Gene name: LTO1
Reference locus (S288C): YNL260C
Gene biotype: protein_coding
Description: Uncharacterized ORAOV1 family protein YNL260C; Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species; Belongs to the ORAOV1 family
Top 10 interactors (score): YAE1 (0.997); RLI1 (0.965); CFD1 (0.896); YJR012C (0.848); CIA2 (0.846); IBA57 (0.842); DRE2 (0.813); NBP35 (0.807); TTI2 (0.785); MET18 (0.772); TAH18 (0.766); YAH1 (0.762); NAR1 (0.748); ATM1 (0.701); NFU1 (0.665); SUA5 (0.655); GCV1 (0.652); LIP5 (0.613); NPA3 (0.601); ARC19 (0.571)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:150629-151117:- | gene-YNL260C_AKU4011 | rna-NM_001183098.2_AKU4011 | cds-NP_014139.2_AKU4011 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:54588-55076:- | gene-YNL260C_BG1 | rna-NM_001183098.2_BG1 | cds-NP_014139.2_BG1 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:160452-160940:- | gene-YNL260C_Bruggeman | rna-NM_001183098.2_Bruggeman | cds-NP_014139.2_Bruggeman | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:167748-168236:- | gene-YNL260C_CAT1 | rna-NM_001183098.2_CAT1 | cds-NP_014139.2_CAT1 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:151029-151517:- | gene-YNL260C_CBS1585 | rna-NM_001183098.2_CBS1585 | cds-NP_014139.2_CBS1585 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:146131-146619:- | gene-YNL260C_CBS436 | rna-NM_001183098.2_CBS436 | cds-NP_014139.2_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:147440-147928:- | gene-YNL260C_CBS6412 | rna-NM_001183098.2_CBS6412 | cds-NP_014139.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:147722-148210:- | gene-YNL260C_CBS6413 | rna-NM_001183098.2_CBS6413 | cds-NP_014139.2_CBS6413 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:150673-151161:- | gene-YNL260C_CENPK1137D | rna-NM_001183098.2_CENPK1137D | cds-NP_014139.2_CENPK1137D | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:148280-148768:- | gene-YNL260C_EthanolRed | rna-NM_001183098.2_EthanolRed | cds-NP_014139.2_EthanolRed | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:143015-143503:- | gene-YNL260C_FaliES1 | rna-NM_001183098.2_FaliES1 | cds-NP_014139.2_FaliES1 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000082.1:54186-54674:- | gene-YNL260C_JAY291 | rna-NM_001183098.2_JAY291 | cds-NP_014139.2_JAY291 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:156236-156724:- | gene-YNL260C_MUCL30387 | rna-NM_001183098.2_MUCL30387 | cds-NP_014139.2_MUCL30387 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:154821-155309:- | gene-YNL260C_MUCL30388 | rna-NM_001183098.2_MUCL30388 | cds-NP_014139.2_MUCL30388 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:148519-149007:- | gene-YNL260C_MUCL39482 | rna-NM_001183098.2_MUCL39482 | cds-NP_014139.2_MUCL39482 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:150787-151275:- | gene-YNL260C_MUCL42920 | rna-NM_001183098.2_MUCL42920 | cds-NP_014139.2_MUCL42920 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:156828-157316:- | gene-YNL260C_NCIM3186 | rna-NM_001183098.2_NCIM3186 | cds-NP_014139.2_NCIM3186 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:150624-151112:- | gene-YNL260C_NCYC1407 | rna-NM_001183098.2_NCYC1407 | cds-NP_014139.2_NCYC1407 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:147526-148014:- | gene-YNL260C_PE2H3 | rna-NM_001183098.2_PE2H3 | cds-NP_014139.2_PE2H3 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:146914-147402:- | gene-YNL260C_PE2H4 | rna-NM_001183098.2_PE2H4 | cds-NP_014139.2_PE2H4 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:156859-157347:- | gene-YNL260C_S288C | rna-NM_001183098.2_S288C | cds-NP_014139.2_S288C | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000040.1:94942-95430:+ | gene-YNL260C_SA1 | rna-NM_001183098.2_SA1 | cds-NP_014139.2_SA1 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:143871-144359:- | gene-YNL260C_ThermosaccDry | rna-NM_001183098.2_ThermosaccDry | cds-NP_014139.2_ThermosaccDry | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:162783-163271:- | gene-YNL260C_VR1 | rna-NM_001183098.2_VR1 | cds-NP_014139.2_VR1 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:54202-54690:- | gene-YNL260C_ZTW1 | rna-NM_001183098.2_ZTW1 | cds-NP_014139.2_ZTW1 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:154096-154584:- | gene-YNL260C_Sparadoxus | rna-NM_001183098.2_Sparadoxus | cds-NP_014139.2_Sparadoxus | 86.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |