Gene name: LYS21
Reference locus (S288C): YDL131W
Gene biotype: protein_coding
Description: Homocitrate synthase, mitochondrial; Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family
Top 10 interactors (score): LYS20 (0.996); LYS4 (0.982); ACO2 (0.956); LEU4 (0.948); LYS12 (0.946); LYS9 (0.939); ACS2 (0.927); ACS1 (0.921); LEU9 (0.921); ERG10 (0.92); ACC1 (0.917); HFA1 (0.913); LAT1 (0.911); DAL7 (0.906); ACH1 (0.901); MLS1 (0.901); LSC1 (0.889); LSC2 (0.86); LEU1 (0.858); ARG5,6 (0.851)
Homologues (species, bitscore): hmgcl (Danio rerio, 55.1); CG10399 (Drosophila melanogaster, 53.9); Y71G12B.10 (Caenorhabditis elegans, 51.2); IMS2 (Arabidopsis thaliana, 152.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:212008-213329:+ | gene-YDL131W_AKU4011 | rna-NM_001180190.1_AKU4011 | cds-NP_010151.1_AKU4011 | 83.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:336636-337958:- | gene-YDL131W_BG1 | rna-NM_001180190.1_BG1 | cds-NP_010151.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:228679-230499:+ | gene-YDL131W_Bruggeman | rna-NM_001180190.1_Bruggeman | cds-NP_010151.1_Bruggeman | 72.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:226180-227502:+ | gene-YDL131W_CAT1 | rna-NM_001180190.1_CAT1 | cds-NP_010151.1_CAT1 | 54.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:210273-211594:+ | gene-YDL131W_CBS1585 | rna-NM_001180190.1_CBS1585 | cds-NP_010151.1_CBS1585 | 62.2 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:226942-228263:+ | gene-YDL131W_CBS436 | rna-NM_001180190.1_CBS436 | cds-NP_010151.1_CBS436 | 90.2 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:209075-210019:+ | gene-YDL131W_CBS6412 | rna-NM_001180190.1_CBS6412 | cds-NP_010151.1_CBS6412 | 71.3 | 71.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:228433-229754:+ | gene-YDL131W_CBS6413 | rna-NM_001180190.1_CBS6413 | cds-NP_010151.1_CBS6413 | 81.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:226166-227488:+ | gene-YDL131W_CENPK1137D | rna-NM_001180190.1_CENPK1137D | cds-NP_010151.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:223037-224359:+ | gene-YDL131W_EthanolRed | rna-NM_001180190.1_EthanolRed | cds-NP_010151.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:228758-230329:+ | gene-YDL131W_FaliES1 | rna-NM_001180190.1_FaliES1 | cds-NP_010151.1_FaliES1 | 84.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:1-391:+ | gene-YDL131W_JAY291 | rna-NM_001180190.1_JAY291 | cds-NP_010151.1_JAY291 | 29.3 | 29.5 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:227127-228553:+ | gene-YDL131W_MUCL30387 | rna-NM_001180190.1_MUCL30387 | cds-NP_010151.1_MUCL30387 | 92.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:217995-219317:+ | gene-YDL131W_MUCL30388 | rna-NM_001180190.1_MUCL30388 | cds-NP_010151.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:211125-212696:+ | gene-YDL131W_MUCL39482 | rna-NM_001180190.1_MUCL39482 | cds-NP_010151.1_MUCL39482 | 83.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:133154-134482:+ | gene-YDL131W_MUCL42920 | rna-NM_001180190.1_MUCL42920 | cds-NP_010151.1_MUCL42920 | 94.5 | 99.2 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:227316-228638:+ | gene-YDL131W_NCIM3186 | rna-NM_001180190.1_NCIM3186 | cds-NP_010151.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:211406-212727:+ | gene-YDL131W_NCYC1407 | rna-NM_001180190.1_NCYC1407 | cds-NP_010151.1_NCYC1407 | 73.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:218169-219491:+ | gene-YDL131W_PE2H3 | rna-NM_001180190.1_PE2H3 | cds-NP_010151.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:218173-219495:+ | gene-YDL131W_PE2H4 | rna-NM_001180190.1_PE2H4 | cds-NP_010151.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:227393-228715:+ | gene-YDL131W_S288C | rna-NM_001180190.1_S288C | cds-NP_010151.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000043.1:92933-93401:+ | gene-YDL131W_SA1 | rna-NM_001180190.1_SA1 | cds-NP_010151.1_SA1 | 35.3 | 35.4 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:228519-229840:+ | gene-YDL131W_ThermosaccDry | rna-NM_001180190.1_ThermosaccDry | cds-NP_010151.1_ThermosaccDry | 87.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:230144-231964:+ | gene-YDL131W_VR1 | rna-NM_001180190.1_VR1 | cds-NP_010151.1_VR1 | 72.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:226449-227771:+ | gene-YDL131W_ZTW1 | rna-NM_001180190.1_ZTW1 | cds-NP_010151.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:228526-229848:+ | gene-YDL131W_Sparadoxus | rna-NM_001180190.1_Sparadoxus | cds-NP_010151.1_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |