Gene name: LYS1
Reference locus (S288C): YIR034C
Gene biotype: protein_coding
Description: Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity; Belongs to the AlaDH/PNT family
Top 10 interactors (score): LYS9 (0.999); LYS4 (0.982); LYS12 (0.96); LYS2 (0.948); ARG5,6 (0.926); ARG1 (0.922); LYS20 (0.917); ARG4 (0.881); ARG7 (0.874); LYS21 (0.841); LEU2 (0.818); HIS4 (0.816); LYS14 (0.785); ARG8 (0.756); ARG3 (0.741); YHL018W (0.717); HIS5 (0.709); LYS5 (0.699); CAR1 (0.68); URA2 (0.674)
Homologues (species, bitscore): AASS (Homo sapiens, 65.5); Aass (Mus musculus, 72.8); aass (Danio rerio, 85.9); aass (Xenopus tropicalis, 80.1); LKR (Drosophila melanogaster, 74.7); aass-1 (Caenorhabditis elegans, 64.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:417844-418965:- | gene-YIR034C_AKU4011 | rna-NM_001179556.3_AKU4011 | cds-NP_012300.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000072.1:7870-8991:+ | gene-YIR034C_BG1 | rna-NM_001179556.3_BG1 | cds-NP_012300.3_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:424038-425159:- | gene-YIR034C_Bruggeman | rna-NM_001179556.3_Bruggeman | cds-NP_012300.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:408995-410116:- | gene-YIR034C_CAT1 | rna-NM_001179556.3_CAT1 | cds-NP_012300.3_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:418800-419921:- | gene-YIR034C_CBS1585 | rna-NM_001179556.3_CBS1585 | cds-NP_012300.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:410767-411888:- | gene-YIR034C_CBS436 | rna-NM_001179556.3_CBS436 | cds-NP_012300.3_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005327.1:117303-118424:- | gene-YIR034C_CBS6412 | rna-NM_001179556.3_CBS6412 | cds-NP_012300.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:409900-411021:- | gene-YIR034C_CBS6413 | rna-NM_001179556.3_CBS6413 | cds-NP_012300.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:411274-412395:- | gene-YIR034C_CENPK1137D | rna-NM_001179556.3_CENPK1137D | cds-NP_012300.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:400761-401882:- | gene-YIR034C_EthanolRed | rna-NM_001179556.3_EthanolRed | cds-NP_012300.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:420589-421710:- | gene-YIR034C_FaliES1 | rna-NM_001179556.3_FaliES1 | cds-NP_012300.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000039.1:12389-13510:+ | gene-YIR034C_JAY291 | rna-NM_001179556.3_JAY291 | cds-NP_012300.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:424791-425912:- | gene-YIR034C_MUCL30387 | rna-NM_001179556.3_MUCL30387 | cds-NP_012300.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:419409-420530:- | gene-YIR034C_MUCL30388 | rna-NM_001179556.3_MUCL30388 | cds-NP_012300.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:418947-420068:- | gene-YIR034C_MUCL39482 | rna-NM_001179556.3_MUCL39482 | cds-NP_012300.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:425253-426374:- | gene-YIR034C_MUCL42920 | rna-NM_001179556.3_MUCL42920 | cds-NP_012300.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:419615-420736:- | gene-YIR034C_NCIM3186 | rna-NM_001179556.3_NCIM3186 | cds-NP_012300.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:422707-423828:- | gene-YIR034C_NCYC1407 | rna-NM_001179556.3_NCYC1407 | cds-NP_012300.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:413626-414747:- | gene-YIR034C_PE2H3 | rna-NM_001179556.3_PE2H3 | cds-NP_012300.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:408332-409453:- | gene-YIR034C_PE2H4 | rna-NM_001179556.3_PE2H4 | cds-NP_012300.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:419615-420736:- | gene-YIR034C_S288C | rna-NM_001179556.3_S288C | cds-NP_012300.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000097.1:8114-9235:+ | gene-YIR034C_SA1 | rna-NM_001179556.3_SA1 | cds-NP_012300.3_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:417454-418575:- | gene-YIR034C_ThermosaccDry | rna-NM_001179556.3_ThermosaccDry | cds-NP_012300.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:414862-415983:- | gene-YIR034C_VR1 | rna-NM_001179556.3_VR1 | cds-NP_012300.3_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000020.1:26699-27820:- | gene-YIR034C_ZTW1 | rna-NM_001179556.3_ZTW1 | cds-NP_012300.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:415142-416263:- | gene-YIR034C_Sparadoxus | rna-NM_001179556.3_Sparadoxus | cds-NP_012300.3_Sparadoxus | 91.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |