Gene name: LOS1
Reference locus (S288C): YKL205W
Gene biotype: protein_coding
Description: Exportin-T; Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction
Top 10 interactors (score): GSP1 (0.998); MSN5 (0.994); MTR10 (0.993); CRM1 (0.993); CSE1 (0.974); GSP2 (0.972); SOL1 (0.954); LHP1 (0.953); CEX1 (0.941); MEX67 (0.94); NUP2 (0.94); KAP123 (0.935); ILS1 (0.924); RNA1 (0.921); MES1 (0.921); SOL2 (0.92); KAP122 (0.916); ARC1 (0.913); NTF2 (0.911); SOL3 (0.911)
Homologues (species, bitscore): XPOT (Homo sapiens, 160.2); Xpot (Mus musculus, 164.9); xpot (Danio rerio, 152.5); xpot (Xenopus tropicalis, 149.4); xpo-3 (Caenorhabditis elegans, 92.0); PSD (Arabidopsis thaliana, 140.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:36365-39667:+ | gene-YKL205W_AKU4011 | rna-NM_001179770.1_AKU4011 | cds-NP_012717.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:13449-16751:+ | gene-YKL205W_BG1 | rna-NM_001179770.1_BG1 | cds-NP_012717.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:54037-57339:+ | gene-YKL205W_Bruggeman | rna-NM_001179770.1_Bruggeman | cds-NP_012717.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:49228-52530:+ | gene-YKL205W_CAT1 | rna-NM_001179770.1_CAT1 | cds-NP_012717.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:48377-51679:+ | gene-YKL205W_CBS1585 | rna-NM_001179770.1_CBS1585 | cds-NP_012717.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:47578-50880:+ | gene-YKL205W_CBS436 | rna-NM_001179770.1_CBS436 | cds-NP_012717.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:33634-36936:+ | gene-YKL205W_CBS6412 | rna-NM_001179770.1_CBS6412 | cds-NP_012717.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:49014-52316:+ | gene-YKL205W_CBS6413 | rna-NM_001179770.1_CBS6413 | cds-NP_012717.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:49833-53135:+ | gene-YKL205W_CENPK1137D | rna-NM_001179770.1_CENPK1137D | cds-NP_012717.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:47848-51150:+ | gene-YKL205W_EthanolRed | rna-NM_001179770.1_EthanolRed | cds-NP_012717.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:47907-51209:+ | gene-YKL205W_FaliES1 | rna-NM_001179770.1_FaliES1 | cds-NP_012717.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:47521-50823:+ | gene-YKL205W_JAY291 | rna-NM_001179770.1_JAY291 | cds-NP_012717.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:56572-59874:+ | gene-YKL205W_MUCL30387 | rna-NM_001179770.1_MUCL30387 | cds-NP_012717.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:50660-53962:+ | gene-YKL205W_MUCL30388 | rna-NM_001179770.1_MUCL30388 | cds-NP_012717.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:48434-51736:+ | gene-YKL205W_MUCL39482 | rna-NM_001179770.1_MUCL39482 | cds-NP_012717.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:51728-55030:+ | gene-YKL205W_MUCL42920 | rna-NM_001179770.1_MUCL42920 | cds-NP_012717.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:50040-53342:+ | gene-YKL205W_NCIM3186 | rna-NM_001179770.1_NCIM3186 | cds-NP_012717.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:48458-51760:+ | gene-YKL205W_NCYC1407 | rna-NM_001179770.1_NCYC1407 | cds-NP_012717.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:56156-59458:+ | gene-YKL205W_PE2H3 | rna-NM_001179770.1_PE2H3 | cds-NP_012717.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:52354-55656:+ | gene-YKL205W_PE2H4 | rna-NM_001179770.1_PE2H4 | cds-NP_012717.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:50051-53353:+ | gene-YKL205W_S288C | rna-NM_001179770.1_S288C | cds-NP_012717.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000092.1:14520-17822:- | gene-YKL205W_SA1 | rna-NM_001179770.1_SA1 | cds-NP_012717.1_SA1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:48655-51957:+ | gene-YKL205W_ThermosaccDry | rna-NM_001179770.1_ThermosaccDry | cds-NP_012717.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:47760-51062:+ | gene-YKL205W_VR1 | rna-NM_001179770.1_VR1 | cds-NP_012717.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:47568-50870:+ | gene-YKL205W_ZTW1 | rna-NM_001179770.1_ZTW1 | cds-NP_012717.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:56310-59615:+ | gene-YKL205W_Sparadoxus | rna-NM_001179770.1_Sparadoxus | cds-NP_012717.1_Sparadoxus | 92.8 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |