Gene name: LSM1
Reference locus (S288C): YJL124C
Gene biotype: protein_coding
Description: Sm-like protein LSm1; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress
Top 10 interactors (score): DCP1 (0.999); LSM8 (0.999); LSM2 (0.999); LSM5 (0.999); LSM6 (0.999); DHH1 (0.999); LSM4 (0.999); EDC3 (0.999); LSM3 (0.999); PAT1 (0.999); LSM7 (0.999); XRN1 (0.999); DCP2 (0.999); SCD6 (0.988); PAB1 (0.974); NAM7 (0.973); SMD1 (0.966); CDC33 (0.958); CCR4 (0.953); SMD2 (0.951)
Homologues (species, bitscore): LSM1 (Homo sapiens, 97.4); Lsm1 (Mus musculus, 98.2); lsm1 (Danio rerio, 100.1); lsm1 (Xenopus tropicalis, 92.0); LSm1 (Drosophila melanogaster, 97.4); lsm-1 (Caenorhabditis elegans, 74.7); LSM1A (Arabidopsis thaliana, 85.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:175446-175964:- | gene-YJL124C_AKU4011 | rna-NM_001181557.1_AKU4011 | cds-NP_012411.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:437779-438297:+ | gene-YJL124C_BG1 | rna-NM_001181557.1_BG1 | cds-NP_012411.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:187485-188003:- | gene-YJL124C_Bruggeman | rna-NM_001181557.1_Bruggeman | cds-NP_012411.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:191295-191813:- | gene-YJL124C_CAT1 | rna-NM_001181557.1_CAT1 | cds-NP_012411.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:181080-181598:- | gene-YJL124C_CBS1585 | rna-NM_001181557.1_CBS1585 | cds-NP_012411.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:205810-206328:- | gene-YJL124C_CBS436 | rna-NM_001181557.1_CBS436 | cds-NP_012411.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:177097-177615:- | gene-YJL124C_CBS6412 | rna-NM_001181557.1_CBS6412 | cds-NP_012411.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:178555-179073:- | gene-YJL124C_CBS6413 | rna-NM_001181557.1_CBS6413 | cds-NP_012411.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:169596-170114:- | gene-YJL124C_CENPK1137D | rna-NM_001181557.1_CENPK1137D | cds-NP_012411.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:179415-179933:- | gene-YJL124C_EthanolRed | rna-NM_001181557.1_EthanolRed | cds-NP_012411.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:185067-185585:- | gene-YJL124C_FaliES1 | rna-NM_001181557.1_FaliES1 | cds-NP_012411.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000099.1:66232-66750:- | gene-YJL124C_JAY291 | rna-NM_001181557.1_JAY291 | cds-NP_012411.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:189753-190271:- | gene-YJL124C_MUCL30387 | rna-NM_001181557.1_MUCL30387 | cds-NP_012411.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:185831-186349:- | gene-YJL124C_MUCL30388 | rna-NM_001181557.1_MUCL30388 | cds-NP_012411.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:180026-180544:- | gene-YJL124C_MUCL39482 | rna-NM_001181557.1_MUCL39482 | cds-NP_012411.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:185819-186337:- | gene-YJL124C_MUCL42920 | rna-NM_001181557.1_MUCL42920 | cds-NP_012411.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:187105-187623:- | gene-YJL124C_NCIM3186 | rna-NM_001181557.1_NCIM3186 | cds-NP_012411.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:178433-178951:- | gene-YJL124C_NCYC1407 | rna-NM_001181557.1_NCYC1407 | cds-NP_012411.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:191212-191730:- | gene-YJL124C_PE2H3 | rna-NM_001181557.1_PE2H3 | cds-NP_012411.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:190856-191374:- | gene-YJL124C_PE2H4 | rna-NM_001181557.1_PE2H4 | cds-NP_012411.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:187126-187644:- | gene-YJL124C_S288C | rna-NM_001181557.1_S288C | cds-NP_012411.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000085.1:11526-12044:+ | gene-YJL124C_SA1 | rna-NM_001181557.1_SA1 | cds-NP_012411.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:178258-178776:- | gene-YJL124C_ThermosaccDry | rna-NM_001181557.1_ThermosaccDry | cds-NP_012411.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:185329-185847:- | gene-YJL124C_VR1 | rna-NM_001181557.1_VR1 | cds-NP_012411.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:165537-166055:- | gene-YJL124C_ZTW1 | rna-NM_001181557.1_ZTW1 | cds-NP_012411.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:190733-191251:- | gene-YJL124C_Sparadoxus | rna-NM_001181557.1_Sparadoxus | cds-NP_012411.1_Sparadoxus | 93.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |