Gene name: MDM1
Reference locus (S288C): YML104C
Gene biotype: protein_coding
Description: Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease
Top 10 interactors (score): RAX1 (0.949); MMM1 (0.923); RGS2 (0.902); MDM10 (0.867); GPA2 (0.865); NVJ3 (0.817); SNX3 (0.804); FAA1 (0.803); VPS60 (0.787); SST2 (0.767); NVJ1 (0.745); YGL024W (0.711); VPS52 (0.697); RER1 (0.685); NVJ2 (0.671); VPS34 (0.668); VPS5 (0.663); YPT35 (0.65); YKR078W (0.648); MRPL3 (0.633)
Homologues (species, bitscore): SNX25 (Homo sapiens, 57.0); Snx25 (Mus musculus, 50.8); snx25 (Danio rerio, 52.8); snx13 (Xenopus tropicalis, 54.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:52663-56046:- | gene-YML104C_AKU4011 | rna-NM_001182466.1_AKU4011 | cds-NP_013603.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:420080-423463:+ | gene-YML104C_BG1 | rna-NM_001182466.1_BG1 | cds-NP_013603.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:58919-62302:- | gene-YML104C_Bruggeman | rna-NM_001182466.1_Bruggeman | cds-NP_013603.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:60472-63855:- | gene-YML104C_CAT1 | rna-NM_001182466.1_CAT1 | cds-NP_013603.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:52664-56047:- | gene-YML104C_CBS1585 | rna-NM_001182466.1_CBS1585 | cds-NP_013603.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:58657-62040:- | gene-YML104C_CBS436 | rna-NM_001182466.1_CBS436 | cds-NP_013603.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:53427-56810:- | gene-YML104C_CBS6412 | rna-NM_001182466.1_CBS6412 | cds-NP_013603.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:51891-55274:- | gene-YML104C_CBS6413 | rna-NM_001182466.1_CBS6413 | cds-NP_013603.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:53536-56919:- | gene-YML104C_CENPK1137D | rna-NM_001182466.1_CENPK1137D | cds-NP_013603.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:53172-56555:- | gene-YML104C_EthanolRed | rna-NM_001182466.1_EthanolRed | cds-NP_013603.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:53449-56832:- | gene-YML104C_FaliES1 | rna-NM_001182466.1_FaliES1 | cds-NP_013603.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000345.1:33351-36734:+ | gene-YML104C_JAY291 | rna-NM_001182466.1_JAY291 | cds-NP_013603.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:57370-60753:- | gene-YML104C_MUCL30387 | rna-NM_001182466.1_MUCL30387 | cds-NP_013603.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:60589-63972:- | gene-YML104C_MUCL30388 | rna-NM_001182466.1_MUCL30388 | cds-NP_013603.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:52678-56061:- | gene-YML104C_MUCL39482 | rna-NM_001182466.1_MUCL39482 | cds-NP_013603.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:56835-60218:- | gene-YML104C_MUCL42920 | rna-NM_001182466.1_MUCL42920 | cds-NP_013603.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:58893-62276:- | gene-YML104C_NCIM3186 | rna-NM_001182466.1_NCIM3186 | cds-NP_013603.1_NCIM3186 | 96.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:53472-56855:- | gene-YML104C_NCYC1407 | rna-NM_001182466.1_NCYC1407 | cds-NP_013603.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:58908-62291:- | gene-YML104C_PE2H3 | rna-NM_001182466.1_PE2H3 | cds-NP_013603.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:58846-62229:- | gene-YML104C_PE2H4 | rna-NM_001182466.1_PE2H4 | cds-NP_013603.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:58939-62322:- | gene-YML104C_S288C | rna-NM_001182466.1_S288C | cds-NP_013603.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000054.1:50912-54295:- | gene-YML104C_SA1 | rna-NM_001182466.1_SA1 | cds-NP_013603.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:52746-56129:- | gene-YML104C_ThermosaccDry | rna-NM_001182466.1_ThermosaccDry | cds-NP_013603.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:57127-60510:- | gene-YML104C_VR1 | rna-NM_001182466.1_VR1 | cds-NP_013603.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:32231-35614:- | gene-YML104C_ZTW1 | rna-NM_001182466.1_ZTW1 | cds-NP_013603.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:63596-66988:- | gene-YML104C_Sparadoxus | rna-NM_001182466.1_Sparadoxus | cds-NP_013603.1_Sparadoxus | 87.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |