Gene name: MED6
Reference locus (S288C): YHR058C
Gene biotype: protein_coding
Description: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): SSN8 (0.999); SOH1 (0.999); SRB7 (0.999); RGR1 (0.999); SRB4 (0.999); MED7 (0.999); MED8 (0.999); MED11 (0.999); SSN2 (0.999); NUT2 (0.999); SRB5 (0.999); ROX3 (0.998); SRB6 (0.998); SSN3 (0.998); CSE2 (0.997); SRB2 (0.997); MED4 (0.997); RPB8 (0.996); GAL11 (0.994); RPO21 (0.994)
Homologues (species, bitscore): MED6 (Homo sapiens, 84.3); Med6 (Mus musculus, 84.0); med6 (Danio rerio, 81.6); med6 (Xenopus tropicalis, 84.7); MED6 (Drosophila melanogaster, 77.0); mdt-6 (Caenorhabditis elegans, 56.6); MED6 (Arabidopsis thaliana, 68.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:205256-206143:- | gene-YHR058C_AKU4011 | rna-NM_001179188.1_AKU4011 | cds-NP_011925.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:126396-127283:- | gene-YHR058C_BG1 | rna-NM_001179188.1_BG1 | cds-NP_011925.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:213014-213901:- | gene-YHR058C_Bruggeman | rna-NM_001179188.1_Bruggeman | cds-NP_011925.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:207802-208689:- | gene-YHR058C_CAT1 | rna-NM_001179188.1_CAT1 | cds-NP_011925.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:204362-205249:- | gene-YHR058C_CBS1585 | rna-NM_001179188.1_CBS1585 | cds-NP_011925.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:202319-203206:- | gene-YHR058C_CBS436 | rna-NM_001179188.1_CBS436 | cds-NP_011925.1_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:204594-205481:- | gene-YHR058C_CBS6412 | rna-NM_001179188.1_CBS6412 | cds-NP_011925.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:205426-206313:- | gene-YHR058C_CBS6413 | rna-NM_001179188.1_CBS6413 | cds-NP_011925.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:212160-213047:- | gene-YHR058C_CENPK1137D | rna-NM_001179188.1_CENPK1137D | cds-NP_011925.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:204753-205640:- | gene-YHR058C_EthanolRed | rna-NM_001179188.1_EthanolRed | cds-NP_011925.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:205730-206617:- | gene-YHR058C_FaliES1 | rna-NM_001179188.1_FaliES1 | cds-NP_011925.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000280.1:10691-11578:+ | gene-YHR058C_JAY291 | rna-NM_001179188.1_JAY291 | cds-NP_011925.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:212469-213356:- | gene-YHR058C_MUCL30387 | rna-NM_001179188.1_MUCL30387 | cds-NP_011925.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:212648-213535:- | gene-YHR058C_MUCL30388 | rna-NM_001179188.1_MUCL30388 | cds-NP_011925.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:204647-205534:- | gene-YHR058C_MUCL39482 | rna-NM_001179188.1_MUCL39482 | cds-NP_011925.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:211553-212440:- | gene-YHR058C_MUCL42920 | rna-NM_001179188.1_MUCL42920 | cds-NP_011925.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:218879-219766:- | gene-YHR058C_NCIM3186 | rna-NM_001179188.1_NCIM3186 | cds-NP_011925.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:676288-677175:- | gene-YHR058C_NCYC1407 | rna-NM_001179188.1_NCYC1407 | cds-NP_011925.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:206850-207737:- | gene-YHR058C_PE2H3 | rna-NM_001179188.1_PE2H3 | cds-NP_011925.1_PE2H3 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:214297-215184:- | gene-YHR058C_PE2H4 | rna-NM_001179188.1_PE2H4 | cds-NP_011925.1_PE2H4 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:218997-219884:- | gene-YHR058C_S288C | rna-NM_001179188.1_S288C | cds-NP_011925.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:139557-140444:+ | gene-YHR058C_SA1 | rna-NM_001179188.1_SA1 | cds-NP_011925.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:206821-207708:- | gene-YHR058C_ThermosaccDry | rna-NM_001179188.1_ThermosaccDry | cds-NP_011925.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:214460-215347:- | gene-YHR058C_VR1 | rna-NM_001179188.1_VR1 | cds-NP_011925.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:198374-199261:- | gene-YHR058C_ZTW1 | rna-NM_001179188.1_ZTW1 | cds-NP_011925.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:203913-204800:- | gene-YHR058C_Sparadoxus | rna-NM_001179188.1_Sparadoxus | cds-NP_011925.1_Sparadoxus | 89.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |