Gene name: MET4
Reference locus (S288C): YNL103W
Gene biotype: protein_coding
Description: Leucine-zipper transcriptional activator; responsible for regulation of sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; can be ubiquitinated by ubiquitin ligase SCF-Met30p, is either degraded or maintained in an inactive state; regulates degradation of its own DNA-binding cofactors by targeting them to SCF-Met30p
Top 10 interactors (score): CBF1 (0.999); MET28 (0.999); MET30 (0.995); MET31 (0.993); MET32 (0.984); CDC34 (0.87); MET16 (0.84); SAM2 (0.797); MET17 (0.783); GSH1 (0.78); MET14 (0.78); GCN4 (0.78); MET3 (0.766); GAL4 (0.745); CDC53 (0.715); PHO4 (0.712); SFP1 (0.711); YAP1 (0.711); CYS3 (0.71); YHR112C (0.698)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:421396-423414:+ | gene-YNL103W_AKU4011 | rna-NM_001182941.3_AKU4011 | cds-NP_014296.4_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:325399-327418:+ | gene-YNL103W_BG1 | rna-NM_001182941.3_BG1 | cds-NP_014296.4_BG1 | 98.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:432113-434131:+ | gene-YNL103W_Bruggeman | rna-NM_001182941.3_Bruggeman | cds-NP_014296.4_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:475155-477173:+ | gene-YNL103W_CAT1 | rna-NM_001182941.3_CAT1 | cds-NP_014296.4_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:422003-424021:+ | gene-YNL103W_CBS1585 | rna-NM_001182941.3_CBS1585 | cds-NP_014296.4_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:490418-492436:+ | gene-YNL103W_CBS436 | rna-NM_001182941.3_CBS436 | cds-NP_014296.4_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:417476-419398:+ | gene-YNL103W_CBS6412 | rna-NM_001182941.3_CBS6412 | cds-NP_014296.4_CBS6412 | 89.9 | 94.4 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:418479-420497:+ | gene-YNL103W_CBS6413 | rna-NM_001182941.3_CBS6413 | cds-NP_014296.4_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:421586-423603:+ | gene-YNL103W_CENPK1137D | rna-NM_001182941.3_CENPK1137D | cds-NP_014296.4_CENPK1137D | 93.2 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:418405-420423:+ | gene-YNL103W_EthanolRed | rna-NM_001182941.3_EthanolRed | cds-NP_014296.4_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:414303-416321:+ | gene-YNL103W_FaliES1 | rna-NM_001182941.3_FaliES1 | cds-NP_014296.4_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000140.1:1935-3952:+ | gene-YNL103W_JAY291 | rna-NM_001182941.3_JAY291 | cds-NP_014296.4_JAY291 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:428283-430301:+ | gene-YNL103W_MUCL30387 | rna-NM_001182941.3_MUCL30387 | cds-NP_014296.4_MUCL30387 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:463675-465693:+ | gene-YNL103W_MUCL30388 | rna-NM_001182941.3_MUCL30388 | cds-NP_014296.4_MUCL30388 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:419396-421414:+ | gene-YNL103W_MUCL39482 | rna-NM_001182941.3_MUCL39482 | cds-NP_014296.4_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:423416-425434:+ | gene-YNL103W_MUCL42920 | rna-NM_001182941.3_MUCL42920 | cds-NP_014296.4_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:427704-429722:+ | gene-YNL103W_NCIM3186 | rna-NM_001182941.3_NCIM3186 | cds-NP_014296.4_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:421524-423542:+ | gene-YNL103W_NCYC1407 | rna-NM_001182941.3_NCYC1407 | cds-NP_014296.4_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:420445-422463:+ | gene-YNL103W_PE2H3 | rna-NM_001182941.3_PE2H3 | cds-NP_014296.4_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:419851-421869:+ | gene-YNL103W_PE2H4 | rna-NM_001182941.3_PE2H4 | cds-NP_014296.4_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:427735-429753:+ | gene-YNL103W_S288C | rna-NM_001182941.3_S288C | cds-NP_014296.4_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000024.1:12696-14714:+ | gene-YNL103W_SA1 | rna-NM_001182941.3_SA1 | cds-NP_014296.4_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:415177-417195:+ | gene-YNL103W_ThermosaccDry | rna-NM_001182941.3_ThermosaccDry | cds-NP_014296.4_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:433872-435891:+ | gene-YNL103W_VR1 | rna-NM_001182941.3_VR1 | cds-NP_014296.4_VR1 | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:324984-327002:+ | gene-YNL103W_ZTW1 | rna-NM_001182941.3_ZTW1 | cds-NP_014296.4_ZTW1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:426048-428087:+ | gene-YNL103W_Sparadoxus | rna-NM_001182941.3_Sparadoxus | cds-NP_014296.4_Sparadoxus | 85.3 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |