Gene name: LST4
Reference locus (S288C): YKL176C
Gene biotype: protein_coding
Description: Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface
Top 10 interactors (score): LST7 (0.997); SEC13 (0.933); BFA1 (0.9); BUB2 (0.9); LST8 (0.858); GAP1 (0.853); GTR2 (0.847); SEA4 (0.842); MTC5 (0.809); BUL1 (0.795); GTR1 (0.782); ROG1 (0.78); NAT5 (0.78); NPR1 (0.78); BUL2 (0.78); PIB2 (0.767); MEH1 (0.75); EGO2 (0.748); SLM4 (0.747); RTC1 (0.744)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:102355-104841:- | gene-YKL176C_AKU4011 | rna-NM_001179742.1_AKU4011 | cds-NP_012745.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:78912-81398:- | gene-YKL176C_BG1 | rna-NM_001179742.1_BG1 | cds-NP_012745.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:119745-122231:- | gene-YKL176C_Bruggeman | rna-NM_001179742.1_Bruggeman | cds-NP_012745.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:114707-117193:- | gene-YKL176C_CAT1 | rna-NM_001179742.1_CAT1 | cds-NP_012745.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:114339-116825:- | gene-YKL176C_CBS1585 | rna-NM_001179742.1_CBS1585 | cds-NP_012745.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:113103-115589:- | gene-YKL176C_CBS436 | rna-NM_001179742.1_CBS436 | cds-NP_012745.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:99929-102415:- | gene-YKL176C_CBS6412 | rna-NM_001179742.1_CBS6412 | cds-NP_012745.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:115055-117541:- | gene-YKL176C_CBS6413 | rna-NM_001179742.1_CBS6413 | cds-NP_012745.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:115326-117812:- | gene-YKL176C_CENPK1137D | rna-NM_001179742.1_CENPK1137D | cds-NP_012745.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:113241-115727:- | gene-YKL176C_EthanolRed | rna-NM_001179742.1_EthanolRed | cds-NP_012745.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:113942-116428:- | gene-YKL176C_FaliES1 | rna-NM_001179742.1_FaliES1 | cds-NP_012745.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:112926-115412:- | gene-YKL176C_JAY291 | rna-NM_001179742.1_JAY291 | cds-NP_012745.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:122045-124531:- | gene-YKL176C_MUCL30387 | rna-NM_001179742.1_MUCL30387 | cds-NP_012745.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:116389-118875:- | gene-YKL176C_MUCL30388 | rna-NM_001179742.1_MUCL30388 | cds-NP_012745.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:114394-116880:- | gene-YKL176C_MUCL39482 | rna-NM_001179742.1_MUCL39482 | cds-NP_012745.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:118729-121215:- | gene-YKL176C_MUCL42920 | rna-NM_001179742.1_MUCL42920 | cds-NP_012745.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:115489-117975:- | gene-YKL176C_NCIM3186 | rna-NM_001179742.1_NCIM3186 | cds-NP_012745.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:114418-116904:- | gene-YKL176C_NCYC1407 | rna-NM_001179742.1_NCYC1407 | cds-NP_012745.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:121478-123964:- | gene-YKL176C_PE2H3 | rna-NM_001179742.1_PE2H3 | cds-NP_012745.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:117772-120258:- | gene-YKL176C_PE2H4 | rna-NM_001179742.1_PE2H4 | cds-NP_012745.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:115500-117986:- | gene-YKL176C_S288C | rna-NM_001179742.1_S288C | cds-NP_012745.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:31708-34194:- | gene-YKL176C_SA1 | rna-NM_001179742.1_SA1 | cds-NP_012745.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:114642-117128:- | gene-YKL176C_ThermosaccDry | rna-NM_001179742.1_ThermosaccDry | cds-NP_012745.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:113183-115669:- | gene-YKL176C_VR1 | rna-NM_001179742.1_VR1 | cds-NP_012745.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:113052-115538:- | gene-YKL176C_ZTW1 | rna-NM_001179742.1_ZTW1 | cds-NP_012745.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:127577-130063:- | gene-YKL176C_Sparadoxus | rna-NM_001179742.1_Sparadoxus | cds-NP_012745.1_Sparadoxus | 89.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |