Gene name: MAD1
Reference locus (S288C): YGL086W
Gene biotype: protein_coding
Description: Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability; Belongs to the MAD1 family
Top 10 interactors (score): MAD2 (0.999); MPS1 (0.999); BUB1 (0.997); BUB3 (0.995); MAD3 (0.986); CDC20 (0.977); MLP2 (0.945); MLP1 (0.941); BUB2 (0.938); BFA1 (0.909); KAR3 (0.888); CIN8 (0.854); BIM1 (0.843); SLK19 (0.832); CIN1 (0.822); CTF19 (0.816); CHL4 (0.807); MCM22 (0.806); CTF3 (0.803); TUB3 (0.797)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:350123-352372:+ | gene-YGL086W_AKU4011 | rna-NM_001180951.3_AKU4011 | cds-NP_011429.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:53032-55293:- | gene-YGL086W_BG1 | rna-NM_001180951.3_BG1 | cds-NP_011429.3_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:352616-354865:+ | gene-YGL086W_Bruggeman | rna-NM_001180951.3_Bruggeman | cds-NP_011429.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:349509-351770:+ | gene-YGL086W_CAT1 | rna-NM_001180951.3_CAT1 | cds-NP_011429.3_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:353448-355697:+ | gene-YGL086W_CBS1585 | rna-NM_001180951.3_CBS1585 | cds-NP_011429.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:347733-349982:+ | gene-YGL086W_CBS436 | rna-NM_001180951.3_CBS436 | cds-NP_011429.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:337829-340078:+ | gene-YGL086W_CBS6412 | rna-NM_001180951.3_CBS6412 | cds-NP_011429.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:347754-350003:+ | gene-YGL086W_CBS6413 | rna-NM_001180951.3_CBS6413 | cds-NP_011429.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:347306-349555:+ | gene-YGL086W_CENPK1137D | rna-NM_001180951.3_CENPK1137D | cds-NP_011429.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:339208-341457:+ | gene-YGL086W_EthanolRed | rna-NM_001180951.3_EthanolRed | cds-NP_011429.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:341769-344018:+ | gene-YGL086W_FaliES1 | rna-NM_001180951.3_FaliES1 | cds-NP_011429.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000369.1:27380-29641:+ | gene-YGL086W_JAY291 | rna-NM_001180951.3_JAY291 | cds-NP_011429.3_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:349593-351842:+ | gene-YGL086W_MUCL30387 | rna-NM_001180951.3_MUCL30387 | cds-NP_011429.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:352579-354828:+ | gene-YGL086W_MUCL30388 | rna-NM_001180951.3_MUCL30388 | cds-NP_011429.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:349976-352225:+ | gene-YGL086W_MUCL39482 | rna-NM_001180951.3_MUCL39482 | cds-NP_011429.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:354504-356753:+ | gene-YGL086W_MUCL42920 | rna-NM_001180951.3_MUCL42920 | cds-NP_011429.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:347119-349368:+ | gene-YGL086W_NCIM3186 | rna-NM_001180951.3_NCIM3186 | cds-NP_011429.3_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:341511-343760:+ | gene-YGL086W_NCYC1407 | rna-NM_001180951.3_NCYC1407 | cds-NP_011429.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:343146-345407:+ | gene-YGL086W_PE2H3 | rna-NM_001180951.3_PE2H3 | cds-NP_011429.3_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:348143-350392:+ | gene-YGL086W_PE2H4 | rna-NM_001180951.3_PE2H4 | cds-NP_011429.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:347119-349368:+ | gene-YGL086W_S288C | rna-NM_001180951.3_S288C | cds-NP_011429.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000089.1:24500-26782:+ | gene-YGL086W_SA1 | rna-NM_001180951.3_SA1 | cds-NP_011429.3_SA1 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:342022-344271:+ | gene-YGL086W_ThermosaccDry | rna-NM_001180951.3_ThermosaccDry | cds-NP_011429.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:451884-454136:+ | gene-YGL086W_VR1 | rna-NM_001180951.3_VR1 | cds-NP_011429.3_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:339376-341625:+ | gene-YGL086W_ZTW1 | rna-NM_001180951.3_ZTW1 | cds-NP_011429.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:345020-347270:+ | gene-YGL086W_Sparadoxus | rna-NM_001180951.3_Sparadoxus | cds-NP_011429.3_Sparadoxus | 87.3 | 98.9 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |