Gene name: MET18
Reference locus (S288C): YIL128W
Gene biotype: protein_coding
Description: DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; Belongs to the MET18/MMS19 family
Top 10 interactors (score): RAD3 (0.999); CIA1 (0.999); CIA2 (0.999); NBP35 (0.998); NAR1 (0.997); CFD1 (0.997); DNA2 (0.994); POL3 (0.993); TAH18 (0.992); DRE2 (0.99); RLI1 (0.97); PGK1 (0.964); POL2 (0.952); VMA6 (0.907); QCR9 (0.896); MET2 (0.896); RAD4 (0.884); ISD11 (0.884); PRI2 (0.874); ADE4 (0.862)
Homologues (species, bitscore): MMS19 (Homo sapiens, 205.7); Mms19 (Mus musculus, 213.0); mms19 (Danio rerio, 183.3); mms19 (Xenopus tropicalis, 246.1); Mms19 (Drosophila melanogaster, 124.4); mms-19 (Caenorhabditis elegans, 70.9); MET18 (Arabidopsis thaliana, 110.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:115026-118124:+ | gene-YIL128W_AKU4011 | rna-NM_001179476.1_AKU4011 | cds-NP_012138.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000174.1:19635-22733:- | gene-YIL128W_BG1 | rna-NM_001179476.1_BG1 | cds-NP_012138.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:117776-120874:+ | gene-YIL128W_Bruggeman | rna-NM_001179476.1_Bruggeman | cds-NP_012138.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:111656-114754:+ | gene-YIL128W_CAT1 | rna-NM_001179476.1_CAT1 | cds-NP_012138.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:115258-118356:+ | gene-YIL128W_CBS1585 | rna-NM_001179476.1_CBS1585 | cds-NP_012138.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:106395-109493:+ | gene-YIL128W_CBS436 | rna-NM_001179476.1_CBS436 | cds-NP_012138.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:112745-115843:+ | gene-YIL128W_CBS6412 | rna-NM_001179476.1_CBS6412 | cds-NP_012138.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:106505-109603:+ | gene-YIL128W_CBS6413 | rna-NM_001179476.1_CBS6413 | cds-NP_012138.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:105516-108614:+ | gene-YIL128W_CENPK1137D | rna-NM_001179476.1_CENPK1137D | cds-NP_012138.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:100310-103408:+ | gene-YIL128W_EthanolRed | rna-NM_001179476.1_EthanolRed | cds-NP_012138.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:116361-119459:+ | gene-YIL128W_FaliES1 | rna-NM_001179476.1_FaliES1 | cds-NP_012138.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000383.1:29874-32972:- | gene-YIL128W_JAY291 | rna-NM_001179476.1_JAY291 | cds-NP_012138.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:115631-118729:+ | gene-YIL128W_MUCL30387 | rna-NM_001179476.1_MUCL30387 | cds-NP_012138.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:115215-118313:+ | gene-YIL128W_MUCL30388 | rna-NM_001179476.1_MUCL30388 | cds-NP_012138.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:116203-119301:+ | gene-YIL128W_MUCL39482 | rna-NM_001179476.1_MUCL39482 | cds-NP_012138.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:119389-122487:+ | gene-YIL128W_MUCL42920 | rna-NM_001179476.1_MUCL42920 | cds-NP_012138.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:113806-116904:+ | gene-YIL128W_NCIM3186 | rna-NM_001179476.1_NCIM3186 | cds-NP_012138.1_NCIM3186 | 97.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:120189-123287:+ | gene-YIL128W_NCYC1407 | rna-NM_001179476.1_NCYC1407 | cds-NP_012138.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:114869-117967:+ | gene-YIL128W_PE2H3 | rna-NM_001179476.1_PE2H3 | cds-NP_012138.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:108844-111942:+ | gene-YIL128W_PE2H4 | rna-NM_001179476.1_PE2H4 | cds-NP_012138.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:113806-116904:+ | gene-YIL128W_S288C | rna-NM_001179476.1_S288C | cds-NP_012138.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000058.1:66353-69451:- | gene-YIL128W_SA1 | rna-NM_001179476.1_SA1 | cds-NP_012138.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:115018-118116:+ | gene-YIL128W_ThermosaccDry | rna-NM_001179476.1_ThermosaccDry | cds-NP_012138.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:112178-115276:+ | gene-YIL128W_VR1 | rna-NM_001179476.1_VR1 | cds-NP_012138.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:89954-93052:+ | gene-YIL128W_ZTW1 | rna-NM_001179476.1_ZTW1 | cds-NP_012138.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:107769-110864:+ | gene-YIL128W_Sparadoxus | rna-NM_001179476.1_Sparadoxus | cds-NP_012138.1_Sparadoxus | 88.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |