Gene name: LSB1
Reference locus (S288C): YGR136W
Gene biotype: protein_coding
Description: LAS seventeen-binding protein 1; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication
Top 10 interactors (score): PIN3 (0.999); LAS17 (0.989); BBC1 (0.928); RSP5 (0.921); VRP1 (0.909); BZZ1 (0.889); CDC25 (0.869); LTE1 (0.863); BUD5 (0.863); YCL068C (0.863); YGR137W (0.861); ABP1 (0.851); PAN1 (0.84); BOI2 (0.838); MYO3 (0.828); SUP35 (0.797); ACT1 (0.759); PLC1 (0.758); SLA1 (0.749); ARP2 (0.748)
Homologues (species, bitscore): SH3D19 (Homo sapiens, 70.9); Sh3d19 (Mus musculus, 69.7); grb2a (Danio rerio, 68.9); sh3d19 (Xenopus tropicalis, 65.9); l(3)05822 (Drosophila melanogaster, 61.6); sem-5 (Caenorhabditis elegans, 66.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:741406-742131:+ | gene-YGR136W_AKU4011 | rna-NM_001181265.1_AKU4011 | cds-NP_011652.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:20178-20903:+ | gene-YGR136W_BG1 | rna-NM_001181265.1_BG1 | cds-NP_011652.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:744202-744927:+ | gene-YGR136W_Bruggeman | rna-NM_001181265.1_Bruggeman | cds-NP_011652.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:742950-743675:+ | gene-YGR136W_CAT1 | rna-NM_001181265.1_CAT1 | cds-NP_011652.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:742389-743114:+ | gene-YGR136W_CBS1585 | rna-NM_001181265.1_CBS1585 | cds-NP_011652.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:745779-746504:+ | gene-YGR136W_CBS436 | rna-NM_001181265.1_CBS436 | cds-NP_011652.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:734065-734789:+ | gene-YGR136W_CBS6412 | rna-NM_001181265.1_CBS6412 | cds-NP_011652.1_CBS6412 | 99.7 | 99.8 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:738998-739723:+ | gene-YGR136W_CBS6413 | rna-NM_001181265.1_CBS6413 | cds-NP_011652.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:762140-762865:+ | gene-YGR136W_CENPK1137D | rna-NM_001181265.1_CENPK1137D | cds-NP_011652.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:728430-729155:+ | gene-YGR136W_EthanolRed | rna-NM_001181265.1_EthanolRed | cds-NP_011652.1_EthanolRed | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:732291-733016:+ | gene-YGR136W_FaliES1 | rna-NM_001181265.1_FaliES1 | cds-NP_011652.1_FaliES1 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000305.1:829-1554:- | gene-YGR136W_JAY291 | rna-NM_001181265.1_JAY291 | cds-NP_011652.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:851342-852067:+ | gene-YGR136W_MUCL30387 | rna-NM_001181265.1_MUCL30387 | cds-NP_011652.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:744217-744942:+ | gene-YGR136W_MUCL30388 | rna-NM_001181265.1_MUCL30388 | cds-NP_011652.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:738115-738840:+ | gene-YGR136W_MUCL39482 | rna-NM_001181265.1_MUCL39482 | cds-NP_011652.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:748213-748938:+ | gene-YGR136W_MUCL42920 | rna-NM_001181265.1_MUCL42920 | cds-NP_011652.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:762428-763153:+ | gene-YGR136W_NCIM3186 | rna-NM_001181265.1_NCIM3186 | cds-NP_011652.1_NCIM3186 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:732816-733541:+ | gene-YGR136W_NCYC1407 | rna-NM_001181265.1_NCYC1407 | cds-NP_011652.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:752669-753394:+ | gene-YGR136W_PE2H3 | rna-NM_001181265.1_PE2H3 | cds-NP_011652.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:757779-758504:+ | gene-YGR136W_PE2H4 | rna-NM_001181265.1_PE2H4 | cds-NP_011652.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:762428-763153:+ | gene-YGR136W_S288C | rna-NM_001181265.1_S288C | cds-NP_011652.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000015.1:183564-184289:+ | gene-YGR136W_SA1 | rna-NM_001181265.1_SA1 | cds-NP_011652.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:752914-753639:+ | gene-YGR136W_ThermosaccDry | rna-NM_001181265.1_ThermosaccDry | cds-NP_011652.1_ThermosaccDry | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:856416-857141:+ | gene-YGR136W_VR1 | rna-NM_001181265.1_VR1 | cds-NP_011652.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:55060-55785:+ | gene-YGR136W_ZTW1 | rna-NM_001181265.1_ZTW1 | cds-NP_011652.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:742719-743444:+ | gene-YGR136W_Sparadoxus | rna-NM_001181265.1_Sparadoxus | cds-NP_011652.1_Sparadoxus | 89.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |