Gene name: MEC1
Reference locus (S288C): YBR136W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase MEC1; Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres; Belongs to the PI3/PI4-kinase family. ATM subfamily
Top 10 interactors (score): MRC1 (0.999); RAD9 (0.999); DUN1 (0.999); RAD24 (0.999); RFA1 (0.999); TEL1 (0.999); RAD17 (0.999); SGS1 (0.999); RAD53 (0.999); DPB11 (0.999); CHK1 (0.999); LCD1 (0.999); RFA2 (0.998); RAD52 (0.998); RAD51 (0.997); DNA2 (0.994); EXO1 (0.994); DDC1 (0.993); SML1 (0.993); MRE11 (0.992)
Homologues (species, bitscore): ATR (Homo sapiens, 411.0); Atr (Mus musculus, 415.2); atr (Danio rerio, 361.7); atr (Xenopus tropicalis, 402.9); mei-41 (Drosophila melanogaster, 327.4); let-363 (Caenorhabditis elegans, 194.5); ATR (Arabidopsis thaliana, 389.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:488554-495660:+ | gene-YBR136W_AKU4011 | rna-NM_001178484.3_AKU4011 | cds-NP_009694.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:479123-486229:+ | gene-YBR136W_BG1 | rna-NM_001178484.3_BG1 | cds-NP_009694.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:490359-497465:+ | gene-YBR136W_Bruggeman | rna-NM_001178484.3_Bruggeman | cds-NP_009694.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:385699-392805:+ | gene-YBR136W_CAT1 | rna-NM_001178484.3_CAT1 | cds-NP_009694.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:480334-487440:+ | gene-YBR136W_CBS1585 | rna-NM_001178484.3_CBS1585 | cds-NP_009694.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:488446-495552:+ | gene-YBR136W_CBS436 | rna-NM_001178484.3_CBS436 | cds-NP_009694.3_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:578200-585306:+ | gene-YBR136W_CBS6412 | rna-NM_001178484.3_CBS6412 | cds-NP_009694.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:485969-493075:+ | gene-YBR136W_CBS6413 | rna-NM_001178484.3_CBS6413 | cds-NP_009694.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:499438-506544:+ | gene-YBR136W_CENPK1137D | rna-NM_001178484.3_CENPK1137D | cds-NP_009694.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:614576-621682:+ | gene-YBR136W_EthanolRed | rna-NM_001178484.3_EthanolRed | cds-NP_009694.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:504588-511694:+ | gene-YBR136W_FaliES1 | rna-NM_001178484.3_FaliES1 | cds-NP_009694.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000444.1:28046-35152:+ | gene-YBR136W_JAY291 | rna-NM_001178484.3_JAY291 | cds-NP_009694.3_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:493233-500339:+ | gene-YBR136W_MUCL30387 | rna-NM_001178484.3_MUCL30387 | cds-NP_009694.3_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:492523-499629:+ | gene-YBR136W_MUCL30388 | rna-NM_001178484.3_MUCL30388 | cds-NP_009694.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:478721-485827:+ | gene-YBR136W_MUCL39482 | rna-NM_001178484.3_MUCL39482 | cds-NP_009694.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:488625-495731:+ | gene-YBR136W_MUCL42920 | rna-NM_001178484.3_MUCL42920 | cds-NP_009694.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:505465-512571:+ | gene-YBR136W_NCIM3186 | rna-NM_001178484.3_NCIM3186 | cds-NP_009694.3_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:481260-488366:+ | gene-YBR136W_NCYC1407 | rna-NM_001178484.3_NCYC1407 | cds-NP_009694.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:493892-500998:+ | gene-YBR136W_PE2H3 | rna-NM_001178484.3_PE2H3 | cds-NP_009694.3_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:491568-498674:+ | gene-YBR136W_PE2H4 | rna-NM_001178484.3_PE2H4 | cds-NP_009694.3_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:505668-512774:+ | gene-YBR136W_S288C | rna-NM_001178484.3_S288C | cds-NP_009694.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:26849-33955:+ | gene-YBR136W_SA1 | rna-NM_001178484.3_SA1 | cds-NP_009694.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:503601-510707:+ | gene-YBR136W_ThermosaccDry | rna-NM_001178484.3_ThermosaccDry | cds-NP_009694.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:485098-492204:+ | gene-YBR136W_VR1 | rna-NM_001178484.3_VR1 | cds-NP_009694.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:478746-485852:+ | gene-YBR136W_ZTW1 | rna-NM_001178484.3_ZTW1 | cds-NP_009694.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:515963-523069:+ | gene-YBR136W_Sparadoxus | rna-NM_001178484.3_Sparadoxus | cds-NP_009694.3_Sparadoxus | 90.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |