Gene name: MAK21
Reference locus (S288C): YDR060W
Gene biotype: protein_coding
Description: Ribosome biogenesis protein MAK21; Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
Top 10 interactors (score): ERB1 (0.999); SSF1 (0.999); EBP2 (0.999); NUG1 (0.999); DRS1 (0.999); RRP1 (0.999); NOP58 (0.999); UTP13 (0.999); HAS1 (0.999); NOC2 (0.999); RRP12 (0.999); BRX1 (0.999); DBP9 (0.999); RPF2 (0.999); NOP2 (0.999); NOP15 (0.999); PUF6 (0.999); SPB1 (0.999); RRP5 (0.999); YTM1 (0.999)
Homologues (species, bitscore): CEBPZ (Homo sapiens, 347.4); Cebpz (Mus musculus, 361.7); cebpz (Danio rerio, 376.7); cebpz (Xenopus tropicalis, 345.9); CG7839 (Drosophila melanogaster, 160.2); F23B12.7 (Caenorhabditis elegans, 199.5); EDA25 (Arabidopsis thaliana, 280.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:548191-551268:+ | gene-YDR060W_AKU4011 | rna-NM_001180368.3_AKU4011 | cds-NP_010345.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:575482-578845:- | gene-YDR060W_BG1 | rna-NM_001180368.3_BG1 | cds-NP_010345.3_BG1 | 91.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:580498-583575:+ | gene-YDR060W_Bruggeman | rna-NM_001180368.3_Bruggeman | cds-NP_010345.3_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:563531-566608:+ | gene-YDR060W_CAT1 | rna-NM_001180368.3_CAT1 | cds-NP_010345.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:539145-542222:+ | gene-YDR060W_CBS1585 | rna-NM_001180368.3_CBS1585 | cds-NP_010345.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:564312-567389:+ | gene-YDR060W_CBS436 | rna-NM_001180368.3_CBS436 | cds-NP_010345.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:535557-538634:+ | gene-YDR060W_CBS6412 | rna-NM_001180368.3_CBS6412 | cds-NP_010345.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:564226-567303:+ | gene-YDR060W_CBS6413 | rna-NM_001180368.3_CBS6413 | cds-NP_010345.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:569615-572692:+ | gene-YDR060W_CENPK1137D | rna-NM_001180368.3_CENPK1137D | cds-NP_010345.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:550009-553086:+ | gene-YDR060W_EthanolRed | rna-NM_001180368.3_EthanolRed | cds-NP_010345.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:556455-559532:+ | gene-YDR060W_FaliES1 | rna-NM_001180368.3_FaliES1 | cds-NP_010345.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:71273-74350:- | gene-YDR060W_JAY291 | rna-NM_001180368.3_JAY291 | cds-NP_010345.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:565191-568268:+ | gene-YDR060W_MUCL30387 | rna-NM_001180368.3_MUCL30387 | cds-NP_010345.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:555581-558658:+ | gene-YDR060W_MUCL30388 | rna-NM_001180368.3_MUCL30388 | cds-NP_010345.3_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:540516-543593:+ | gene-YDR060W_MUCL39482 | rna-NM_001180368.3_MUCL39482 | cds-NP_010345.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:470991-474068:+ | gene-YDR060W_MUCL42920 | rna-NM_001180368.3_MUCL42920 | cds-NP_010345.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:570572-573649:+ | gene-YDR060W_NCIM3186 | rna-NM_001180368.3_NCIM3186 | cds-NP_010345.3_NCIM3186 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:539450-542527:+ | gene-YDR060W_NCYC1407 | rna-NM_001180368.3_NCYC1407 | cds-NP_010345.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:559089-562166:+ | gene-YDR060W_PE2H3 | rna-NM_001180368.3_PE2H3 | cds-NP_010345.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:558394-561471:+ | gene-YDR060W_PE2H4 | rna-NM_001180368.3_PE2H4 | cds-NP_010345.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:570649-573726:+ | gene-YDR060W_S288C | rna-NM_001180368.3_S288C | cds-NP_010345.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:71765-74842:- | gene-YDR060W_SA1 | rna-NM_001180368.3_SA1 | cds-NP_010345.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:556148-559225:+ | gene-YDR060W_ThermosaccDry | rna-NM_001180368.3_ThermosaccDry | cds-NP_010345.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:568903-571980:+ | gene-YDR060W_VR1 | rna-NM_001180368.3_VR1 | cds-NP_010345.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:553800-556877:+ | gene-YDR060W_ZTW1 | rna-NM_001180368.3_ZTW1 | cds-NP_010345.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:558659-561712:+ | gene-YDR060W_Sparadoxus | rna-NM_001180368.3_Sparadoxus | cds-NP_010345.3_Sparadoxus | 88.4 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |