Gene name: MCA1
Reference locus (S288C): YOR197W
Gene biotype: protein_coding
Description: Metacaspase-1; Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization; Belongs to the peptidase C14B family
Top 10 interactors (score): NMA111 (0.969); CDC48 (0.958); BXI1 (0.948); AIF1 (0.944); NUC1 (0.943); YDJ1 (0.837); NDI1 (0.816); BIR1 (0.798); RNQ1 (0.796); WWM1 (0.787); KEX1 (0.776); RIM13 (0.768); SDD2 (0.729); HSP104 (0.728); ISC1 (0.71); CNE1 (0.697); TRS65 (0.687); HSC82 (0.676); SRO77 (0.676); URE2 (0.647)
Homologues (species, bitscore): MC1 (Arabidopsis thaliana, 192.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:707872-709170:+ | gene-YOR197W_AKU4011 | rna-NM_001183616.3_AKU4011 | cds-NP_014840.4_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:109912-111210:+ | gene-YOR197W_BG1 | rna-NM_001183616.3_BG1 | cds-NP_014840.4_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:692703-694001:+ | gene-YOR197W_Bruggeman | rna-NM_001183616.3_Bruggeman | cds-NP_014840.4_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:693986-695284:+ | gene-YOR197W_CAT1 | rna-NM_001183616.3_CAT1 | cds-NP_014840.4_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:690859-692157:+ | gene-YOR197W_CBS1585 | rna-NM_001183616.3_CBS1585 | cds-NP_014840.4_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:689548-690846:+ | gene-YOR197W_CBS436 | rna-NM_001183616.3_CBS436 | cds-NP_014840.4_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:687977-689275:+ | gene-YOR197W_CBS6412 | rna-NM_001183616.3_CBS6412 | cds-NP_014840.4_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:696616-697914:+ | gene-YOR197W_CBS6413 | rna-NM_001183616.3_CBS6413 | cds-NP_014840.4_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:716841-718139:+ | gene-YOR197W_CENPK1137D | rna-NM_001183616.3_CENPK1137D | cds-NP_014840.4_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:684002-685300:+ | gene-YOR197W_EthanolRed | rna-NM_001183616.3_EthanolRed | cds-NP_014840.4_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:689399-690697:+ | gene-YOR197W_FaliES1 | rna-NM_001183616.3_FaliES1 | cds-NP_014840.4_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:136051-137349:- | gene-YOR197W_JAY291 | rna-NM_001183616.3_JAY291 | cds-NP_014840.4_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:696669-697967:+ | gene-YOR197W_MUCL30387 | rna-NM_001183616.3_MUCL30387 | cds-NP_014840.4_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:704087-705385:+ | gene-YOR197W_MUCL30388 | rna-NM_001183616.3_MUCL30388 | cds-NP_014840.4_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:698188-699486:+ | gene-YOR197W_MUCL39482 | rna-NM_001183616.3_MUCL39482 | cds-NP_014840.4_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:707772-709070:+ | gene-YOR197W_MUCL42920 | rna-NM_001183616.3_MUCL42920 | cds-NP_014840.4_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:716975-718273:+ | gene-YOR197W_NCIM3186 | rna-NM_001183616.3_NCIM3186 | cds-NP_014840.4_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:698286-699584:+ | gene-YOR197W_NCYC1407 | rna-NM_001183616.3_NCYC1407 | cds-NP_014840.4_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:697684-698982:+ | gene-YOR197W_PE2H3 | rna-NM_001183616.3_PE2H3 | cds-NP_014840.4_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:708061-709359:+ | gene-YOR197W_PE2H4 | rna-NM_001183616.3_PE2H4 | cds-NP_014840.4_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:717086-718384:+ | gene-YOR197W_S288C | rna-NM_001183616.3_S288C | cds-NP_014840.4_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:127092-128390:+ | gene-YOR197W_SA1 | rna-NM_001183616.3_SA1 | cds-NP_014840.4_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:688584-689882:+ | gene-YOR197W_ThermosaccDry | rna-NM_001183616.3_ThermosaccDry | cds-NP_014840.4_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:752125-753423:+ | gene-YOR197W_VR1 | rna-NM_001183616.3_VR1 | cds-NP_014840.4_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:421499-422797:+ | gene-YOR197W_ZTW1 | rna-NM_001183616.3_ZTW1 | cds-NP_014840.4_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:694496-695782:+ | gene-YOR197W_Sparadoxus | rna-NM_001183616.3_Sparadoxus | cds-NP_014840.4_Sparadoxus | 92.0 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |