Gene name: LYS20
Reference locus (S288C): YDL182W
Gene biotype: protein_coding
Description: Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family
Top 10 interactors (score): LYS21 (0.996); LYS4 (0.981); LYS9 (0.971); ACO2 (0.952); LEU4 (0.939); ACS2 (0.93); ACS1 (0.925); LEU9 (0.921); ERG10 (0.92); LYS12 (0.919); LYS1 (0.917); ACC1 (0.917); LAT1 (0.914); HFA1 (0.913); DAL7 (0.909); MLS1 (0.905); ACH1 (0.901); LSC2 (0.876); LSC1 (0.837); ARG5,6 (0.826)
Homologues (species, bitscore): hmgcl (Danio rerio, 55.1); CG10399 (Drosophila melanogaster, 57.0); Y71G12B.10 (Caenorhabditis elegans, 54.3); IMS2 (Arabidopsis thaliana, 154.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:117437-119221:+ | gene-YDL182W_AKU4011 | rna-NM_001180242.1_AKU4011 | cds-NP_010099.1_AKU4011 | 71.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:430490-431776:- | gene-YDL182W_BG1 | rna-NM_001180242.1_BG1 | cds-NP_010099.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:133779-135275:+ | gene-YDL182W_Bruggeman | rna-NM_001180242.1_Bruggeman | cds-NP_010099.1_Bruggeman | 85.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:132315-133604:+ | gene-YDL182W_CAT1 | rna-NM_001180242.1_CAT1 | cds-NP_010099.1_CAT1 | 96.9 | 99.8 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:115973-117259:+ | gene-YDL182W_CBS1585 | rna-NM_001180242.1_CBS1585 | cds-NP_010099.1_CBS1585 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:132933-134219:+ | gene-YDL182W_CBS436 | rna-NM_001180242.1_CBS436 | cds-NP_010099.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:115879-116822:+ | gene-YDL182W_CBS6412 | rna-NM_001180242.1_CBS6412 | cds-NP_010099.1_CBS6412 | 72.8 | 73.3 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:133849-135633:+ | gene-YDL182W_CBS6413 | rna-NM_001180242.1_CBS6413 | cds-NP_010099.1_CBS6413 | 71.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:132111-133397:+ | gene-YDL182W_CENPK1137D | rna-NM_001180242.1_CENPK1137D | cds-NP_010099.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:129575-130641:+ | gene-YDL182W_EthanolRed | rna-NM_001180242.1_EthanolRed | cds-NP_010099.1_EthanolRed | 82.6 | 82.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:134682-135967:+ | gene-YDL182W_FaliES1 | rna-NM_001180242.1_FaliES1 | cds-NP_010099.1_FaliES1 | 89.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000163.1:1-702:+ | gene-YDL182W_JAY291 | rna-NM_001180242.1_JAY291 | cds-NP_010099.1_JAY291 | 53.9 | 54.5 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:132045-133580:+ | gene-YDL182W_MUCL30387 | rna-NM_001180242.1_MUCL30387 | cds-NP_010099.1_MUCL30387 | 83.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:123941-125226:+ | gene-YDL182W_MUCL30388 | rna-NM_001180242.1_MUCL30388 | cds-NP_010099.1_MUCL30388 | 96.4 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:117116-118401:+ | gene-YDL182W_MUCL39482 | rna-NM_001180242.1_MUCL39482 | cds-NP_010099.1_MUCL39482 | 77.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | MBVV01000307.1:50970-51596:- | gene-YDL182W_MUCL42920 | rna-NM_001180242.1_MUCL42920 | cds-NP_010099.1_MUCL42920 | 48.3 | 48.7 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:133360-134646:+ | gene-YDL182W_NCIM3186 | rna-NM_001180242.1_NCIM3186 | cds-NP_010099.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:116755-118290:+ | gene-YDL182W_NCYC1407 | rna-NM_001180242.1_NCYC1407 | cds-NP_010099.1_NCYC1407 | 82.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:124314-125600:+ | gene-YDL182W_PE2H3 | rna-NM_001180242.1_PE2H3 | cds-NP_010099.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:124318-125604:+ | gene-YDL182W_PE2H4 | rna-NM_001180242.1_PE2H4 | cds-NP_010099.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:133437-134723:+ | gene-YDL182W_S288C | rna-NM_001180242.1_S288C | cds-NP_010099.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000110.1:1-427:- | gene-YDL182W_SA1 | rna-NM_001180242.1_SA1 | cds-NP_010099.1_SA1 | 33.1 | 33.1 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:134441-135727:+ | gene-YDL182W_ThermosaccDry | rna-NM_001180242.1_ThermosaccDry | cds-NP_010099.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:134875-136371:+ | gene-YDL182W_VR1 | rna-NM_001180242.1_VR1 | cds-NP_010099.1_VR1 | 85.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:132614-133901:+ | gene-YDL182W_ZTW1 | rna-NM_001180242.1_ZTW1 | cds-NP_010099.1_ZTW1 | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:134789-136075:+ | gene-YDL182W_Sparadoxus | rna-NM_001180242.1_Sparadoxus | cds-NP_010099.1_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |