Gene name: MCK1
Reference locus (S288C): YNL307C
Gene biotype: protein_coding
Description: Protein kinase MCK1; Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication
Top 10 interactors (score): NAT5 (0.838); ROG1 (0.837); CLB2 (0.831); RIM11 (0.813); MSN2 (0.794); CDC6 (0.77); CBF5 (0.757); HRR25 (0.754); PSR2 (0.746); BCY1 (0.745); URK1 (0.739); DAS2 (0.739); FUR1 (0.739); RGS2 (0.736); SST2 (0.736); CLB5 (0.732); BMH1 (0.728); MIH1 (0.727); ECO1 (0.694); SKN7 (0.69)
Homologues (species, bitscore): GSK3A (Homo sapiens, 271.6); Gsk3a (Mus musculus, 268.1); gsk3aa (Danio rerio, 272.7); gsk3a (Xenopus tropicalis, 268.5); gskt (Drosophila melanogaster, 269.6); gsk-3 (Caenorhabditis elegans, 269.2); At5g14640 (Arabidopsis thaliana, 261.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:50244-51371:- | gene-YNL307C_AKU4011 | rna-NM_001183145.1_AKU4011 | cds-NP_014092.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:39270-40397:+ | gene-YNL307C_BG1 | rna-NM_001183145.1_BG1 | cds-NP_014092.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:59583-60710:- | gene-YNL307C_Bruggeman | rna-NM_001183145.1_Bruggeman | cds-NP_014092.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:62198-63325:- | gene-YNL307C_CAT1 | rna-NM_001183145.1_CAT1 | cds-NP_014092.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:50576-51703:- | gene-YNL307C_CBS1585 | rna-NM_001183145.1_CBS1585 | cds-NP_014092.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:51068-52195:- | gene-YNL307C_CBS436 | rna-NM_001183145.1_CBS436 | cds-NP_014092.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:47235-48362:- | gene-YNL307C_CBS6412 | rna-NM_001183145.1_CBS6412 | cds-NP_014092.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:47424-48551:- | gene-YNL307C_CBS6413 | rna-NM_001183145.1_CBS6413 | cds-NP_014092.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:50273-51400:- | gene-YNL307C_CENPK1137D | rna-NM_001183145.1_CENPK1137D | cds-NP_014092.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:47266-48393:- | gene-YNL307C_EthanolRed | rna-NM_001183145.1_EthanolRed | cds-NP_014092.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:48165-49292:- | gene-YNL307C_FaliES1 | rna-NM_001183145.1_FaliES1 | cds-NP_014092.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000390.1:6226-7353:+ | gene-YNL307C_JAY291 | rna-NM_001183145.1_JAY291 | cds-NP_014092.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:59838-60965:- | gene-YNL307C_MUCL30387 | rna-NM_001183145.1_MUCL30387 | cds-NP_014092.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:52869-53996:- | gene-YNL307C_MUCL30388 | rna-NM_001183145.1_MUCL30388 | cds-NP_014092.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:48212-49339:- | gene-YNL307C_MUCL39482 | rna-NM_001183145.1_MUCL39482 | cds-NP_014092.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:49904-51031:- | gene-YNL307C_MUCL42920 | rna-NM_001183145.1_MUCL42920 | cds-NP_014092.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:56415-57542:- | gene-YNL307C_NCIM3186 | rna-NM_001183145.1_NCIM3186 | cds-NP_014092.1_NCIM3186 | 92.1 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:49544-50671:- | gene-YNL307C_NCYC1407 | rna-NM_001183145.1_NCYC1407 | cds-NP_014092.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:46746-47873:- | gene-YNL307C_PE2H3 | rna-NM_001183145.1_PE2H3 | cds-NP_014092.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:46134-47261:- | gene-YNL307C_PE2H4 | rna-NM_001183145.1_PE2H4 | cds-NP_014092.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:56446-57573:- | gene-YNL307C_S288C | rna-NM_001183145.1_S288C | cds-NP_014092.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:39655-40782:+ | gene-YNL307C_SA1 | rna-NM_001183145.1_SA1 | cds-NP_014092.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:49022-50149:- | gene-YNL307C_ThermosaccDry | rna-NM_001183145.1_ThermosaccDry | cds-NP_014092.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:61561-62688:- | gene-YNL307C_VR1 | rna-NM_001183145.1_VR1 | cds-NP_014092.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:40236-41363:- | gene-YNL307C_ZTW1 | rna-NM_001183145.1_ZTW1 | cds-NP_014092.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:58272-59399:- | gene-YNL307C_Sparadoxus | rna-NM_001183145.1_Sparadoxus | cds-NP_014092.1_Sparadoxus | 93.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |