT1 | cds-NP_015227.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:346101-346442:- | gene-YPL098C_CBS1585 | rna-NM_001183912.1_CBS1585 | cds-NP_015227.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:360773-361114:- | gene-YPL098C_CBS436 | rna-NM_001183912.1_CBS436 | cds-NP_015227.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:350770-351111:- | gene-YPL098C_CBS6412 | rna-NM_001183912.1_CBS6412 | cds-NP_015227.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:342737-343078:- | gene-YPL098C_CBS6413 | rna-NM_001183912.1_CBS6413 | cds-NP_015227.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:364334-364675:- | gene-YPL098C_CENPK1137D | rna-NM_001183912.1_CENPK1137D | cds-NP_015227.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:340720-341061:- | gene-YPL098C_EthanolRed | rna-NM_001183912.1_EthanolRed | cds-NP_015227.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:348312-348653:- | gene-YPL098C_FaliES1 | rna-NM_001183912.1_FaliES1 | cds-NP_015227.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:17165-17506:+ | gene-YPL098C_JAY291 | rna-NM_001183912.1_JAY291 | cds-NP_015227.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:359272-359613:- | gene-YPL098C_MUCL30387 | rna-NM_001183912.1_MUCL30387 | cds-NP_015227.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:583790-584131:- | gene-YPL098C_MUCL30388 | rna-NM_001183912.1_MUCL30388 | cds-NP_015227.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:339430-339771:- | gene-YPL098C_MUCL39482 | rna-NM_001183912.1_MUCL39482 | cds-NP_015227.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:397118-397459:- | gene-YPL098C_MUCL42920 | rna-NM_001183912.1_MUCL42920 | cds-NP_015227.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:364369-364710:- | gene-YPL098C_NCIM3186 | rna-NM_001183912.1_NCIM3186 | cds-NP_015227.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:345883-346224:- | gene-YPL098C_NCYC1407 | rna-NM_001183912.1_NCYC1407 | cds-NP_015227.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:353373-353714:- | gene-YPL098C_PE2H3 | rna-NM_001183912.1_PE2H3 | cds-NP_015227.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:352996-353337:- | gene-YPL098C_PE2H4 | rna-NM_001183912.1_PE2H4 | cds-NP_015227.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:364386-364727:- | gene-YPL098C_S288C | rna-NM_001183912.1_S288C | cds-NP_015227.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:8952-9293:+ | gene-YPL098C_SA1 | rna-NM_001183912.1_SA1 | cds-NP_015227.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:348110-348451:- | gene-YPL098C_ThermosaccDry | rna-NM_001183912.1_ThermosaccDry | cds-NP_015227.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:363084-363425:- | gene-YPL098C_VR1 | rna-NM_001183912.1_VR1 | cds-NP_015227.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:347431-347772:- | gene-YPL098C_ZTW1 | rna-NM_001183912.1_ZTW1 | cds-NP_015227.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:349100-349441:- | gene-YPL098C_Sparadoxus | rna-NM_001183912.1_Sparadoxus | cds-NP_015227.1_Sparadoxus | 92.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |