Gene name: MAE1
Reference locus (S288C): YKL029C
Gene biotype: protein_coding
Description: Malate dehydrogenase (oxaloacetate-decarboxylating); Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
Top 10 interactors (score): PYK2 (0.997); CDC19 (0.992); MDH2 (0.992); PYC2 (0.988); MDH3 (0.987); FUM1 (0.986); MDH1 (0.986); PDB1 (0.978); DAL7 (0.972); PDA1 (0.971); PYC1 (0.969); MLS1 (0.961); CYB2 (0.952); PDC1 (0.947); ILV2 (0.934); CIT3 (0.925); POX1 (0.918); ACH1 (0.918); CIT1 (0.917); CIT2 (0.912)
Homologues (species, bitscore): ME1 (Homo sapiens, 362.8); Me1 (Mus musculus, 363.6); me2 (Danio rerio, 357.8); me2 (Xenopus tropicalis, 353.2); Men-b (Drosophila melanogaster, 339.7); men-1 (Caenorhabditis elegans, 351.3); NADP-ME4 (Arabidopsis thaliana, 366.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:368727-370736:- | gene-YKL029C_AKU4011 | rna-NM_001179595.1_AKU4011 | cds-NP_012896.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:273320-275329:+ | gene-YKL029C_BG1 | rna-NM_001179595.1_BG1 | cds-NP_012896.1_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:390439-392448:- | gene-YKL029C_Bruggeman | rna-NM_001179595.1_Bruggeman | cds-NP_012896.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:384842-386851:- | gene-YKL029C_CAT1 | rna-NM_001179595.1_CAT1 | cds-NP_012896.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:381454-383463:- | gene-YKL029C_CBS1585 | rna-NM_001179595.1_CBS1585 | cds-NP_012896.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:380137-382146:- | gene-YKL029C_CBS436 | rna-NM_001179595.1_CBS436 | cds-NP_012896.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:365593-367602:- | gene-YKL029C_CBS6412 | rna-NM_001179595.1_CBS6412 | cds-NP_012896.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:381306-383315:- | gene-YKL029C_CBS6413 | rna-NM_001179595.1_CBS6413 | cds-NP_012896.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:382355-384364:- | gene-YKL029C_CENPK1137D | rna-NM_001179595.1_CENPK1137D | cds-NP_012896.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:379212-381221:- | gene-YKL029C_EthanolRed | rna-NM_001179595.1_EthanolRed | cds-NP_012896.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:381316-383325:- | gene-YKL029C_FaliES1 | rna-NM_001179595.1_FaliES1 | cds-NP_012896.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000142.1:47877-49886:+ | gene-YKL029C_JAY291 | rna-NM_001179595.1_JAY291 | cds-NP_012896.1_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:389478-391487:- | gene-YKL029C_MUCL30387 | rna-NM_001179595.1_MUCL30387 | cds-NP_012896.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:385093-387102:- | gene-YKL029C_MUCL30388 | rna-NM_001179595.1_MUCL30388 | cds-NP_012896.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:380758-382767:- | gene-YKL029C_MUCL39482 | rna-NM_001179595.1_MUCL39482 | cds-NP_012896.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:386181-388190:- | gene-YKL029C_MUCL42920 | rna-NM_001179595.1_MUCL42920 | cds-NP_012896.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:382705-384714:- | gene-YKL029C_NCIM3186 | rna-NM_001179595.1_NCIM3186 | cds-NP_012896.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:380949-382958:- | gene-YKL029C_NCYC1407 | rna-NM_001179595.1_NCYC1407 | cds-NP_012896.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:405484-407493:- | gene-YKL029C_PE2H3 | rna-NM_001179595.1_PE2H3 | cds-NP_012896.1_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:390219-392228:- | gene-YKL029C_PE2H4 | rna-NM_001179595.1_PE2H4 | cds-NP_012896.1_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:382716-384725:- | gene-YKL029C_S288C | rna-NM_001179595.1_S288C | cds-NP_012896.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:60803-62812:- | gene-YKL029C_SA1 | rna-NM_001179595.1_SA1 | cds-NP_012896.1_SA1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:381414-383423:- | gene-YKL029C_ThermosaccDry | rna-NM_001179595.1_ThermosaccDry | cds-NP_012896.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:380499-382508:- | gene-YKL029C_VR1 | rna-NM_001179595.1_VR1 | cds-NP_012896.1_VR1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:379439-381448:- | gene-YKL029C_ZTW1 | rna-NM_001179595.1_ZTW1 | cds-NP_012896.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:398260-400272:- | gene-YKL029C_Sparadoxus | rna-NM_001179595.1_Sparadoxus | cds-NP_012896.1_Sparadoxus | 91.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |