Gene name: MET12
Reference locus (S288C): YPL023C
Gene biotype: protein_coding
Description: Methylenetetrahydrofolate reductase 1; Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)
Top 10 interactors (score): MET13 (0.987); SHM1 (0.982); GCV1 (0.978); GCV2 (0.976); MIS1 (0.975); GCV3 (0.97); MTD1 (0.969); CDC21 (0.966); ADE3 (0.957); SHM2 (0.957); LPD1 (0.924); MET6 (0.882); MET7 (0.88); RMA1 (0.866); FOL3 (0.841); FOL2 (0.797); STR3 (0.791); ARG5,6 (0.775); CYS3 (0.769); SAH1 (0.758)
Homologues (species, bitscore): MTHFR (Homo sapiens, 348.2); Mthfr (Mus musculus, 347.1); mthfr (Danio rerio, 346.3); mthfr (Xenopus tropicalis, 314.3); CG7560 (Drosophila melanogaster, 69.3); mthf-1 (Caenorhabditis elegans, 317.0); MTHFR2 (Arabidopsis thaliana, 361.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:475829-477802:- | gene-YPL023C_AKU4011 | rna-NM_001183837.1_AKU4011 | cds-NP_015302.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:419544-421517:+ | gene-YPL023C_BG1 | rna-NM_001183837.1_BG1 | cds-NP_015302.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:552778-554751:- | gene-YPL023C_Bruggeman | rna-NM_001183837.1_Bruggeman | cds-NP_015302.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:592442-594415:- | gene-YPL023C_CAT1 | rna-NM_001183837.1_CAT1 | cds-NP_015302.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:479899-481872:- | gene-YPL023C_CBS1585 | rna-NM_001183837.1_CBS1585 | cds-NP_015302.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:494028-496001:- | gene-YPL023C_CBS436 | rna-NM_001183837.1_CBS436 | cds-NP_015302.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:484092-486065:- | gene-YPL023C_CBS6412 | rna-NM_001183837.1_CBS6412 | cds-NP_015302.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:476452-478425:- | gene-YPL023C_CBS6413 | rna-NM_001183837.1_CBS6413 | cds-NP_015302.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:504314-506287:- | gene-YPL023C_CENPK1137D | rna-NM_001183837.1_CENPK1137D | cds-NP_015302.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:474192-476165:- | gene-YPL023C_EthanolRed | rna-NM_001183837.1_EthanolRed | cds-NP_015302.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:482022-483995:- | gene-YPL023C_FaliES1 | rna-NM_001183837.1_FaliES1 | cds-NP_015302.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000283.1:90625-92598:- | gene-YPL023C_JAY291 | rna-NM_001183837.1_JAY291 | cds-NP_015302.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:493726-495699:- | gene-YPL023C_MUCL30387 | rna-NM_001183837.1_MUCL30387 | cds-NP_015302.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:492834-494807:- | gene-YPL023C_MUCL30388 | rna-NM_001183837.1_MUCL30388 | cds-NP_015302.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:473216-475189:- | gene-YPL023C_MUCL39482 | rna-NM_001183837.1_MUCL39482 | cds-NP_015302.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:532346-534319:- | gene-YPL023C_MUCL42920 | rna-NM_001183837.1_MUCL42920 | cds-NP_015302.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:504322-506295:- | gene-YPL023C_NCIM3186 | rna-NM_001183837.1_NCIM3186 | cds-NP_015302.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:480495-482468:- | gene-YPL023C_NCYC1407 | rna-NM_001183837.1_NCYC1407 | cds-NP_015302.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:487152-489125:- | gene-YPL023C_PE2H3 | rna-NM_001183837.1_PE2H3 | cds-NP_015302.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:486767-488740:- | gene-YPL023C_PE2H4 | rna-NM_001183837.1_PE2H4 | cds-NP_015302.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:504339-506312:- | gene-YPL023C_S288C | rna-NM_001183837.1_S288C | cds-NP_015302.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000076.1:1017-2990:- | gene-YPL023C_SA1 | rna-NM_001183837.1_SA1 | cds-NP_015302.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:481821-483794:- | gene-YPL023C_ThermosaccDry | rna-NM_001183837.1_ThermosaccDry | cds-NP_015302.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:496709-498682:- | gene-YPL023C_VR1 | rna-NM_001183837.1_VR1 | cds-NP_015302.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:481111-483084:- | gene-YPL023C_ZTW1 | rna-NM_001183837.1_ZTW1 | cds-NP_015302.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:481042-483015:- | gene-YPL023C_Sparadoxus | rna-NM_001183837.1_Sparadoxus | cds-NP_015302.1_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |