Gene name: LYS4
Reference locus (S288C): YDR234W
Gene biotype: protein_coding
Description: Homoaconitase, mitochondrial; Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
Top 10 interactors (score): ACO2 (0.997); LYS12 (0.996); LYS2 (0.991); LYS21 (0.982); LYS1 (0.982); LYS20 (0.981); LEU2 (0.974); LYS9 (0.962); FUM1 (0.958); MRPL11 (0.922); LEU1 (0.913); ADE6 (0.906); PDB1 (0.896); MRPL7 (0.891); ILV3 (0.89); SDH2 (0.845); IDH1 (0.841); AAT1 (0.837); LAT1 (0.817); MRPL4 (0.816)
Homologues (species, bitscore): ACO2 (Homo sapiens, 139.8); Aco2 (Mus musculus, 138.7); aco2 (Danio rerio, 145.6); aco2 (Xenopus tropicalis, 127.1); Acon (Drosophila melanogaster, 144.1); aco-2 (Caenorhabditis elegans, 131.7); IIL1 (Arabidopsis thaliana, 171.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:887805-889886:+ | gene-YDR234W_AKU4011 | rna-NM_001180542.3_AKU4011 | cds-NP_010520.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:235922-238003:- | gene-YDR234W_BG1 | rna-NM_001180542.3_BG1 | cds-NP_010520.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:920131-922212:+ | gene-YDR234W_Bruggeman | rna-NM_001180542.3_Bruggeman | cds-NP_010520.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:907417-909498:+ | gene-YDR234W_CAT1 | rna-NM_001180542.3_CAT1 | cds-NP_010520.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:878154-880235:+ | gene-YDR234W_CBS1585 | rna-NM_001180542.3_CBS1585 | cds-NP_010520.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:907184-909265:+ | gene-YDR234W_CBS436 | rna-NM_001180542.3_CBS436 | cds-NP_010520.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:874914-876995:+ | gene-YDR234W_CBS6412 | rna-NM_001180542.3_CBS6412 | cds-NP_010520.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:905516-907597:+ | gene-YDR234W_CBS6413 | rna-NM_001180542.3_CBS6413 | cds-NP_010520.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:930059-932140:+ | gene-YDR234W_CENPK1137D | rna-NM_001180542.3_CENPK1137D | cds-NP_010520.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:888538-890619:+ | gene-YDR234W_EthanolRed | rna-NM_001180542.3_EthanolRed | cds-NP_010520.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:896740-898821:+ | gene-YDR234W_FaliES1 | rna-NM_001180542.3_FaliES1 | cds-NP_010520.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000348.1:12773-14854:- | gene-YDR234W_JAY291 | rna-NM_001180542.3_JAY291 | cds-NP_010520.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:906029-908110:+ | gene-YDR234W_MUCL30387 | rna-NM_001180542.3_MUCL30387 | cds-NP_010520.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:894059-896140:+ | gene-YDR234W_MUCL30388 | rna-NM_001180542.3_MUCL30388 | cds-NP_010520.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:879559-881640:+ | gene-YDR234W_MUCL39482 | rna-NM_001180542.3_MUCL39482 | cds-NP_010520.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:818834-820915:+ | gene-YDR234W_MUCL42920 | rna-NM_001180542.3_MUCL42920 | cds-NP_010520.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:931052-933133:+ | gene-YDR234W_NCIM3186 | rna-NM_001180542.3_NCIM3186 | cds-NP_010520.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:883227-885308:+ | gene-YDR234W_NCYC1407 | rna-NM_001180542.3_NCYC1407 | cds-NP_010520.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:899486-901567:+ | gene-YDR234W_PE2H3 | rna-NM_001180542.3_PE2H3 | cds-NP_010520.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:904763-906844:+ | gene-YDR234W_PE2H4 | rna-NM_001180542.3_PE2H4 | cds-NP_010520.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:931129-933210:+ | gene-YDR234W_S288C | rna-NM_001180542.3_S288C | cds-NP_010520.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:137323-139404:+ | gene-YDR234W_SA1 | rna-NM_001180542.3_SA1 | cds-NP_010520.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:894894-896975:+ | gene-YDR234W_ThermosaccDry | rna-NM_001180542.3_ThermosaccDry | cds-NP_010520.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:910086-912167:+ | gene-YDR234W_VR1 | rna-NM_001180542.3_VR1 | cds-NP_010520.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:157576-159657:+ | gene-YDR234W_ZTW1 | rna-NM_001180542.3_ZTW1 | cds-NP_010520.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:899755-901836:+ | gene-YDR234W_Sparadoxus | rna-NM_001180542.3_Sparadoxus | cds-NP_010520.3_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |