Gene name: LPD1
Reference locus (S288C): YFL018C
Gene biotype: protein_coding
Description: Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication
Top 10 interactors (score): KGD2 (0.999); PDA1 (0.999); PDX1 (0.999); LAT1 (0.999); PDB1 (0.999); KGD1 (0.999); GCV3 (0.997); GCV1 (0.997); LSC2 (0.997); GCV2 (0.996); IDH1 (0.99); LSC1 (0.988); IDH2 (0.984); YMR31 (0.982); AIM22 (0.975); SHM2 (0.971); FUM1 (0.968); MDH1 (0.96); SHM1 (0.955); AGX1 (0.953)
Homologues (species, bitscore): DLD (Homo sapiens, 554.7); Dld (Mus musculus, 550.4); dldh (Danio rerio, 563.5); dld (Xenopus tropicalis, 551.2); CG7430 (Drosophila melanogaster, 560.8); dld-1 (Caenorhabditis elegans, 560.8); mtLPD1 (Arabidopsis thaliana, 550.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:98074-99573:- | gene-YFL018C_AKU4011 | rna-NM_001179948.1_AKU4011 | cds-NP_116635.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000203.1:7384-8883:+ | gene-YFL018C_BG1 | rna-NM_001179948.1_BG1 | cds-NP_116635.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:97424-98923:- | gene-YFL018C_Bruggeman | rna-NM_001179948.1_Bruggeman | cds-NP_116635.1_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:103013-104512:- | gene-YFL018C_CAT1 | rna-NM_001179948.1_CAT1 | cds-NP_116635.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:98893-100392:- | gene-YFL018C_CBS1585 | rna-NM_001179948.1_CBS1585 | cds-NP_116635.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:73070-74569:- | gene-YFL018C_CBS436 | rna-NM_001179948.1_CBS436 | cds-NP_116635.1_CBS436 | 98.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:98625-100124:- | gene-YFL018C_CBS6412 | rna-NM_001179948.1_CBS6412 | cds-NP_116635.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:101160-102659:- | gene-YFL018C_CBS6413 | rna-NM_001179948.1_CBS6413 | cds-NP_116635.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:97957-99456:- | gene-YFL018C_CENPK1137D | rna-NM_001179948.1_CENPK1137D | cds-NP_116635.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:97060-98559:- | gene-YFL018C_EthanolRed | rna-NM_001179948.1_EthanolRed | cds-NP_116635.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:98700-100199:- | gene-YFL018C_FaliES1 | rna-NM_001179948.1_FaliES1 | cds-NP_116635.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000449.1:177-1676:- | gene-YFL018C_JAY291 | rna-NM_001179948.1_JAY291 | cds-NP_116635.1_JAY291 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:99041-100540:- | gene-YFL018C_MUCL30387 | rna-NM_001179948.1_MUCL30387 | cds-NP_116635.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:96972-98471:- | gene-YFL018C_MUCL30388 | rna-NM_001179948.1_MUCL30388 | cds-NP_116635.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:97272-98771:- | gene-YFL018C_MUCL39482 | rna-NM_001179948.1_MUCL39482 | cds-NP_116635.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:96614-98113:- | gene-YFL018C_MUCL42920 | rna-NM_001179948.1_MUCL42920 | cds-NP_116635.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:101627-103126:- | gene-YFL018C_NCIM3186 | rna-NM_001179948.1_NCIM3186 | cds-NP_116635.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:98362-99861:- | gene-YFL018C_NCYC1407 | rna-NM_001179948.1_NCYC1407 | cds-NP_116635.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:118208-119707:- | gene-YFL018C_PE2H3 | rna-NM_001179948.1_PE2H3 | cds-NP_116635.1_PE2H3 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:117756-119255:- | gene-YFL018C_PE2H4 | rna-NM_001179948.1_PE2H4 | cds-NP_116635.1_PE2H4 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:101628-103127:- | gene-YFL018C_S288C | rna-NM_001179948.1_S288C | cds-NP_116635.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000105.1:14348-15847:- | gene-YFL018C_SA1 | rna-NM_001179948.1_SA1 | cds-NP_116635.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:97882-99381:- | gene-YFL018C_ThermosaccDry | rna-NM_001179948.1_ThermosaccDry | cds-NP_116635.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:106901-108400:- | gene-YFL018C_VR1 | rna-NM_001179948.1_VR1 | cds-NP_116635.1_VR1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:28321-29820:- | gene-YFL018C_ZTW1 | rna-NM_001179948.1_ZTW1 | cds-NP_116635.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:122518-124017:- | gene-YFL018C_Sparadoxus | rna-NM_001179948.1_Sparadoxus | cds-NP_116635.1_Sparadoxus | 91.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |