Gene name: LYS12
Reference locus (S288C): YIL094C
Gene biotype: protein_coding
Description: Homoisocitrate dehydrogenase, mitochondrial; Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
Top 10 interactors (score): LYS4 (0.996); LYS9 (0.994); LSC2 (0.991); CIT1 (0.985); IDH1 (0.975); LYS1 (0.96); ARO8 (0.958); LYS21 (0.946); TPI1 (0.939); LYS20 (0.919); ARG5,6 (0.915); HIS4 (0.883); LSC1 (0.871); ACO2 (0.858); LYS14 (0.855); TRP5 (0.847); LYS5 (0.846); LYS2 (0.84); ILV3 (0.837); HIS1 (0.835)
Homologues (species, bitscore): IDH3A (Homo sapiens, 206.8); Idh3a (Mus musculus, 204.9); idh3a (Danio rerio, 204.5); idh3a (Xenopus tropicalis, 213.0); l(1)G0156 (Drosophila melanogaster, 199.5); idha-1 (Caenorhabditis elegans, 207.2); IDH-V (Arabidopsis thaliana, 219.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:187946-189061:- | gene-YIL094C_AKU4011 | rna-NM_001179442.1_AKU4011 | cds-NP_012172.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000164.1:50929-52044:- | gene-YIL094C_BG1 | rna-NM_001179442.1_BG1 | cds-NP_012172.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:192647-193762:- | gene-YIL094C_Bruggeman | rna-NM_001179442.1_Bruggeman | cds-NP_012172.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:184697-185812:- | gene-YIL094C_CAT1 | rna-NM_001179442.1_CAT1 | cds-NP_012172.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:188202-189317:- | gene-YIL094C_CBS1585 | rna-NM_001179442.1_CBS1585 | cds-NP_012172.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:179186-180301:- | gene-YIL094C_CBS436 | rna-NM_001179442.1_CBS436 | cds-NP_012172.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:185582-186697:- | gene-YIL094C_CBS6412 | rna-NM_001179442.1_CBS6412 | cds-NP_012172.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:179235-180350:- | gene-YIL094C_CBS6413 | rna-NM_001179442.1_CBS6413 | cds-NP_012172.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:178226-179341:- | gene-YIL094C_CENPK1137D | rna-NM_001179442.1_CENPK1137D | cds-NP_012172.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:173165-174280:- | gene-YIL094C_EthanolRed | rna-NM_001179442.1_EthanolRed | cds-NP_012172.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:189160-190275:- | gene-YIL094C_FaliES1 | rna-NM_001179442.1_FaliES1 | cds-NP_012172.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000025.1:38190-39305:+ | gene-YIL094C_JAY291 | rna-NM_001179442.1_JAY291 | cds-NP_012172.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:190372-191487:- | gene-YIL094C_MUCL30387 | rna-NM_001179442.1_MUCL30387 | cds-NP_012172.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:188163-189278:- | gene-YIL094C_MUCL30388 | rna-NM_001179442.1_MUCL30388 | cds-NP_012172.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:189049-190164:- | gene-YIL094C_MUCL39482 | rna-NM_001179442.1_MUCL39482 | cds-NP_012172.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:192297-193412:- | gene-YIL094C_MUCL42920 | rna-NM_001179442.1_MUCL42920 | cds-NP_012172.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:186517-187632:- | gene-YIL094C_NCIM3186 | rna-NM_001179442.1_NCIM3186 | cds-NP_012172.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:193093-194208:- | gene-YIL094C_NCYC1407 | rna-NM_001179442.1_NCYC1407 | cds-NP_012172.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:187654-188769:- | gene-YIL094C_PE2H3 | rna-NM_001179442.1_PE2H3 | cds-NP_012172.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:181605-182720:- | gene-YIL094C_PE2H4 | rna-NM_001179442.1_PE2H4 | cds-NP_012172.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:186517-187632:- | gene-YIL094C_S288C | rna-NM_001179442.1_S288C | cds-NP_012172.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000111.1:17655-18770:+ | gene-YIL094C_SA1 | rna-NM_001179442.1_SA1 | cds-NP_012172.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:187829-188944:- | gene-YIL094C_ThermosaccDry | rna-NM_001179442.1_ThermosaccDry | cds-NP_012172.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:185509-186624:- | gene-YIL094C_VR1 | rna-NM_001179442.1_VR1 | cds-NP_012172.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:162762-163877:- | gene-YIL094C_ZTW1 | rna-NM_001179442.1_ZTW1 | cds-NP_012172.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:186727-187842:- | gene-YIL094C_Sparadoxus | rna-NM_001179442.1_Sparadoxus | cds-NP_012172.1_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |