Gene name: MAF1
Reference locus (S288C): YDR005C
Gene biotype: protein_coding
Description: Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions
Top 10 interactors (score): RPO31 (0.993); RET1 (0.968); SCH9 (0.958); RPC82 (0.896); RPC34 (0.881); FIS1 (0.861); LOS1 (0.839); BRF1 (0.834); BDP1 (0.832); RPC40 (0.814); RRN3 (0.813); YOR111W (0.782); PUS1 (0.779); RPC37 (0.769); RPC53 (0.766); RPC31 (0.751); TOR1 (0.742); MOD5 (0.737); RPC11 (0.733); MSN5 (0.731)
Homologues (species, bitscore): MAF1 (Homo sapiens, 69.3); Maf1 (Mus musculus, 68.2); maf1 (Danio rerio, 65.5); Maf1 (Drosophila melanogaster, 67.0); C43H8.2 (Caenorhabditis elegans, 52.8); AT5G13240 (Arabidopsis thaliana, 61.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:442087-443354:- | gene-YDR005C_AKU4011 | rna-NM_001180313.1_AKU4011 | cds-NP_010288.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:105797-107064:+ | gene-YDR005C_BG1 | rna-NM_001180313.1_BG1 | cds-NP_010288.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:462693-463960:- | gene-YDR005C_Bruggeman | rna-NM_001180313.1_Bruggeman | cds-NP_010288.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:455538-456805:- | gene-YDR005C_CAT1 | rna-NM_001180313.1_CAT1 | cds-NP_010288.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:439299-440566:- | gene-YDR005C_CBS1585 | rna-NM_001180313.1_CBS1585 | cds-NP_010288.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:456068-457335:- | gene-YDR005C_CBS436 | rna-NM_001180313.1_CBS436 | cds-NP_010288.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:436546-437813:- | gene-YDR005C_CBS6412 | rna-NM_001180313.1_CBS6412 | cds-NP_010288.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:458237-459504:- | gene-YDR005C_CBS6413 | rna-NM_001180313.1_CBS6413 | cds-NP_010288.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:455699-456966:- | gene-YDR005C_CENPK1137D | rna-NM_001180313.1_CENPK1137D | cds-NP_010288.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:450918-452185:- | gene-YDR005C_EthanolRed | rna-NM_001180313.1_EthanolRed | cds-NP_010288.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:457089-458356:- | gene-YDR005C_FaliES1 | rna-NM_001180313.1_FaliES1 | cds-NP_010288.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000442.1:13703-14970:+ | gene-YDR005C_JAY291 | rna-NM_001180313.1_JAY291 | cds-NP_010288.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:456566-457833:- | gene-YDR005C_MUCL30387 | rna-NM_001180313.1_MUCL30387 | cds-NP_010288.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:447026-448293:- | gene-YDR005C_MUCL30388 | rna-NM_001180313.1_MUCL30388 | cds-NP_010288.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:440668-441935:- | gene-YDR005C_MUCL39482 | rna-NM_001180313.1_MUCL39482 | cds-NP_010288.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:362099-363366:- | gene-YDR005C_MUCL42920 | rna-NM_001180313.1_MUCL42920 | cds-NP_010288.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:456759-458026:- | gene-YDR005C_NCIM3186 | rna-NM_001180313.1_NCIM3186 | cds-NP_010288.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:439590-440857:- | gene-YDR005C_NCYC1407 | rna-NM_001180313.1_NCYC1407 | cds-NP_010288.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:455205-456472:- | gene-YDR005C_PE2H3 | rna-NM_001180313.1_PE2H3 | cds-NP_010288.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:454510-455777:- | gene-YDR005C_PE2H4 | rna-NM_001180313.1_PE2H4 | cds-NP_010288.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:456836-458103:- | gene-YDR005C_S288C | rna-NM_001180313.1_S288C | cds-NP_010288.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000099.1:13864-15131:+ | gene-YDR005C_SA1 | rna-NM_001180313.1_SA1 | cds-NP_010288.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:456568-457835:- | gene-YDR005C_ThermosaccDry | rna-NM_001180313.1_ThermosaccDry | cds-NP_010288.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:461008-462275:- | gene-YDR005C_VR1 | rna-NM_001180313.1_VR1 | cds-NP_010288.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:454465-455732:- | gene-YDR005C_ZTW1 | rna-NM_001180313.1_ZTW1 | cds-NP_010288.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:458812-460086:- | gene-YDR005C_Sparadoxus | rna-NM_001180313.1_Sparadoxus | cds-NP_010288.1_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |