Gene name: LYS2
Reference locus (S288C): YBR115C
Gene biotype: protein_coding
Description: L-aminoadipate-semialdehyde dehydrogenase; Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
Top 10 interactors (score): LYS9 (0.995); LYS4 (0.991); LYS5 (0.986); TRP5 (0.983); LEU2 (0.969); TRP1 (0.964); ARO8 (0.96); URA3 (0.96); ADE2 (0.958); HIS3 (0.957); HIS4 (0.95); LYS1 (0.948); MET17 (0.935); ADE6 (0.933); ACP1 (0.929); CDC60 (0.908); CAN1 (0.904); ILV3 (0.904); LEU1 (0.885); ADE5,7 (0.883)
Homologues (species, bitscore): AASDH (Homo sapiens, 79.7); Aasdh (Mus musculus, 79.7); acss3 (Danio rerio, 58.9); acsf2 (Xenopus tropicalis, 68.2); e (Drosophila melanogaster, 136.7); acs-21 (Caenorhabditis elegans, 81.6); AT5G35930 (Arabidopsis thaliana, 124.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:452146-456324:- | gene-YBR115C_AKU4011 | rna-NM_001178463.1_AKU4011 | cds-NP_009673.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:443180-447358:- | gene-YBR115C_BG1 | rna-NM_001178463.1_BG1 | cds-NP_009673.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:453919-458097:- | gene-YBR115C_Bruggeman | rna-NM_001178463.1_Bruggeman | cds-NP_009673.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:457140-461318:- | gene-YBR115C_CAT1 | rna-NM_001178463.1_CAT1 | cds-NP_009673.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:444429-448607:- | gene-YBR115C_CBS1585 | rna-NM_001178463.1_CBS1585 | cds-NP_009673.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:452498-456676:- | gene-YBR115C_CBS436 | rna-NM_001178463.1_CBS436 | cds-NP_009673.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:542658-546836:- | gene-YBR115C_CBS6412 | rna-NM_001178463.1_CBS6412 | cds-NP_009673.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:449558-453736:- | gene-YBR115C_CBS6413 | rna-NM_001178463.1_CBS6413 | cds-NP_009673.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:461646-465824:- | gene-YBR115C_CENPK1137D | rna-NM_001178463.1_CENPK1137D | cds-NP_009673.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:578898-583076:- | gene-YBR115C_EthanolRed | rna-NM_001178463.1_EthanolRed | cds-NP_009673.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:468181-472359:- | gene-YBR115C_FaliES1 | rna-NM_001178463.1_FaliES1 | cds-NP_009673.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000312.1:39083-43261:- | gene-YBR115C_JAY291 | rna-NM_001178463.1_JAY291 | cds-NP_009673.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:456572-460750:- | gene-YBR115C_MUCL30387 | rna-NM_001178463.1_MUCL30387 | cds-NP_009673.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:455180-459358:- | gene-YBR115C_MUCL30388 | rna-NM_001178463.1_MUCL30388 | cds-NP_009673.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:442572-446750:- | gene-YBR115C_MUCL39482 | rna-NM_001178463.1_MUCL39482 | cds-NP_009673.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:452229-456407:- | gene-YBR115C_MUCL42920 | rna-NM_001178463.1_MUCL42920 | cds-NP_009673.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:469545-473723:- | gene-YBR115C_NCIM3186 | rna-NM_001178463.1_NCIM3186 | cds-NP_009673.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:445350-449528:- | gene-YBR115C_NCYC1407 | rna-NM_001178463.1_NCYC1407 | cds-NP_009673.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:457928-462106:- | gene-YBR115C_PE2H3 | rna-NM_001178463.1_PE2H3 | cds-NP_009673.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:455604-459782:- | gene-YBR115C_PE2H4 | rna-NM_001178463.1_PE2H4 | cds-NP_009673.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:469748-473926:- | gene-YBR115C_S288C | rna-NM_001178463.1_S288C | cds-NP_009673.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000017.1:3828-8006:+ | gene-YBR115C_SA1 | rna-NM_001178463.1_SA1 | cds-NP_009673.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:467188-471366:- | gene-YBR115C_ThermosaccDry | rna-NM_001178463.1_ThermosaccDry | cds-NP_009673.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:449186-453364:- | gene-YBR115C_VR1 | rna-NM_001178463.1_VR1 | cds-NP_009673.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:442838-447016:- | gene-YBR115C_ZTW1 | rna-NM_001178463.1_ZTW1 | cds-NP_009673.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:480014-484192:- | gene-YBR115C_Sparadoxus | rna-NM_001178463.1_Sparadoxus | cds-NP_009673.1_Sparadoxus | 90.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |