Gene name: MAD3
Reference locus (S288C): YJL013C
Gene biotype: protein_coding
Description: Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication
Top 10 interactors (score): MAD2 (0.999); BUB3 (0.999); CDC20 (0.999); CDC5 (0.999); MPS1 (0.998); CDC27 (0.996); APC1 (0.996); APC4 (0.994); CDC23 (0.994); DOC1 (0.993); CDC16 (0.992); NDC80 (0.992); IPL1 (0.992); CIN8 (0.991); ESP1 (0.987); MAD1 (0.986); CDH1 (0.982); KAR3 (0.98); KIP1 (0.959); BUB2 (0.955)
Homologues (species, bitscore): BUB1B (Homo sapiens, 96.3); Bub1b (Mus musculus, 93.6); bub1bb (Danio rerio, 104.8); bub1b (Xenopus tropicalis, 85.1); BubR1 (Drosophila melanogaster, 85.9); BUBR1 (Arabidopsis thaliana, 91.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:392643-394190:- | gene-YJL013C_AKU4011 | rna-NM_001181447.3_AKU4011 | cds-NP_012521.3_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:219972-221519:+ | gene-YJL013C_BG1 | rna-NM_001181447.3_BG1 | cds-NP_012521.3_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:406731-408278:- | gene-YJL013C_Bruggeman | rna-NM_001181447.3_Bruggeman | cds-NP_012521.3_Bruggeman | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:410712-412259:- | gene-YJL013C_CAT1 | rna-NM_001181447.3_CAT1 | cds-NP_012521.3_CAT1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:404232-405779:- | gene-YJL013C_CBS1585 | rna-NM_001181447.3_CBS1585 | cds-NP_012521.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:422608-424155:- | gene-YJL013C_CBS436 | rna-NM_001181447.3_CBS436 | cds-NP_012521.3_CBS436 | 98.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:392457-394004:- | gene-YJL013C_CBS6412 | rna-NM_001181447.3_CBS6412 | cds-NP_012521.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:394672-396219:- | gene-YJL013C_CBS6413 | rna-NM_001181447.3_CBS6413 | cds-NP_012521.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:391914-393461:- | gene-YJL013C_CENPK1137D | rna-NM_001181447.3_CENPK1137D | cds-NP_012521.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:395516-397063:- | gene-YJL013C_EthanolRed | rna-NM_001181447.3_EthanolRed | cds-NP_012521.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:408261-409808:- | gene-YJL013C_FaliES1 | rna-NM_001181447.3_FaliES1 | cds-NP_012521.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000200.1:5778-7325:+ | gene-YJL013C_JAY291 | rna-NM_001181447.3_JAY291 | cds-NP_012521.3_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:407070-408617:- | gene-YJL013C_MUCL30387 | rna-NM_001181447.3_MUCL30387 | cds-NP_012521.3_MUCL30387 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:403046-404593:- | gene-YJL013C_MUCL30388 | rna-NM_001181447.3_MUCL30388 | cds-NP_012521.3_MUCL30388 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:397549-399096:- | gene-YJL013C_MUCL39482 | rna-NM_001181447.3_MUCL39482 | cds-NP_012521.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:403003-404550:- | gene-YJL013C_MUCL42920 | rna-NM_001181447.3_MUCL42920 | cds-NP_012521.3_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:409472-411019:- | gene-YJL013C_NCIM3186 | rna-NM_001181447.3_NCIM3186 | cds-NP_012521.3_NCIM3186 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:395462-397009:- | gene-YJL013C_NCYC1407 | rna-NM_001181447.3_NCYC1407 | cds-NP_012521.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:407612-409159:- | gene-YJL013C_PE2H3 | rna-NM_001181447.3_PE2H3 | cds-NP_012521.3_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:407219-408766:- | gene-YJL013C_PE2H4 | rna-NM_001181447.3_PE2H4 | cds-NP_012521.3_PE2H4 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:409493-411040:- | gene-YJL013C_S288C | rna-NM_001181447.3_S288C | cds-NP_012521.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000003.1:205139-206686:- | gene-YJL013C_SA1 | rna-NM_001181447.3_SA1 | cds-NP_012521.3_SA1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:401920-403467:- | gene-YJL013C_ThermosaccDry | rna-NM_001181447.3_ThermosaccDry | cds-NP_012521.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:403611-405158:- | gene-YJL013C_VR1 | rna-NM_001181447.3_VR1 | cds-NP_012521.3_VR1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:382418-383965:- | gene-YJL013C_ZTW1 | rna-NM_001181447.3_ZTW1 | cds-NP_012521.3_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:408024-409570:- | gene-YJL013C_Sparadoxus | rna-NM_001181447.3_Sparadoxus | cds-NP_012521.3_Sparadoxus | 85.3 | 99.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |