Gene name: MGE1
Reference locus (S288C): YOR232W
Gene biotype: protein_coding
Description: GrpE protein homolog, mitochondrial; Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress; Belongs to the GrpE family
Top 10 interactors (score): PAM18 (0.999); SSC1 (0.999); MDJ1 (0.999); PAM16 (0.999); TIM44 (0.999); TIM17 (0.998); TIM50 (0.997); ECM10 (0.995); JAC1 (0.994); MDJ2 (0.993); SSQ1 (0.992); HSP10 (0.99); TIM21 (0.989); HSP60 (0.986); PAM17 (0.985); TIM23 (0.972); HNT2 (0.967); HSP104 (0.966); NIT2 (0.964); YPL225W (0.964)
Homologues (species, bitscore): GRPEL1 (Homo sapiens, 113.6); Grpel1 (Mus musculus, 113.6); grpel1 (Danio rerio, 114.8); grpel1 (Xenopus tropicalis, 122.9); Roe1 (Drosophila melanogaster, 150.6); C34C12.8 (Caenorhabditis elegans, 115.2); AR192 (Arabidopsis thaliana, 138.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:765345-766031:+ | gene-YOR232W_AKU4011 | rna-NM_001183651.3_AKU4011 | cds-NP_014875.3_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:167385-168071:+ | gene-YOR232W_BG1 | rna-NM_001183651.3_BG1 | cds-NP_014875.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:750812-751498:+ | gene-YOR232W_Bruggeman | rna-NM_001183651.3_Bruggeman | cds-NP_014875.3_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:751463-752149:+ | gene-YOR232W_CAT1 | rna-NM_001183651.3_CAT1 | cds-NP_014875.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:748334-749020:+ | gene-YOR232W_CBS1585 | rna-NM_001183651.3_CBS1585 | cds-NP_014875.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:747029-747715:+ | gene-YOR232W_CBS436 | rna-NM_001183651.3_CBS436 | cds-NP_014875.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:745453-746139:+ | gene-YOR232W_CBS6412 | rna-NM_001183651.3_CBS6412 | cds-NP_014875.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:754093-754779:+ | gene-YOR232W_CBS6413 | rna-NM_001183651.3_CBS6413 | cds-NP_014875.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:774335-775021:+ | gene-YOR232W_CENPK1137D | rna-NM_001183651.3_CENPK1137D | cds-NP_014875.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:741465-742151:+ | gene-YOR232W_EthanolRed | rna-NM_001183651.3_EthanolRed | cds-NP_014875.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:746864-747550:+ | gene-YOR232W_FaliES1 | rna-NM_001183651.3_FaliES1 | cds-NP_014875.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:79287-79973:- | gene-YOR232W_JAY291 | rna-NM_001183651.3_JAY291 | cds-NP_014875.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:754135-754821:+ | gene-YOR232W_MUCL30387 | rna-NM_001183651.3_MUCL30387 | cds-NP_014875.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:762201-762887:+ | gene-YOR232W_MUCL30388 | rna-NM_001183651.3_MUCL30388 | cds-NP_014875.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:755664-756350:+ | gene-YOR232W_MUCL39482 | rna-NM_001183651.3_MUCL39482 | cds-NP_014875.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:765253-765939:+ | gene-YOR232W_MUCL42920 | rna-NM_001183651.3_MUCL42920 | cds-NP_014875.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:774462-775148:+ | gene-YOR232W_NCIM3186 | rna-NM_001183651.3_NCIM3186 | cds-NP_014875.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:755763-756449:+ | gene-YOR232W_NCYC1407 | rna-NM_001183651.3_NCYC1407 | cds-NP_014875.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:755065-755751:+ | gene-YOR232W_PE2H3 | rna-NM_001183651.3_PE2H3 | cds-NP_014875.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:765442-766128:+ | gene-YOR232W_PE2H4 | rna-NM_001183651.3_PE2H4 | cds-NP_014875.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:774573-775259:+ | gene-YOR232W_S288C | rna-NM_001183651.3_S288C | cds-NP_014875.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:184566-185252:+ | gene-YOR232W_SA1 | rna-NM_001183651.3_SA1 | cds-NP_014875.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:746047-746733:+ | gene-YOR232W_ThermosaccDry | rna-NM_001183651.3_ThermosaccDry | cds-NP_014875.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:809505-810191:+ | gene-YOR232W_VR1 | rna-NM_001183651.3_VR1 | cds-NP_014875.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:478968-479654:+ | gene-YOR232W_ZTW1 | rna-NM_001183651.3_ZTW1 | cds-NP_014875.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:751921-752607:+ | gene-YOR232W_Sparadoxus | rna-NM_001183651.3_Sparadoxus | cds-NP_014875.3_Sparadoxus | 91.8 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |