Gene name: MCM4
Reference locus (S288C): YPR019W
Gene biotype: protein_coding
Description: DNA replication licensing factor MCM4; Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
Top 10 interactors (score): MCM6 (0.999); PSF2 (0.999); POL1 (0.999); ORC3 (0.999); DPB2 (0.999); PSF3 (0.999); MCM2 (0.999); CDC45 (0.999); MCM7 (0.999); POL2 (0.999); MCM3 (0.999); MCM5 (0.999); PSF1 (0.999); TOF1 (0.999); CHK1 (0.999); CTF4 (0.999); CDC7 (0.999); MCM10 (0.999); TAH11 (0.999); CSM3 (0.999)
Homologues (species, bitscore): MCM4 (Homo sapiens, 681.8); Mcm4 (Mus musculus, 682.9); mcm4 (Danio rerio, 679.1); mcm4 (Xenopus tropicalis, 617.8); dpa (Drosophila melanogaster, 663.7); mcm-4 (Caenorhabditis elegans, 607.4); MCM4 (Arabidopsis thaliana, 682.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:568405-571206:+ | gene-YPR019W_AKU4011 | rna-NM_001184116.1_AKU4011 | cds-NP_015344.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:325925-328726:- | gene-YPR019W_BG1 | rna-NM_001184116.1_BG1 | cds-NP_015344.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:646069-648870:+ | gene-YPR019W_Bruggeman | rna-NM_001184116.1_Bruggeman | cds-NP_015344.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:689567-692368:+ | gene-YPR019W_CAT1 | rna-NM_001184116.1_CAT1 | cds-NP_015344.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:572091-574892:+ | gene-YPR019W_CBS1585 | rna-NM_001184116.1_CBS1585 | cds-NP_015344.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:586464-589265:+ | gene-YPR019W_CBS436 | rna-NM_001184116.1_CBS436 | cds-NP_015344.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:575840-578641:+ | gene-YPR019W_CBS6412 | rna-NM_001184116.1_CBS6412 | cds-NP_015344.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:568554-571355:+ | gene-YPR019W_CBS6413 | rna-NM_001184116.1_CBS6413 | cds-NP_015344.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:596723-599524:+ | gene-YPR019W_CENPK1137D | rna-NM_001184116.1_CENPK1137D | cds-NP_015344.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:566340-569141:+ | gene-YPR019W_EthanolRed | rna-NM_001184116.1_EthanolRed | cds-NP_015344.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:574142-576943:+ | gene-YPR019W_FaliES1 | rna-NM_001184116.1_FaliES1 | cds-NP_015344.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000116.1:50494-53295:- | gene-YPR019W_JAY291 | rna-NM_001184116.1_JAY291 | cds-NP_015344.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:587289-590090:+ | gene-YPR019W_MUCL30387 | rna-NM_001184116.1_MUCL30387 | cds-NP_015344.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:585942-588743:+ | gene-YPR019W_MUCL30388 | rna-NM_001184116.1_MUCL30388 | cds-NP_015344.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:565332-568133:+ | gene-YPR019W_MUCL39482 | rna-NM_001184116.1_MUCL39482 | cds-NP_015344.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:626666-629467:+ | gene-YPR019W_MUCL42920 | rna-NM_001184116.1_MUCL42920 | cds-NP_015344.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:596733-599534:+ | gene-YPR019W_NCIM3186 | rna-NM_001184116.1_NCIM3186 | cds-NP_015344.1_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:573279-576080:+ | gene-YPR019W_NCYC1407 | rna-NM_001184116.1_NCYC1407 | cds-NP_015344.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:580012-582813:+ | gene-YPR019W_PE2H3 | rna-NM_001184116.1_PE2H3 | cds-NP_015344.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:579627-582428:+ | gene-YPR019W_PE2H4 | rna-NM_001184116.1_PE2H4 | cds-NP_015344.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:596750-599551:+ | gene-YPR019W_S288C | rna-NM_001184116.1_S288C | cds-NP_015344.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000026.1:100756-103557:- | gene-YPR019W_SA1 | rna-NM_001184116.1_SA1 | cds-NP_015344.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:573944-576745:+ | gene-YPR019W_ThermosaccDry | rna-NM_001184116.1_ThermosaccDry | cds-NP_015344.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:590183-592984:+ | gene-YPR019W_VR1 | rna-NM_001184116.1_VR1 | cds-NP_015344.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:573249-576050:+ | gene-YPR019W_ZTW1 | rna-NM_001184116.1_ZTW1 | cds-NP_015344.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:573431-576232:+ | gene-YPR019W_Sparadoxus | rna-NM_001184116.1_Sparadoxus | cds-NP_015344.1_Sparadoxus | 92.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |