Gene name: MDH2
Reference locus (S288C): YOL126C
Gene biotype: protein_coding
Description: Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
Top 10 interactors (score): FUM1 (0.995); MLS1 (0.994); CIT2 (0.993); PCK1 (0.992); MAE1 (0.992); CIT1 (0.99); CIT3 (0.987); AAT1 (0.982); PYC2 (0.979); LSC1 (0.969); FBP1 (0.962); AAT2 (0.961); DAL7 (0.961); PYC1 (0.961); ICL1 (0.943); ATP3 (0.94); MDH1 (0.927); GDH2 (0.915); CYT1 (0.909); ACO1 (0.908)
Homologues (species, bitscore): MDH2 (Homo sapiens, 221.9); Mdh2 (Mus musculus, 220.7); mdh2 (Danio rerio, 210.7); mdh2 (Xenopus tropicalis, 217.2); Mdh2 (Drosophila melanogaster, 224.2); mdh-2 (Caenorhabditis elegans, 214.5); PMDH2 (Arabidopsis thaliana, 208.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:70440-71573:- | gene-YOL126C_AKU4011 | rna-NM_001183380.1_AKU4011 | cds-NP_014515.2_AKU4011 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:36066-37199:- | gene-YOL126C_BG1 | rna-NM_001183380.1_BG1 | cds-NP_014515.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:71715-72848:- | gene-YOL126C_Bruggeman | rna-NM_001183380.1_Bruggeman | cds-NP_014515.2_Bruggeman | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:70677-71810:- | gene-YOL126C_CAT1 | rna-NM_001183380.1_CAT1 | cds-NP_014515.2_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:64918-66051:- | gene-YOL126C_CBS1585 | rna-NM_001183380.1_CBS1585 | cds-NP_014515.2_CBS1585 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:70770-71903:- | gene-YOL126C_CBS436 | rna-NM_001183380.1_CBS436 | cds-NP_014515.2_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:64780-65913:- | gene-YOL126C_CBS6412 | rna-NM_001183380.1_CBS6412 | cds-NP_014515.2_CBS6412 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:71248-72381:- | gene-YOL126C_CBS6413 | rna-NM_001183380.1_CBS6413 | cds-NP_014515.2_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:81684-82817:- | gene-YOL126C_CENPK1137D | rna-NM_001183380.1_CENPK1137D | cds-NP_014515.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:68690-69823:- | gene-YOL126C_EthanolRed | rna-NM_001183380.1_EthanolRed | cds-NP_014515.2_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:70719-71852:- | gene-YOL126C_FaliES1 | rna-NM_001183380.1_FaliES1 | cds-NP_014515.2_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000329.1:10693-11826:+ | gene-YOL126C_JAY291 | rna-NM_001183380.1_JAY291 | cds-NP_014515.2_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:76356-77489:- | gene-YOL126C_MUCL30387 | rna-NM_001183380.1_MUCL30387 | cds-NP_014515.2_MUCL30387 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:79355-80488:- | gene-YOL126C_MUCL30388 | rna-NM_001183380.1_MUCL30388 | cds-NP_014515.2_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:72855-73988:- | gene-YOL126C_MUCL39482 | rna-NM_001183380.1_MUCL39482 | cds-NP_014515.2_MUCL39482 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:88734-89867:- | gene-YOL126C_MUCL42920 | rna-NM_001183380.1_MUCL42920 | cds-NP_014515.2_MUCL42920 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:81676-82809:- | gene-YOL126C_NCIM3186 | rna-NM_001183380.1_NCIM3186 | cds-NP_014515.2_NCIM3186 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:78890-80023:- | gene-YOL126C_NCYC1407 | rna-NM_001183380.1_NCYC1407 | cds-NP_014515.2_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:57325-58458:- | gene-YOL126C_PE2H3 | rna-NM_001183380.1_PE2H3 | cds-NP_014515.2_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:74273-75406:- | gene-YOL126C_PE2H4 | rna-NM_001183380.1_PE2H4 | cds-NP_014515.2_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:81787-82920:- | gene-YOL126C_S288C | rna-NM_001183380.1_S288C | cds-NP_014515.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:55215-56348:- | gene-YOL126C_SA1 | rna-NM_001183380.1_SA1 | cds-NP_014515.2_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:69857-70990:- | gene-YOL126C_ThermosaccDry | rna-NM_001183380.1_ThermosaccDry | cds-NP_014515.2_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:70521-71654:- | gene-YOL126C_VR1 | rna-NM_001183380.1_VR1 | cds-NP_014515.2_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:69610-70743:- | gene-YOL126C_ZTW1 | rna-NM_001183380.1_ZTW1 | cds-NP_014515.2_ZTW1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:72361-73494:- | gene-YOL126C_Sparadoxus | rna-NM_001183380.1_Sparadoxus | cds-NP_014515.2_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |