Gene name: MDL2
Reference locus (S288C): YPL270W
Gene biotype: protein_coding
Description: ATP-dependent permease MDL2, mitochondrial; Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily
Top 10 interactors (score): MRPL11 (0.708); MHP1 (0.693); HEM15 (0.668); HEM14 (0.654); YMC1 (0.634); PXA2 (0.624); AFG3 (0.623); OXR1 (0.62); LSC2 (0.618); FMT1 (0.616); HEM1 (0.615); GEP3 (0.614); RLI1 (0.6); HEM12 (0.589); MMT2 (0.581); SWS2 (0.571); HEM2 (0.571); HEM4 (0.556); YJR085C (0.549); MRPL23 (0.53)
Homologues (species, bitscore): ABCB10 (Homo sapiens, 438.0); Abcb10 (Mus musculus, 423.3); abcb10 (Danio rerio, 436.4); abcb10 (Xenopus tropicalis, 360.5); CG3156 (Drosophila melanogaster, 395.2); haf-3 (Caenorhabditis elegans, 391.3); ABCB27 (Arabidopsis thaliana, 372.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:14785-17106:+ | gene-YPL270W_AKU4011 | rna-NM_001184084.1_AKU4011 | cds-NP_015053.2_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000185.1:23682-26091:- | gene-YPL270W_BG1 | rna-NM_001184084.1_BG1 | cds-NP_015053.2_BG1 | 95.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:31772-34093:+ | gene-YPL270W_Bruggeman | rna-NM_001184084.1_Bruggeman | cds-NP_015053.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:29991-32312:+ | gene-YPL270W_CAT1 | rna-NM_001184084.1_CAT1 | cds-NP_015053.2_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:18493-20814:+ | gene-YPL270W_CBS1585 | rna-NM_001184084.1_CBS1585 | cds-NP_015053.2_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:26886-29207:+ | gene-YPL270W_CBS436 | rna-NM_001184084.1_CBS436 | cds-NP_015053.2_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:23397-25718:+ | gene-YPL270W_CBS6412 | rna-NM_001184084.1_CBS6412 | cds-NP_015053.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:14645-16966:+ | gene-YPL270W_CBS6413 | rna-NM_001184084.1_CBS6413 | cds-NP_015053.2_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:30427-32748:+ | gene-YPL270W_CENPK1137D | rna-NM_001184084.1_CENPK1137D | cds-NP_015053.2_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:13815-16136:+ | gene-YPL270W_EthanolRed | rna-NM_001184084.1_EthanolRed | cds-NP_015053.2_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:14163-16484:+ | gene-YPL270W_FaliES1 | rna-NM_001184084.1_FaliES1 | cds-NP_015053.2_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000190.1:23595-25916:- | gene-YPL270W_JAY291 | rna-NM_001184084.1_JAY291 | cds-NP_015053.2_JAY291 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:31298-33619:+ | gene-YPL270W_MUCL30387 | rna-NM_001184084.1_MUCL30387 | cds-NP_015053.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:29487-31808:+ | gene-YPL270W_MUCL30388 | rna-NM_001184084.1_MUCL30388 | cds-NP_015053.2_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:11623-13944:+ | gene-YPL270W_MUCL39482 | rna-NM_001184084.1_MUCL39482 | cds-NP_015053.2_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:23783-26104:+ | gene-YPL270W_MUCL42920 | rna-NM_001184084.1_MUCL42920 | cds-NP_015053.2_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:30465-32786:+ | gene-YPL270W_NCIM3186 | rna-NM_001184084.1_NCIM3186 | cds-NP_015053.2_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:18069-20390:+ | gene-YPL270W_NCYC1407 | rna-NM_001184084.1_NCYC1407 | cds-NP_015053.2_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:21718-24039:+ | gene-YPL270W_PE2H3 | rna-NM_001184084.1_PE2H3 | cds-NP_015053.2_PE2H3 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:21695-24016:+ | gene-YPL270W_PE2H4 | rna-NM_001184084.1_PE2H4 | cds-NP_015053.2_PE2H4 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:30482-32803:+ | gene-YPL270W_S288C | rna-NM_001184084.1_S288C | cds-NP_015053.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000104.1:23720-26041:- | gene-YPL270W_SA1 | rna-NM_001184084.1_SA1 | cds-NP_015053.2_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:14164-16485:+ | gene-YPL270W_ThermosaccDry | rna-NM_001184084.1_ThermosaccDry | cds-NP_015053.2_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:260576-262897:+ | gene-YPL270W_VR1 | rna-NM_001184084.1_VR1 | cds-NP_015053.2_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:20285-22606:+ | gene-YPL270W_ZTW1 | rna-NM_001184084.1_ZTW1 | cds-NP_015053.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:22222-24543:+ | gene-YPL270W_Sparadoxus | rna-NM_001184084.1_Sparadoxus | cds-NP_015053.2_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |