Gene name: LEU9
Reference locus (S288C): YOR108W
Gene biotype: protein_coding
Description: Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily
Top 10 interactors (score): LEU4 (0.999); ILV3 (0.996); LEU1 (0.995); BAT2 (0.981); ILV2 (0.971); BAT1 (0.948); ACS2 (0.929); ERG10 (0.928); ILV6 (0.922); LYS21 (0.921); ACS1 (0.921); LYS20 (0.921); LAT1 (0.913); ACC1 (0.913); HFA1 (0.913); DAL7 (0.907); MLS1 (0.905); ACH1 (0.901); ARG1 (0.898); MAE1 (0.884)
Homologues (species, bitscore): MAML-4 (Arabidopsis thaliana, 125.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:507080-508894:+ | gene-YOR108W_AKU4011 | rna-NM_001183527.1_AKU4011 | cds-NP_014751.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000171.1:70167-71981:- | gene-YOR108W_BG1 | rna-NM_001183527.1_BG1 | cds-NP_014751.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:510669-512483:+ | gene-YOR108W_Bruggeman | rna-NM_001183527.1_Bruggeman | cds-NP_014751.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:510658-512472:+ | gene-YOR108W_CAT1 | rna-NM_001183527.1_CAT1 | cds-NP_014751.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:502653-504433:+ | gene-YOR108W_CBS1585 | rna-NM_001183527.1_CBS1585 | cds-NP_014751.1_CBS1585 | 97.7 | 98.1 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:507394-509208:+ | gene-YOR108W_CBS436 | rna-NM_001183527.1_CBS436 | cds-NP_014751.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:501131-502945:+ | gene-YOR108W_CBS6412 | rna-NM_001183527.1_CBS6412 | cds-NP_014751.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:508428-510242:+ | gene-YOR108W_CBS6413 | rna-NM_001183527.1_CBS6413 | cds-NP_014751.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:523107-524921:+ | gene-YOR108W_CENPK1137D | rna-NM_001183527.1_CENPK1137D | cds-NP_014751.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:503631-505445:+ | gene-YOR108W_EthanolRed | rna-NM_001183527.1_EthanolRed | cds-NP_014751.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:507133-508947:+ | gene-YOR108W_FaliES1 | rna-NM_001183527.1_FaliES1 | cds-NP_014751.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000063.1:50296-52110:- | gene-YOR108W_JAY291 | rna-NM_001183527.1_JAY291 | cds-NP_014751.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:515227-517041:+ | gene-YOR108W_MUCL30387 | rna-NM_001183527.1_MUCL30387 | cds-NP_014751.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:520405-522219:+ | gene-YOR108W_MUCL30388 | rna-NM_001183527.1_MUCL30388 | cds-NP_014751.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:510018-511832:+ | gene-YOR108W_MUCL39482 | rna-NM_001183527.1_MUCL39482 | cds-NP_014751.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:526118-527932:+ | gene-YOR108W_MUCL42920 | rna-NM_001183527.1_MUCL42920 | cds-NP_014751.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:522916-524730:+ | gene-YOR108W_NCIM3186 | rna-NM_001183527.1_NCIM3186 | cds-NP_014751.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:516488-518302:+ | gene-YOR108W_NCYC1407 | rna-NM_001183527.1_NCYC1407 | cds-NP_014751.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:515486-517300:+ | gene-YOR108W_PE2H3 | rna-NM_001183527.1_PE2H3 | cds-NP_014751.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:525863-527677:+ | gene-YOR108W_PE2H4 | rna-NM_001183527.1_PE2H4 | cds-NP_014751.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:523027-524841:+ | gene-YOR108W_S288C | rna-NM_001183527.1_S288C | cds-NP_014751.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000034.1:52551-54365:+ | gene-YOR108W_SA1 | rna-NM_001183527.1_SA1 | cds-NP_014751.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:506293-508107:+ | gene-YOR108W_ThermosaccDry | rna-NM_001183527.1_ThermosaccDry | cds-NP_014751.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:508413-510227:+ | gene-YOR108W_VR1 | rna-NM_001183527.1_VR1 | cds-NP_014751.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:240281-242095:+ | gene-YOR108W_ZTW1 | rna-NM_001183527.1_ZTW1 | cds-NP_014751.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:512305-514119:+ | gene-YOR108W_Sparadoxus | rna-NM_001183527.1_Sparadoxus | cds-NP_014751.1_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |